Medical Devices and Adolescents

Samuels‐Reid, Joy H.; Cope, Judith U.

doi:10.1001/jamapediatrics.2016.1351

Cited by 6 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When children receive implants, they typically need additional, invasive surgeries as they grow to replace their original implant. [ 264 ] While cuff electrodes that are made of elastomers are stretchable and can expand, this deformation is elastic in nature [ 265 ] and the surface array applies a compressive force on the underlying tissue and can damage the native architecture. One of the first demonstrations of morphing electronics, or implants that are able to grow with the underlying tissue rather than impede its mechanical transformation, was in peripheral nerve.…”

Section: Surface Electrode Arrays For the Central And Peripheral Nerv...mentioning

confidence: 99%

Materials for Implantable Surface Electrode Arrays: Current Status and Future Directions

Tringides

Mooney

2022

Advanced Materials

View full text Add to dashboard Cite

with the outermost layer of biological tissues, often spanning a significant surface area. Devices typically have multiple electrodes that aim to monitor and modulate cells and tissues in a minimally invasive manner, using biomaterials designed to evoke minimal inflammatory responses. Applications of Surface Electrode Arrays RecordingBecause surface electrode arrays can record a "snapshot" of the electrical activity at distinct locations, these arrays are useful to monitor the function of a tissue. Though the recordings are typically local field potentials, with electrodes that are small enough to modulate as little of a location as possible while still maintaining a sufficiently high conductivity, single units from individual cells have been reported. Clinically, these recordings are used to map the epicardial surface to identify instances, and potentially mechanisms, of chronic atrial fibrillation, [1] dysfunction of ventricular tachycardia caused by congenital defects, [2] and other abnormal conduction conditions in the cardiac system. Clinical electrocorticogram (ECoG) is used to identify similar functional changes on the cortical surface of the brain, most commonly to identify epileptic focal center(s), or detect seizure activity. [3][4][5][6][7] Other functional uses of ECoG include intraoperative monitoring during tumor resection. [8] A surgeon can ask a patient to perform an activity such as a speech and then identify and avoid the active cortical regions during surgery, to avoid major disruptions to the patient quality of life. StimulationInstead of passively monitoring electrical activity, multielectrode surface arrays can provide electrical current to the underlying tissue and induce a desired excitatory or inhibitory response. The applications for stimulating surface electrode arrays are often therapeutic and include implantable pacemakers, which restore a normal cardiac rhythm by providing external and overriding cues to the cardiomyocytes responsible for establishing a sinus rhythm. [9] Pulses delivered to specific regions of the spinal cord are used to manage chronic pain, [10][11][12] and more recently as a therapy to promote neuronal plasticity in Surface electrode arrays are mainly fabricated from rigid or elastic materials, and precisely manipulated ductile metal films, which offer limited stretchability. However, the living tissues to which they are applied are nonlinear viscoelastic materials, which can undergo significant mechanical deformation in dynamic biological environments. Further, the same arrays and compositions are often repurposed for vastly different tissues rather than optimizing the materials and mechanical properties of the implant for the target application. By first characterizing the desired biological environment, and then designing a technology for a particular organ, surface electrode arrays may be more conformable, and offer better interfaces to tissues while causing less damage. Here, the various materials used in each component of a surface electrode array are first r...

show abstract

Section: Surface Electrode Arrays For the Central And Peripheral Nerv...mentioning

confidence: 99%

Materials for Implantable Surface Electrode Arrays: Current Status and Future Directions

Tringides

Mooney

2022

Advanced Materials

View full text Add to dashboard Cite

show abstract

“…Young children implanted with devices like VNS suffer from severe tissue constraints and functional damage as they grow. [ 88,89 ] Liu et al. developed a system of growth‐adaptive soft electronics named “morphing electronics” or MorphE [ 90 ] (Figure 5D).…”

Section: Peripheral Nerve Electronic Interfacementioning

confidence: 99%

Conjugated Polymer for Implantable Electronics toward Clinical Application

Liu

Feig

Bao

2021

Adv Healthcare Materials

View full text Add to dashboard Cite

Owing to their excellent mechanical flexibility, mixed‐conducting electrical property, and extraordinary chemical turnability, conjugated polymers have been demonstrated to be an ideal bioelectronic interface to deliver therapeutic effect in many different chronic diseases. This review article summarizes the latest advances in implantable electronics using conjugated polymers as electroactive materials and identifies remaining challenges and opportunities for developing electronic medicine. Examples of conjugated polymer‐based bioelectronic devices are selectively reviewed in human clinical studies or animal studies with the potential for clinical adoption. The unique properties of conjugated polymers are highlighted and exemplified as potential solutions to address the specific challenges in electronic medicine.

show abstract