Medical Management of Steroid-Induced Epidural Lipomatosis

Neurogenic claudication by epidural lipomatosis: a case report and review of literature

“…In cases of steroid administration Butcher [16] and later George [1] described that reduction in the dose of steroids can result in improvement of the clinical symptoms. In cases of idiopathic epidural lipomatosis, 2 modalities of treatment exist: conservative management with weight reduction and operative therapy consisting of decompressive laminectomy and fat debulking.…”

“…Spinal epidural lipomatosis is a rare condition defined by pathologic accumulation of fat in the extradural space of the vertebral canal; generally it is associated with the administration of exogenous steroids and has been reported in patients receiving immunosuppressive therapy after organ transplantation [1][2][3] and in patients requiring steroids for systemic disease (e.g. SLE [4,5], dermatomyositis [6], rheumatoid arthritis [7], chronic obstructive pulmonary disease [3,8]).…”

Corticosteroid-Induced Multifocal and Extensive Lipomatosis: A Case Report

“…It is based on the reduction or discontinuation of corticosteroid therapy if possible and the prescription of a hypocaloric diet, with restriction for four weeks of fast-acting carbohydrate [6,7]. This treatment helps to reduce the hyperinsulinemia and promotes lipolysis in adipose tissue [6,7].…”

Is epidural lipomatosis associated with abnormality of body fat distribution? A case report

“…In most cases such lipomatosis is related to local [8] or systemic [4,6,11] administration of glucocorticoids, and a few cases have been reported associated with Cushing's syndrome [9,12]. Idiopathic forms of the disease seem to occur in obese patients but their physiopathology remains unclear.…”