Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review

Abstract

Drug-induced liver injury encompasses a spectrum of diseases ranging from mild biochemical abnormalities to acute liver failure; example of this scenery is hepatotoxicity caused by the first-line antituberculous drugs isoniazid, rifampin and pyrazinamide, which are basic for treatment of drug-sensible and drug-resistant tuberculosis. In the search for pharmacological alternatives to prevent liver damage, antitubercular drugs have been the subject of numerous studies and published reviews, a great majority of them carried out by Asian countries. At the same time, hepatoprotectors from plant source are now emerging as a possible alternative to counteract the toxic effects of these therapeutic agents. The present review aims to highlight the most recent studies on the subject, based information published in scientific databases such as Scopus and PubMed.

Impact of raw cocoa and chocolate on lipid profile and liver function in alcohol-induced toxicity Wister rats

“…All of these findings in agreement with previous reports by Arellanes and others whom stated that, the presence of N-Caffeoyldopamine inTheobroma cacao tree , This natural compound showed a protective effect due to its antioxidant activity by increasing superoxide dismutase and glutathionelevels in hepatic tissue and significantly lowering the liver-enzyme levels (AST, ALT and ALP) (Arellanes et al 2016). …”

“…Metabolic activation of carcinogens and the activity of vascular endothelial growth factor were inhibited by the actions of polyphenols (Andujar et al 2012). The NCaffeoyldopamine isolated fromTheobroma cacao tree, have hepatoprotective effect due to its antioxidant activity by increasing superoxide dismutase and glutathionelevels in hepatic tissue and significantly lowering the liver-enzyme levels (AST, ALT and ALP), as well as the lipid peroxidation in liverthrough the CYP4502E1 down-regulation (Arellanes et al 2016) ; so cocoa in both forms; raw and processed was used in medicine to treat various diseases like diabetes mellitus, cardiovascular diseases and cancer (Andujar et al 2012). Objective of study: The current study conducted to evaluate the biochemical and histopathological sections of liver among groups treated with cocoa and chocolate compared to standard drug (prednisolone).…”

An Evaluation of the In Vitro Roles and Mechanisms of Silibinin in Reducing Pyrazinamide- and Isoniazid-Induced Hepatocellular Damage

“…Administration of these combinations have led to increased membrane lipid peroxidation levels (Eminzade et al, 2008), increased serum levels of liver enzymes (Srivastava et al, 2008;Tasduq et al, 2005), and reduced antioxidant protein levels (Tasduq et al, 2005;Victorrajmohan et al, 2005). Notably, the search for strategies to reduce PZAand INH-induced hepatotoxicity is further underscored by the first-line status of the PIER regimen in ATT with few safer and equally efficacious alternatives (Jiménez-Arellanes et al, 2016;Zumla et al, 2013).…”

“…Among the nutraceuticals that have been explored for their hepatoprotective potential, silibinin is the gold standard (Surai, 2015). Silibinin is a herbal product derived from milk thistle that has been postulated to protect against liver injury caused by various chemotherapeutic (Patel et al, 2010) and toxic agents (Fanoudi et al, 2018;Jiménez-Arellanes et al, 2016;Ma et al, 2016). Two factors contribute to silibinin's popularity over other chemical drugs in liver disease: it has low toxicity (Flora et al, 1998) and exhibits a broad spectrum of hepatoprotective mechanisms (Polachi et al, 2016;Rodriguez-Garcia et al, 2017;Vargas-Mendoza et al, 2014).…”

Malva: Food, Medicine and Chemistry

“…Among these synthetic drugs and chemicals, both organic, but mainly inorganic chemicals are widely used, and have some severe adverse effects. 372 376 Use of Malva species for constipation relief is known in most traditional medicines of Asia (M. neglecta 36,41,52,59 , M. parviflora 67 and M. sylvestris 108,110,115 ). This activity is recently investigated by several groups.…”