Medical management of renal stone

Barnela, Shriganesh R.; Soni, Sachin; Saboo, Sonali S.; Bhansali, Ashish S.

doi:10.4103/2230-8210.93741

Cited by 25 publications

(11 citation statements)

References 32 publications

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“…Citrate is an important inhibitor for calcium and oxalate nucleation. Increase in the citrate levels in urine in all the treatment groups indicated the anti urolithiatic activity of the drug [ 18 ]. Increase in their values suggest urolithiatic activities whereas decrease suggest antiurolithiatic function.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Herbmed Plus in urolithic rats: An experimental study

Patankar

Fanthome

Bhalerao

2020

Journal of Ayurveda and Integrative Medicine

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Background In Ayurveda, several herbs and formulations are available for the treatment of Urolithiasis. However, they are not systematically evaluated for their safety, efficacy, indication and limitations. Herbmed Plus is one such herbal formulation that has been known for the management of urinary tract disorders. An attempt has been made to evaluate its efficacy on Urolithiasis. Objective To evaluate the efficacy and safety of Herbmed Plus in urolithic rats. Materials and methods A total of 60 Wistar albino rats were used for this study. The male and female rats were divided into five groups: disease control, test (dose 90 mg/kg), standard I (Cystone), standard II (Alkaston insta) and normal control (six in each group). Urolithiasis was induced using ethylene glycol 0.75% in drinking water for 28 days. The rats with urinary oxalate crystals were dosed with oral test or standard treatments for 28 days. Results All the animals appeared normal and showed no clinical signs of toxicity. None of the groups reported mortality or adverse effect on body weight and food consumption. The treatment with test drug showed improvement in the SGPT level and urine output (5.4 vs 3.47 mL/24 h). A drastic reduction in number of crystals were observed in male 0.5 vs 22 and female rats 0 vs 22.7 in test and disease group. The kidney lactate dehydrogenase, alkaline phosphatase, urinary phosphorus and calcium oxalate level decreased in the test and standard drug groups as compared to disease groups. Microscopy of the urine samples showed reduction in the number of crystals after treatment compared to the urolithic group. Increase in citrate levels in urine in all the treatment groups indicated anti-urolithiatic activity. The test group showed a 69.70% recovery in males and 47.57% recovery in female rats compared to the disease control group. Conclusion Herbmed Plus showed a significant reduction in oxalate synthesizing enzymes suggesting anti-urolithiatic activity and anti-inflammatory and regenerative property in cellular injury caused by crystal deposits.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Herbmed Plus in urolithic rats: An experimental study

Patankar

Fanthome

Bhalerao

2020

Journal of Ayurveda and Integrative Medicine

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“…It could significantly improve ECG and the relief of AP symptoms. The combination therapy of XFZYT and TAMs could also reduce the nitroglycerin use, improve blood HDL-C level which benefits patients with cardiovascular diseases [ 33 ], and decrease blood LDL-C, TG, and TC level which seemed as risk factors of cardiovascular disease [ 34 ]. No significant differences were identified on the incidence of adverse effects between XFZYT plus TAMs and TAMs.…”

Section: Discussionmentioning

confidence: 99%

The Usefulness of Xuefu Zhuyu Tang for Patients with Angina Pectoris: A Meta‐Analysis and Systematic Review

Qiu

Xiao

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Objective. To evaluate the efficacy of Xuefu Zhuyu Tang (XFZYT) for treating angina pectoris (AP). Methods. Six databases were searched (up to December, 2013). Eligible randomized controlled trials (RCTs) evaluating the efficiency of XFZYT plus traditional antianginal medications (TAMs) compared with TAMs alone in patients with AP were included. The outcomes were relief of anginal symptoms (RAS) and improvement of electrocardiogram (ECG) and blood high-density lipoprotein cholesterol (HDL-C) level. Result. Finally 14 RCTs were included. There were evidences that XFZYT combined with TAMs was more effective in improving RAS (RR = 1.29; 95% CI = [1.20, 1.38]), ECG (RR = 1.37; 95% CI = [1.22, 1.54]), and blood HDL-C level (MD = 0.29 mmol/L; 95% CI = [0.23, 0.35]) compared with TAMs alone. Our meta-analysis also showed the pooled number needed to treat (NNT) of the group with stable angina pectoris (SAP) was smaller in improving RAS (4.2 versus 5.7) and ECG (3.1 versus 5.5) compared with the group with both SAP and unstable angina pectoris (UAP). Conclusion. Combination therapy with XFZYT and TAMs is more effective in treating AP compared with TAMs alone. And XFZYT may be a more suitable choice for the treatment of SAP. However, the findings should be interpreted with caution due to the mediocre methodological quality of the included RCTs.

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“…Though this method is used more commonly in the US and some European countries as a first line of treatment for bigger stones, it involves more cost to the patient and is not without risk of damaging kidney or contributing to other form of renal injury, depending on the condition of the patient. 3 (International Journal of Current Advanced Research) Although the above-mentioned treatments are the first line of treatments for bigger stones globally, there is certain class of patients who still do not prefer surgical intervention for the disease for many reasons. These patients then rely on some orthodox medicine or even many superstitions and malpractices are followed to which the normal patient falls prey to.…”

Section: Introductionmentioning

confidence: 99%

Homeopathy as a saviour for urolithiasis: A narrative review shading light on pathophysiology of renal stones and homeopathy drugs

Mohod¹

2023

JPMHH

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Kidney stone disease is a crystal concretion formed generally within the kidneys. It is an accumulative urological disorder of human health, affecting about 12% of the world population. Higher risk of kidney failure which has been associated with end stage renal failure. Calcium oxalate, which forms at Randall's plaque on the renal papillary surfaces, is the most common type of kidney stone. Stone formation is highly prevalent, with rates of up to 14.8% and increasing, and a recurrence rate of up to 50% within the first 5 years of the initial stone incident. The formation of the stone is a complex process which results from numerous physiochemical events such as, super saturation, nucleation, growth, aggregation, and retention of urinary stone constituents within tubular cells. Several therapies are being performed for kidney stone treatment, including thiazide diuretics, allopurinol, painkillers, dietary changes, shock-wave treatment, ureterenooscopic and percutaneous nephrolithotomy, and ureterenooscopic and percutaneous nephrolithotomy in severe cases. However, the side effects that these treatments possess and reoccurrence of the disease have motivated researchers to search for better and safer options. Homeopathic drugs as well as several medicinal plants display antiurolithiatic activity and thus perform an important role in treatment of kidney stone disease. Therefore, the present review thereby wants to bring to the attention the wonderful results that homeopathy is offering in cases of urolithiasis in a very non-invasive and economical way which is not yet popularized.

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Medical management of renal stone

Cited by 25 publications

References 32 publications

Efficacy of Herbmed Plus in urolithic rats: An experimental study

Efficacy of Herbmed Plus in urolithic rats: An experimental study

The Usefulness of Xuefu Zhuyu Tang for Patients with Angina Pectoris: A Meta‐Analysis and Systematic Review

Homeopathy as a saviour for urolithiasis: A narrative review shading light on pathophysiology of renal stones and homeopathy drugs

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