Medical near Infrared Spectroscopy 35 Years after the Discovery

Ferrari, Marco; Norris, Karl H.; Sowa, Michael G.

doi:10.1255/jnirs.982

Cited by 17 publications

(20 citation statements)

References 18 publications

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“…47 Medical NIR spectroscopy applied to in vivo medical applications dates back to 1977 when Frans Jöbsis reported brain tissue can be measured within the NIR range (700-1000 nm). 11 This enabled real-time, non-invasive analysis of haemoglobin oxygenation. 11 The main advantages of NIR spectroscopy for medical applications are that it does not have any side-effects, can be used in real-time and that it is cost-effective and portable.…”

Section: Soilmentioning

confidence: 99%

“…NIR spectroscopy is applied as a tool during process analytical technology (PAT) and quality control (QC) as the method of choice in various fields, i.e. agriculture, 4 food, 5 bioactives, 6 pharmaceuticals, 7 petrochemicals, 8 textiles, 9 cosmetics, 10 medical applications 11 and chemicals such as polymers. 12 NIR spectroscopy is also increasingly used in aquaphotomics, 13 which has been introduced as a new approach to describe and visualise the interaction of water with solvents with visible and nearinfrared (vis-NIR) light absorbance patterns.…”

Section: Introductionmentioning

confidence: 99%

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Near-infrared spectroscopy and hyperspectral imaging: non-destructive analysis of biological materials

2014

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Near-infrared (NIR) spectroscopy has come of age and is now prominent among major analytical technologies after the NIR region was discovered in 1800, revived and developed in the early 1950s and put into practice in the 1970s. Since its first use in the cereal industry, it has become the quality control method of choice for many more applications due to the advancement in instrumentation, computing power and multivariate data analysis. NIR spectroscopy is also increasingly used during basic research performed to better understand complex biological systems, e.g. by means of studying characteristic water absorption bands. The shorter NIR wavelengths (800-2500 nm), compared to those in the mid-infrared (MIR) range (2500-15 000 nm) enable increased penetration depth and subsequent non-destructive, non-invasive, chemical-free, rapid analysis possibilities for a wide range of biological materials. A disadvantage of NIR spectroscopy is its reliance on reference methods and model development using chemometrics. NIR measurements and predictions are, however, considered more reproducible than the usually more accurate and precise reference methods. The advantages of NIR spectroscopy contribute to it now often being favoured over other spectroscopic (colourimetry and MIR) and analytical methods, using chemicals and producing chemical waste, such as gas chromatography (GC) and high performance liquid chromatography (HPLC). This tutorial review intends to provide a brief overview of the basic theoretical principles and most investigated applications of NIR spectroscopy. In addition, it considers the recent development, principles and applications of NIR hyperspectral imaging. NIR hyperspectral imaging provides NIR spectral data as a set of images, each representing a narrow wavelength range or spectral band. The advantage compared to NIR spectroscopy is that, due to the additional spatial dimension provided by this technology, the images can be analysed and visualised as chemical images providing identification as well as localisation of chemical compounds in non-homogenous samples.

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Section: Soilmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy and hyperspectral imaging: non-destructive analysis of biological materials

2014

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“…This limitation is less significant in young children, since, with thinner skull, the partial pathlength in the brain increases. In 2012, the Journal of Near Infrared Spectroscopy Special Issue on Medical Application nicely summarized the most important aspects of the medical NIRS in 16 articles (mainly review articles) [8,9]. Brain/muscle oximetry and functional NIRS (fNIRS) represented the most established clinical and/or basic research areas.…”

Section: Introductionmentioning

confidence: 99%

“…The hemodynamic signals are normally precisely related to the underlying neuronal activity through neurovascular coupling mechanisms that ensure the supply of glucose and oxygen to neurons [14] but also provide a heat sink to help cool the brain and removal of waste by-products [15,16]. In addition, the neurovascular coupling plays a key role in In 2012, the Journal of Near Infrared Spectroscopy Special Issue on Medical Application nicely summarized the most important aspects of the medical NIRS in 16 articles (mainly review articles) [8,9]. Brain/muscle oximetry and functional NIRS (fNIRS) represented the most established clinical and/or basic research areas.…”

Section: Introductionmentioning

confidence: 99%

A Mini-Review on Functional Near-Infrared Spectroscopy (fNIRS): Where Do We Stand, and Where Should We Go?

Quaresima

Ferrari

2019

Photonics

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This mini-review is aimed at briefly summarizing the present status of functional near-infrared spectroscopy (fNIRS) and predicting where the technique should go in the next decade. This mini-review quotes 33 articles on the different fNIRS basics and technical developments and 44 reviews on the fNIRS applications published in the last eight years. The huge number of review articles about a wide spectrum of topics in the field of cognitive and social sciences, functional neuroimaging research, and medicine testifies to the maturity achieved by this non-invasive optical vascular-based functional neuroimaging technique. Today, fNIRS has started to be utilized on healthy subjects while moving freely in different naturalistic settings. Further instrumental developments are expected to be done in the near future to fully satisfy this latter important aspect. In addition, fNIRS procedures, including correction methods for the strong extracranial interferences, need to be standardized before using fNIRS as a clinical tool in individual patients. New research avenues such as interactive neurosciences, cortical activation modulated by different type of sport performance, and cortical activation during neurofeedback training are highlighted.

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“…Applications of Near-infrared spectroscopy (NIRS) in understanding tissue metabolism in clinical, sports and ergonomics-related literature are rapidly growing (e.g., Bhambhani 2010, Harrison et al, 2010, McGorry et al, 2010, Maikala 2012, Neary 2004, Perrey et al, 2010aand 2010b. Topical special issues on NIRS in different research domains are perfect examples of its popularity and utility (Maikala and Hargens 2010, Elwell and Cooper 2011, Ferrari et al, 2012. Lately, point-of-care or 'near-patient' testing has become a healthcare delivery issue of utmost importance, specifically in settings such as primary care, home healthcare, emergency medicine and in low resource or remote areas (Price and Kricka 2007).…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Spectroscopy and Its Potential for Point-Of-Care Testing

Maikala

2017

ISER

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Point-of-care or ‘near-patient’ testing has received attention in recent years for its usefulness in rapid and reliable delivery of healthcare to a patient in a variety of clinical settings. Near-infrared spectroscopy (NIRS)-derived optical biomarkers (e.g., tissue oxygen saturation) have been utilized to monitor tissue vascularity and oxygenation status continuously in normal and patient populations. Despite its ease of use and modest cost, the NIRS modality is still not at point-of-care use in the healthcare sector as extensively as other physiological modalities such as Pulse Oximetry. This short communication examines the case for point-of-care testing with two examples of FDA-approved NIRS systems, and discusses the feasibility and implementation of the NIRS modality as a point-of-care technology.

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Medical near Infrared Spectroscopy 35 Years after the Discovery

Cited by 17 publications

References 18 publications

Near-infrared spectroscopy and hyperspectral imaging: non-destructive analysis of biological materials

Near-infrared spectroscopy and hyperspectral imaging: non-destructive analysis of biological materials

A Mini-Review on Functional Near-Infrared Spectroscopy (fNIRS): Where Do We Stand, and Where Should We Go?

Near-Infrared Spectroscopy and Its Potential for Point-Of-Care Testing

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