Medical mycology in India

Das-Gupta, S. N.; Shome, S. K.; Majumdar, S. S.

doi:10.1007/bf02089932

Cited by 11 publications

(1 citation statement)

References 21 publications

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“…5 -8 Onychomycosis occurs more frequently than subcutaneous and systemic mycoses and remains a therapeutic problem in tropical and subtropical countries. 9 Synthetic antifungal agents are largely nonrenewable petro-products that are non-biodegradable and cause adverse effects and residual toxicity. 10 Thus, in a meaningful search for new treatments with better and cheaper substitutes, plant resources are the natural choice.…”

Section: Introductionmentioning

confidence: 99%

Utilization of essential oil as natural antifungal against nail‐infective fungi

Patra

Shahi

Midgely

et al. 2002

Flavour & Fragrance J

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During antifungal screening of some essential oils, Foeniculum vulgare exhibited the strongest activity, completely inhibiting the mycelial growth of the nail-infective fungi, Trichophyton rubrum, T. mentagrophytes and Scytalidium dimidiatum. The essential oil was found to be fungicidal at 0.2, 0.4 and 0.5 µl/ml concentrations. The oil was efficiently active against heavy doses of inoculum at minimum fungicidal concentrations. The fungicidal activity of the oil was found to be thermostable up to 80°C, with no descramble decrease in activity after 48 months of storage. The oil also showed a broad fungitoxic spectrum, inhibiting the mycelial growth of other nail-infective fungi, viz. Aspergillus flavus, A. fumigatus, A. niger, A. ustus, Candida albicans, Epidermophyton floccosum, Microporum audouinii , M. canis, M. gypseum, M. nanum, Rhizopus nigricans, Trichophyton tonsurans and T. violaceum. Moreover, it did not exhibit any adverse effects on mammalian skin and nails up to 5% concentration. As such, the oil has a potential use as an effective herbal chemotherapeutic after undergoing successful clinical trials.

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Section: Introductionmentioning

confidence: 99%

Utilization of essential oil as natural antifungal against nail‐infective fungi

Patra

Shahi

Midgely

et al. 2002

Flavour & Fragrance J

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Black Grain Mycetoma of Foot

Kandhari¹,

Mohapatra²,

Sehgal³

et al. 1964

Arch Dermatol

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Antifungal efficacy of Taxodium and Mentha oils against some human pathogenic fungi

Pandey

Shahi

Singh

et al. 2002

Flavour & Fragrance J

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During antifungal screening of essential oils of some higher plants against human pathogenic fungi, oils of Mentha spicata (L.) and Taxodium distichum (L.) Rich. exhibited significant activity against the test pathogens Epidermophyton floccosum (Harz) Langeron and Milochevitch, Microsporum gypseum (Bodin.) Guiart and Gregoraki and Microsporum nanum Fuentes. The minimum inhibitory concentrations (MICs) of the oil of M. spicata were found to be 1.8 µl/ml for E. floccosum, M. gypseum and M. nanum. In the case of T. distichum the minimum inhibitory concentrations (MICs) were found to be 2.0 µl/ml for M. gypseum and 2.5 µl/ml for E. floccosum and M. nanum. The oils also exhibited potency against heavy doses of inoculum (30 mycelial discs, each 5 mm in diameter) at these MICs concentrations. On comparison with the synthetic antifungal drugs myconazole and ketaconazole, these oils were found to be more effective.

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Medical mycology in India

Cited by 11 publications

References 21 publications

Utilization of essential oil as natural antifungal against nail‐infective fungi

Utilization of essential oil as natural antifungal against nail‐infective fungi

Black Grain Mycetoma of Foot

Antifungal efficacy of Taxodium and Mentha oils against some human pathogenic fungi

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