Economic, environmental, and psychosocial needs are common and wideranging among families cared for in primary care settings. Still, pediatric care delivery models are not set up to systematically address these fundamental risks to health. We offer a roadmap to help structure primary care approaches to these needs through the development of comprehensive and effective collaborations between the primary care setting and community partners. We use Maslow's Hierarchy of Needs as a well-recognized conceptual model to organize, prioritize, and determine appropriate interventions that can be adapted to both small and large practices. Specifically, collaborations with community organizations expert in addressing issues commonly encountered in primary care centers can be designed and executed in a phased manner: (1) build the case for action through a family-centered risk assessment, (2) organize and prioritize risks and interventions, (3) develop and sustain interventions, and (4) operationalize interventions in the clinical setting. This phased approach to collaboration also includes shared vision, codeveloped plans for implementation and evaluation, resource alignment, joint reflection and adaptation, and shared decisions regarding next steps. Training, electronic health record integration, refinement by using quality improvement methods, and innovative use of clinical space are important components that may be useful in a variety of clinical settings. Successful examples highlight how clinical-community partnerships can help to systematically address a hierarchy of needs for children and families. Pediatricians and community partners can collaborate to improve the well-being of at-risk children by leveraging their respective strengths and shared vision for healthy families.Pediatricians and primary care centers embrace the importance of identifying and acting on the economic, environmental, and psychosocial needs faced by their patients and families. Early recognition and action on these social determinants of health (SDH) are increasingly seen as critical, given their known impact on morbidity and mortality. [1][2][3] The related toxic stress model suggests that adverse childhood events often rooted in the SDH disrupt physiologic processes and cause such experiences to "get under the skin."This places children at risk for adverse health and developmental outcomes that can persist into adulthood. 4,5 Defining, identifying, and mitigating these toxic stressors could therefore promote childhood resilience, positive development, and health later in life.There are increasing calls to reshape pediatric care to better address the SDH. The American Academy of Pediatrics has outlined principles of patient-and family-centered care that include supporting and empowering children and families across the life