Depending on the cause of a “dry eye” the treatment of some patients continues to be a problem. While treatment is usually limited to tear replacement, other therapies may be needed based on the cause of the dry eye syndrome. In the article, the literature is summarized as to the agents used to treat the “dry eye syndrome” basssed on the etiology. and presence of accompanying xerosis complications In addition, the article describes additional treatment trends such as anti-inflammatories, immunosuppressives, and drops stimulating tear production. Attention is also paid to the lacrimal pathway occlusion methods in using punctual plugs and other surgical methods. The authors advocate for the wide use of the different treatment methods available to treat complex “dry eye” syndrome patients.