Medical methods for first trimester abortion

Kulier, Regina; Gülmezoglu, A Metin; Hofmeyr, G Justus; Cheng, Liang; Campana, A.

doi:10.1002/14651858.cd002855.pub2

Cited by 13 publications

(6 citation statements)

References 55 publications

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“…Side effects of misoprostol were minimal in this study. Vaginal administration was preferred to the oral route to reduce gastrointestinal side effects [15–17]. Although overall bioavailability is higher with vaginal misoprostol, peak plasma concentration is 1.6 times higher with oral than with vaginal administration [18].…”

Section: Discussionmentioning

confidence: 99%

Medical vs. surgical evacuation of first‐trimester spontaneous abortion

Moodliar

Bagratee

Moodley

2005

Intl J Gynecology & Obste

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Section: Discussionmentioning

confidence: 99%

Medical vs. surgical evacuation of first‐trimester spontaneous abortion

Moodliar

Bagratee

Moodley

2005

Intl J Gynecology & Obste

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“…MVA has been clinically proven to be as effective as sharp curettage when employed in the management of firsttrimester abortions. MVA procedure had no different complication when compared with those of traditional curettage in regard to cervical injuries, febrile morbidity, blood transfusion, or incomplete or repeated uterine evacuation procedures [12].In 2003, the World Health Organization [13] recommended MVA for performing a first-trimester termination of pregnancy. It is especially valuable in low resource settings where electricity and surgical suites are not widely available.…”

Section: Introductionmentioning

confidence: 99%

MANUAL VACUUM ASPIRATION VERSUS DILTATION AND CURETTGE TERMINATION OF FIRST TRIMESTER ABORTION AMONG WOMEN ADMITTED AL-SADAQA TEATCHING HOSPITAL, ADEN JAN1st DECEMBER 31st 2020

Al-Daweel,

Al-Kaaky

2024

Electron. J. Univ. Aden Basic Appl. Sci.

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Early pregnancy failure is a medical complication and major health problem across the globe. The aim of this study is to compare manual vacuum aspiration (MVA) and dilatation and curettage (D&C) for first trimester abortion, in terms of the efficiency of eliminating retain product of conceptus, frequency of complications, duration of the procedure, and duration of patients' hospitalization. This is a prospective comparative descriptive study performed at Al-Sadaqa Teaching Hospital. Over a period from 1st Jan 2020 to 31st December 2020, a total of 143 women, these patients either MVA group (n=72) or D&C group (n=71). Presented with spontaneous abortion and gestational age less than 12 weeks, patent cervix, and no signs of septic abortion, hemoglobin ≥9 g/dl and no bleeding disorder. Data was collected on prescribed questionnaire. The total number of abortion 637 in compare to 259 (40.7%) patient with first trimester abortion, 143 patients was included in this study, MVA group (n =72) and D&C group (n=71). The distribution in respect to the age, parity & gestational age was similar in both groups. The mean duration of procedure was significantly higher (P<0.05) in D&C group compared to MVA group. The duration of hospital stay was significantly lower (P<0.05) in MVA group compared to D&C group. MVA group showed the least incidence of complications regarding the amount of blood loss, and cervical laceration. Complete evacuation was achieved in 95.8% in MVA vs. 98.6% in D&C group with no statically significant (P=0.304). MVA is as effective as popular dilatation and curettage for treatment of early pregnancy failure while it need less time consuming, requires a shorter hospital stay and subsequently costs less. It does not require general anesthesia and complication rate is less than dilatation and curettage. So it can be easily accessible to the woman of both rural and urban societies belonging to any socioeconomic strata especially where high tech equipment and power supply are not available.

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“…1 Cervical dilatation before suction evacuation is probably the most critical step of the procedure. 2 Mechanical cervical dilatation in the first trimester has been associated with some risk of cervical injury and incompetence of the cervix resulting in premature labor and spontaneous abortion. Several chemical agents have been used in trying to prevent this mishap in the last few years.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of efficacy and safety of intramuscular carboprost and intravaginal misoprostol for cervical priming prior to first trimester surgical abortion

Mathuriya

Verma

Pandey

2019

Int J Reprod Contracept Obstet Gynecol

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Background: MTP Act no 34 of 1971 has been defined as Legal termination of pregnancy before the age of viability of fetus that is 20 weeks of gestation. There is a need to find a medical agent which can help in the process of abortion by speeding it up, with minimal side effects. The objective of this study was to compare the efficacy of I.M carboprost and intravaginal Misoprostol and to evaluate the safety profile of I.M carboprost and Intravaginal Misoprostol. To compare the cervical dilatation caused by I.M carboprost and intravaginal Misoprostol and to compare the blood loss and adverse effects of I.M carboprost and Intravaginal Misoprostol.Methods: Prospective randomized experimental study including pregnant women up to 12 weeks of gestation opting for M.T.P. Study conducted on 200 patients selected from patients admitted in MGM Medical College and M.Y. Hospital, Indore and Kalyanmal Hospital, Indore during the period July 2014 to March 2015. They were randomly divided into 2 groups. Group A who received intramuscular injection of 250 mcg of caboprost or Group B,which received 400 mcg of vaginal Misoprostol 4 hours prior to suction evacuation.Results: Intravaginal misoprostol achieves better cervical dilatation compared I.M carboprost which is statistically significant. Misoprostol is associated with higher blood loss as compared to I.M carboprost which is associated with nausea/vomiting & more likelihood of loose stools and abdominal cramps which is proved statistically.Conclusions: Intravaginal misoprostol is associated with higher blood loss as compared to I.M carboprost which is significant but intravaginal misoprostol achieves more cervical dilatation and causes less adverse events than I.M carboprost which is statistically more significant and therefore intravaginal misoprostol is the drug of choice for cervical priming prior to surgical abortion in terms of both efficacy and safety.

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Medical methods for first trimester abortion

Cited by 13 publications

References 55 publications

Medical vs. surgical evacuation of first‐trimester spontaneous abortion

Medical vs. surgical evacuation of first‐trimester spontaneous abortion

MANUAL VACUUM ASPIRATION VERSUS DILTATION AND CURETTGE TERMINATION OF FIRST TRIMESTER ABORTION AMONG WOMEN ADMITTED AL-SADAQA TEATCHING HOSPITAL, ADEN JAN1st DECEMBER 31st 2020

A comparative study of efficacy and safety of intramuscular carboprost and intravaginal misoprostol for cervical priming prior to first trimester surgical abortion

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