Medical memoranda. Toxic effect of podophyllum application in pregnancy.

Chamberlain, Michael J.; Reynolds, Alison; Yeoman, W. B.

doi:10.1136/bmj.3.5823.391

Cited by 83 publications

(19 citation statements)

References 6 publications

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“…Thus, practical management of women with anogenital warts in pregnancy consists of assiduous attempts to ablate the lesions using cryotherapy or TCA. Podophyllin and podophyllotoxin are contraindicated in pregnancy (Chamberlain et al, 1972). The product licence for imiquimod does not include pregnancy and its safety is not established.…”

Section: Management Of Genital Warts In Pregnancymentioning

confidence: 97%

Therapy for genital human papillomavirus-related disease

Lacey

2005

Journal of Clinical Virology

142

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Section: Management Of Genital Warts In Pregnancymentioning

confidence: 97%

Therapy for genital human papillomavirus-related disease

Lacey

2005

Journal of Clinical Virology

142

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“…Skin lesions can become malignant after repeated applications of podopyllin. Podophyllin is known to produce polyneuritis and its application in pregnant women with genital warts is contraindicated because of its known teratogenic effect (Chamberlain et al, 1972). Podophyllin can induce severe local reaction in patients withautoimmune diseases, diabetes, andin those being treated with corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Cryosurgery of genital warts in cases in which podophyllin treatment failed or was contraindicated.

Ghosh¹

1977

Sexually Transmitted Infections

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SUMMARY A total of 56 cases with warts in which podophyllin treatment was either contraindicated or a failure, were treated with nitrous oxide using a Keymed 500 cryosurgical appliance. Forty-three patients who completed treatment were followed-up for three months. Thirty-seven of these had received applications of podophyllin twice weekly for an average period of three months before cryosurgery. The remaining cases in whom podophyllin was considered to be contraindicated included five with vulval warts (two were pregnant, two were bronchial asthmatics taking oral prednisolone, and one was taking oral clomiphene citrate), and a diabetic patient with penile warts. Thirty-two were cured and 11 relapsed. The latter were re-treated at the end of the follow-up period with two freezing cycles of 45 seconds at an interval of 30 minutes. Seven were cured and the remaining four men who failed to respond belonged to the podophyllin-resistant group and included three with meatal warts and one homosexual with anogenital warts. Cryosurgery gave a cumulative success rate of 91 %. A single freezing cycle was free from complications but a double freezing cycle was often followed by severe local reaction.

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“…The drug therefore deserves a trial in large lesions before surgical intervention. However, because of its known systemic toxicity, it should be avoided in cases of extensive genital lesions especially in pregnant women (Chamberlain et al, 1972).…”

Section: Discussionmentioning

confidence: 99%