Medical geochemistry of nitrates and human cancer in Sri Lanka

Dissanayake, C.B.; Weerasooriya, S. V. R.

doi:10.1080/00207238708710389

Cited by 27 publications

(9 citation statements)

References 19 publications

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“…The possible link between the consumption of drinking water with high nitrate content and the various human gastrointestinal cancer is already investigated by many authors (Dissanayake and Weerasooriya 1987;Bogovski and Bogovski 1981;National Research Council of America 1978). Such a link may also be significant in the etiology of EC in Golestan province of Iran.…”

Section: Resultsmentioning

confidence: 97%

Quality of drinking water and high incidence rate of esophageal cancer in Golestan province of Iran: a probable link

Keshavarzi

Moore

Najmeddin

et al. 2011

Environ Geochem Health

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Golestan province in north Iran is known to be a high-risk area for esophageal cancer (EC). Of a long list of multiple risk factors, this study focuses on a possible link between the epidemiologic patterns of EC and the anomalous concentration of some ions and elements in the drinking water sources. A total of 183 samples from 45 villages covering a wide range of EC mortality rates are collected and analyzed. The results demonstrate that NO(3)(-), SO(4)(2-), Sb, and Sr exceed the recommended maximum concentration level (MCL) in drinking water. This is more prominent in the villages with high esophageal cancer mortality rate, suggesting a possible link between EC incidence and water quality. Se concentration in drinking water increases from low to the high EC areas, a finding contrary to the expected trend. It is concluded that Se deficiency does not play a major role in the etiology of EC in the Golestan province. The statistical results obtained from Mann-Whitney and Kruskal-Wallis tests along with cluster analysis are consistent with the observed trend of EC mortality rate in Golestan province.

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Section: Resultsmentioning

confidence: 97%

Quality of drinking water and high incidence rate of esophageal cancer in Golestan province of Iran: a probable link

Keshavarzi

Moore

Najmeddin

et al. 2011

Environ Geochem Health

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“…Also these reservoirs are used for irrigation and other recreational activities and are also of an aesthetic value. As a developing country, Sri Lanka is gravely concerned on increasing reports of serious health problems resulting from unsafe drinking water especially in the dry zone of Sri Lanka (Dissanayake and Weerasooriya 1987; Dissanayake 1996, 2005; Rango et al 2015). Therefore, it is important to investigate the water quality from cyanobacterial aspect that could deteriorate water quality.…”

Section: Introductionmentioning

confidence: 99%

Genetic divergence among toxic and non-toxic cyanobacteria of the dry zone of Sri Lanka

2016

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Sri Lanka has rich cyanobacterial diversity, however, only few studies have been conducted to identify the potential toxin producers in water bodies used for human consumption. As the detection of cyanotoxin is vital in water quality management, a study was done by employing 16S rRNA gene to explore the genetic divergence, phylogenetic relationships and potential toxin producing cyanobacteria in reservoirs and well waters in the dry zone of Sri Lanka. Forty five, 16S rRNA gene sequences were assayed and phylogenetic tree was constructed. Among 45 isolates, 20 isolates were classified as unidentified cyanobacteria and considered as novel cyanobacterial genera. Of 25 identified isolates, seven isolates were identified up to species level. With 16S rRNA phylogeny, 20 unidentified cyanobacterial isolates were able to place on their taxonomic positions up to order level. Results revealed that water samples understudy had vast cyanobacterial diversity with potential microcystin (MC) and cylindrospermopsin (CYN) producers and eleven clusters clearly demonstrated five cyanobacterial orders with more than 90% similarity irrespective to their toxicity which showed the suitability of 16S rRNA gene for taxonomic differentiation. Sixteen isolates had the potential to produce MC and two isolates to produce CYN. Findings of the study confirm the rich cyanobacterial diversity and the divergence among the potential cyanotoxin producers in the dry zone water bodies of Sri Lanka.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-016-3680-5) contains supplementary material, which is available to authorized users.

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“…Strebel et al (1989) indicated that intensive use of fertilizer for crops is responsible for nitrate accumulation in both groundwater and surface waters. Irresponsible and excessive application of fertilizer introduce large amounts of nutrients to water bodies; this is especially the case in paddy cultivation (Dissanayake & Weerasooriya, 1987). Young et al (2010) stated that the fertilizer application is high in North Central part of Sri Lanka amounting to six to ten times in excess of the levels recommended by the government.…”

Section: Seasonal Variation Of Nitratesmentioning

confidence: 99%

Seasonal variation of water quality parameters in different geomorphic Channels of the upper Malwathu Oya in Anuradhapura, Sri Lanka

Perera¹,

Sundarabarathy

Sivananthawerl³

et al. 2015

Trop. Agric. Res.

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Medical geochemistry of nitrates and human cancer in Sri Lanka

Cited by 27 publications

References 19 publications

Quality of drinking water and high incidence rate of esophageal cancer in Golestan province of Iran: a probable link

Quality of drinking water and high incidence rate of esophageal cancer in Golestan province of Iran: a probable link

Genetic divergence among toxic and non-toxic cyanobacteria of the dry zone of Sri Lanka

Seasonal variation of water quality parameters in different geomorphic Channels of the upper Malwathu Oya in Anuradhapura, Sri Lanka

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