Medical gallery of Blausen Medical 2014

doi:10.15347/wjm/2014.010

Cited by 118 publications

(19 citation statements)

References 32 publications

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“…In normal , interleukin-1β, transforming growth factor beta (TGFβ), and chemokine CCL2 are secreted in high concentrations creating a neuroinflammatory milieu. Cells adapted from Blausen Medical Gallery [58] brains, these radial glial-like astrocytes send their radial processes through the granule cell layer providing a scaffold for the normal growth and integration of the granule cell apical dendrites [79][80][81][82]. Following pilocarpine, neonatal hypoxia, or TBI, these astrocytes were shown to be hypertrophied.…”

Section: Astrocytes and Pte: Support Cell Inflammatory Mediator Or mentioning

confidence: 99%

Neuroinflammatory mechanisms of post-traumatic epilepsy

Mukherjee

Arisi

Mims

et al. 2020

J Neuroinflammation

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Background: Traumatic brain injury (TBI) occurs in as many as 64-74 million people worldwide each year and often results in one or more post-traumatic syndromes, including depression, cognitive, emotional, and behavioral deficits. TBI can also increase seizure susceptibility, as well as increase the incidence of epilepsy, a phenomenon known as post-traumatic epilepsy (PTE). Injury type and severity appear to partially predict PTE susceptibility. However, a complete mechanistic understanding of risk factors for PTE is incomplete. Main body: From the earliest days of modern neuroscience, to the present day, accumulating evidence supports a significant role for neuroinflammation in the post-traumatic epileptogenic progression. Notably, substantial evidence indicates a role for astrocytes, microglia, chemokines, and cytokines in PTE progression. Although each of these mechanistic components is discussed in separate sections, it is highly likely that it is the totality of cellular and neuroinflammatory interactions that ultimately contribute to the epileptogenic progression following TBI. Conclusion: This comprehensive review focuses on the neuroinflammatory milieu and explores putative mechanisms involved in the epileptogenic progression from TBI to increased seizure-susceptibility and the development of PTE.

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Section: Astrocytes and Pte: Support Cell Inflammatory Mediator Or mentioning

confidence: 99%

Neuroinflammatory mechanisms of post-traumatic epilepsy

Mukherjee

Arisi

Mims

et al. 2020

J Neuroinflammation

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“…It is well known that the endothelium is equipped with machinery that perceives mechanical forces and converts them in biochemical signals (Chatterjee and Fisher, 2014). Channels, glycocalyx, integrins, cell receptors, and cytoskeleton, among others, are involved in mechanosensing and mechanosignaling to intracellular signaling pathways (Harding and Ebong, 2014;Yamashiro and Yanagisawa, 2020). The cytoskeleton is a dynamic structure fundamental not only for the maintenance of the shape and the inner organization of the cell but also for the correct function of different organelles and the transport of molecules within the cell (Martino et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Cytoskeletal Remodeling Mimics Endothelial Response to Microgravity

Locatelli

Maier

2021

Front. Cell Dev. Biol.

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Mechanical cues contribute to the maintenance of a healthy endothelium, which is essential for vascular integrity. Indeed endothelial cells are mechanosensors that integrate the forces in the form of biochemical signals. The cytoskeleton is fundamental in sensing mechanical stimuli and activating specific signaling pathways. Because the cytoskeleton is very rapidly remodeled in endothelial cells exposed to microgravity, we investigated whether the disruption of actin polymerization by cytochalasin D in 1g condition triggers and orchestrates responses similar to those occurring in micro- and macro-vascular endothelial cells upon gravitational unloading. We focused our attention on the effect of simulated microgravity on stress proteins and transient receptor potential melastatin 7 (TRPM7), a cation channel that acts as a mechanosensor and modulates endothelial cell proliferation and stress response. Simulated microgravity downregulates TRPM7 in both cell types. However, 24 h of treatment with cytochalasin D decreases the amounts of TRPM7 only in macrovascular endothelial cells, suggesting that the regulation and the role of TRPM7 in microvascular cells are more complex than expected. The 24 h culture in the presence of cytochalasin D mimics the effect of simulated microgravity in modulating stress response in micro- and macro-vascular endothelial cells. We conclude that cytoskeletal disruption might mediate some effects of microgravity in endothelial cells.

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“…Copyright American Chemical Society 2018. Adapted from [11] with permission. Copyright Wikipedia 2014.…”

Section: Introductionmentioning

confidence: 99%

Cancer Diagnosis through SERS and Other Related Techniques

Blanco-Formoso

Alvarez-Puebla

2020

IJMS

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Cancer heterogeneity increasingly requires ultrasensitive techniques that allow early diagnosis for personalized treatment. In addition, they should preferably be non-invasive tools that do not damage surrounding tissues or contribute to body toxicity. In this context, liquid biopsy of biological samples such as urine, blood, or saliva represents an ideal approximation of what is happening in real time in the affected tissues. Plasmonic nanoparticles are emerging as an alternative or complement to current diagnostic techniques, being able to detect and quantify novel biomarkers such as specific peptides and proteins, microRNA, circulating tumor DNA and cells, and exosomes. Here, we review the latest ideas focusing on the use of plasmonic nanoparticles in coded and label-free surface-enhanced Raman scattering (SERS) spectroscopy. Moreover, surface plasmon resonance (SPR) spectroscopy, colorimetric assays, dynamic light scattering (DLS) spectroscopy, mass spectrometry or total internal reflection fluorescence (TIRF) microscopy among others are briefly examined in order to highlight the potential and versatility of plasmonics.

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Medical gallery of Blausen Medical 2014

Cited by 118 publications

References 32 publications

Neuroinflammatory mechanisms of post-traumatic epilepsy

Neuroinflammatory mechanisms of post-traumatic epilepsy

Cytoskeletal Remodeling Mimics Endothelial Response to Microgravity

Cancer Diagnosis through SERS and Other Related Techniques

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