Medical Evacuation of First Trimester (Twelve Weeks Gestation) Incomplete Abortion and Missed Abortion

Abstract

The objective was to assess the feasibility of nonsurgical evacuation of first trimester pregnancy wastage. A randomized control trial involving three groups: (1) dilatation and curettage (D&C) only, (2) intramuscular prostaglandin methyl-F2a, 500 ixg in a single injection (PGmF2(ï, 500 pug IM), (3) oral Trilostane, 120 mg every 6 hours on four occasions, together with PGmF2o, 500 \xg IM administered with the third trilostane dosage. Sixteen patients were referred to the Coombe Hospital and diagnosed ultrasonographically as having an incomplete miscarriage or missed abortion of < 12 weeks gestation. Treatment failures were subjected to D&C. The main outcome measures included the number of complete evacuations diagnosed ultrasonographically, analgesic requirements, side effects, and symptoms at 6 weeks after treatment. Using a reduction in uterine cavity surface area to < 6 cm2 as success following treatment, complete evacuation occurred in 100% of women treated with Trilostane and prostaglandin, 50% of women treated with prostaglandin only, and 40% of women treated by D&C only. The combination of Trilostane and prostaglandin is very effective in evacuating first trimester incomplete miscarriage or missed abortion. However, further dosage refinements are necessary to minimize prostaglandin side effects. (J GYNE-COLSURG 8:159, 1992) Address reprint requests to: Eftis Paraskevaides Lecturer for the RCSI Coombe Lying In Hospital Dublin 8Ireland

Medical treatments for incomplete miscarriage (less than 24 weeks)

“…We have tried to contact the authors to ask if they could provide their data spilt by women with ICMand women with IUFD. To date we have had no response but we are still trying to contact the authors using a different email addressNiromanesh 2005Participants were women with an intrauterine fetal death.Nor Azlin 2006Participants were women having a termination of pregnancy, including women with an intrauterine fetal deathNuthalapaty 2005Participants were women having a termination of pregnancy, including women with an intrauterine fetal deathNuutila 1997Participants were women having a termination of pregnancy, including women with an intrauterine fetal deathOwen 1999Participants were women with indication for termination of pregnancyParaskevaides 1992Included both women with incomplete miscarriage and women with intrauterine fetal death. We were unable to contact the authors to request split dataPerry 1999Participants were women with indication for termination of pregnancyPiotrowski 1979Participants were women with an intrauterine fetal death.Pongsatha 2004Participants were women with indication for termination of pregnancyRamsey 2004Participants were women with indication for termination of pregnancyRita 2006Participants were women with an intrauterine fetal death.Rivero-Lopez 1998Participants were women with an intrauterine fetal death.Rosenberg 2006Participants were women with an intrauterine fetal death.Roy 2003Participants were women with indication for termination of pregnancyRuangchainikhom 2006Participants were women with in...…”