Medical Management of Obesity and its Complications

Caterson, Ian D.

doi:10.47102/annals-acadmedsg.v38n1p22

Cited by 15 publications

(6 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bioactive compounds of orange by-products were illustrated in Table (4). Data noticed that the total polyphenols, flavonoids, and carotenoids were higher in the pulp.…”

Section: Bioactive Compounds Of Orange By-productsmentioning

confidence: 97%

“…Corpulence is described as a BMI of over 25 kg/m2, and obesity as a BMI of over 30 kg/m2. These indicators serve as common reference points for evaluation; however, illness risks in all groups might gradually rise with decreasing BMI levels [4,5]. Over half of adults in developing countries are overweight, and 19.5% of adult populations are obese, according to the Organization for Economic Co-operation and Development member countries (OECD) [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Full Profiling of The Orange By-Products and Their Potential Effects with Chromium on Obesity Complications in Rats

AlTamim

2023

Egypt. J. Chem.

View full text Add to dashboard Cite

A disorder identified as obesity includes having too much body fat. It is a medical ailment that increases the risk of several syndromes and other health issues. Around the world, 19.5% of the adult population is obese, which is a widespread condition. The current study seeks to explore the chemical constitutes, bioactive substances, antioxidant activity, and impacts on obesity problems in rats of orange by-products, peel, and pulp integration with chromium. While orange pulp has larger amounts of carbohydrates, minerals (Mg, Fe, and Zn), vitamins (E, B1, and B6), and bioactive substances than orange peel, the latter has higher levels of total protein, fiber, minerals (Na, K, Ca, and P), vitamins (A and C), total polyphenols, flavonoids, and carotenoids. In contrast to the control normal group, rats fed a diet-stimulated obesity diet (DIO) had a higher body weight (416.76%), blood leptin (142.84%), glucose (95.17%), and hyperlipidemia (cholesterol (219.77%), triglycerides (131.22%), and low-density lipoprotein cholesterol (341.59%). Because orange peel and pulp contain antihyperlipidemic and anti-diabetic substances that lower serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol and raise high-density lipoprotein cholesterol, consuming them alone or in combination with chromium partially reversed these negative changes and decreased the likelihood of atherogenesis. When orange peels and pulp were combined with chromium, there showed noticeable synergistic effects. These results lay a foundation for the use of food industry by-products, with or without chromium, in the early detection and treatment of obesity. Additionally, the current study suggests adding orange by-product powder and/or extracts to our everyday meals, beverages, dietary supplements, and pharmaceutical formulations.

show abstract

“…Bioactive compounds of orange by-products were illustrated in Table (4). Data noticed that the total polyphenols, flavonoids, and carotenoids were higher in the pulp.…”

Section: Bioactive Compounds Of Orange By-productsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Full Profiling of The Orange By-Products and Their Potential Effects with Chromium on Obesity Complications in Rats

AlTamim

2023

Egypt. J. Chem.

View full text Add to dashboard Cite

show abstract

“…Saat ini terdapat pilihan obat dari golongan yang berbeda untuk menurunkan berat badan, tapi tidak semua obat tersebut terdapat di semua negara termasuk Indonesia, dan beberapa obat antiobesitas telah ditarik dari peredaran seperti fenfl uramin (derivat amfetamin), dexfl enfuramin karena efek sampingnya yang dapat membuat kecanduan dan merusak otak (3) , selain obat sintetik beberapa tumbuhan juga umum digunakan sebagai pelangsing seperti daun jati belanda, teh hijau, dan biji kopi hijau (4,5) .…”

Section: Bahan Dan Metodeunclassified

“…Hasil validasi dengan ligan unik lain yang diuji adalah XPE (3,6,9,12,15,18 bahwa terdapat empat senyawa dari biji kopi (Coff ea canephora.ex.A.Froehner) yang memiliki aktivitas menghambat enzim lipase pankreas yaitu asam klorogenat (asam 3-O-kafeoilkuinat), asam 5-O-kafeoilkuinat, asam 4,5-O-dikafeoilkuinat, asam 5-O-p-kumaroilkuinat. Penelitian ini merupakan lanjutan terhadap hasil uji in vivo penelitian sebelumnya terhadap aktivitas biji kopi hijau (14,15,16) dan penggunaan orlistat sebagai kontrol positif (3,4) . Nilai ChemPLP senyawa uji tertinggi berdasarkan hasil uji in silico yang dibandingkan dengan kontrol positif orlistat sebagai inhibitor lipase pankreas (-65,3258) yaitu senyawa Asam 4,5-O-dikaff eoilkuinat dengan nilai -85,3375.…”

Section: Hasil Dan Pembahasanunclassified

Analysis of Pancreatic Lipase Inhibitor Activity of Chlorogenic Acid Derivatives in Green Coffee Beans as Antiobesity using In Silico

Faridah

Sumaryono

Simanjuntak

et al. 2021

jifi

View full text Add to dashboard Cite

Obesity or overweight is defi ned as the accumulation of abnormal or excessive fat in adipose tissue whichcan damage health.Several plants have been used empirically as antiobesity.This study aims to obtain candidate antiobesity compounds that act as pancreatic lipase enzyme inhibitors, fi nd some amino acids that involved on the active site of the receptors and modelling the interactions of these active compounds at antiobesity receptors.The study start with internal validation of the receptors used (4DOQ), then carried out the docking process for the native ligand, comparison compound (Orlistat) and each test compound with the same receptor. The softwares used are PLANTS, YASARA, ChemSketch, and Pymol. The results of the 4DOQ receptor validation have an RMSD value of 1.7097 Ǻ. The results of the docking score for orlistat (-65.3258), and 4 active compounds namely chlorogenic acid (-69,3009), 5-O-caff eoylquinat acid (-70.6911), 4,5-O-dicaff eoilkuinic acid (-85 , 3375), 5-Op-coumaroilkuinic acid (-67,1886). Amino acids that play a role in the affi nity on the active side of the ligand bond with the pancreatic lipase receptor are THR21 (Threonine), ASN84 (Asparagine), GLY19 (Glycine), GLN156 (Glutamine), ALA85 (Alanine), ILE63 (Isoleucine), ARG62 (Arginine) . The conclusion of this study there are 4 chemical compounds in green coff ee beans that are active as antiobesity with the mechanism of action of the pancreatic lipase enzyme inhibitor, namely chlorogenic acid, 5-O-caff eoylquinic acid, 4,5-O-diphoeilquinic acid, 5-op-coumaroilquinic acid.

show abstract

“…Intensive lifestyle modification forms the cornerstone of therapy, as covered in the review article by Caterson. 14 The motivation level and receptiveness of the patient is pivotal to a successful outcome.…”

mentioning

confidence: 99%