Medical rapid prototyping and 3D CT in the manufacture of custom made cranial titanium plates

Winder, John; Cooke, R. S.; Gray, J; Fannin, T. F.; Fegan, T

doi:10.1080/030919099294401

Cited by 129 publications

(65 citation statements)

References 8 publications

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“…Recently, rapid prototyping (RP) technology has been used to fabricate physical models of hard tissues, tissue scaffolds, and custom-made tissue implant prostheses (Potamianos et al, 1998;Holck et al, 1999;Winder et al, 1999). RP technology has been used to produce novel scaffolds with controllable porosity and channel sizes, potentially allowing for vacularization (Zein et al, 2002).…”

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confidence: 99%

Cell and organ printing 2: Fusion of cell aggregates in three‐dimensional gels

et al. 2003

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We recently developed a cell printer (Wilson and Boland, 2003) that enables us to place cells in positions that mimic their respective positions in organs. However, this technology was limited to the printing of two-dimensional (2D) tissue constructs. Here we describe the use of thermosensitive gels to generate sequential layers for cell printing. The ability to drop cells on previously printed successive layers provides a real opportunity for the realization of three-dimensional (3D) organ printing. Organ printing will allow us to print complex 3D organs with computer-controlled, exact placing of different cell types, by a process that can be completed in several minutes. To demonstrate the feasibility of this novel technology, we showed that cell aggregates can be placed in the sequential layers of 3D gels close enough for fusion to occur. We estimated the optimum minimal thickness of the gel that can be reproducibly generated by dropping the liquid at room temperature onto a heated substrate. Then we generated cell aggregates with the corresponding (to the minimal thickness of the gel) size to ensure a direct contact between printed cell aggregates during sequential printing cycles. Finally, we demonstrated that these closely-placed cell aggregates could fuse in two types of thermosensitive 3D gels. Taken together, these data strongly support the feasibility of the proposed novel organ-printing technology. Anat Rec Part A 272A: 497-502, 2003.

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Cell and organ printing 2: Fusion of cell aggregates in three‐dimensional gels

et al. 2003

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“…Today's computer-aided technologies, medical imaging, modern design and manufacturing have further assisted in those advances and created new possibilities in the development of tissue engineering. Such possibilities include, for example, using noninvasive computed tomography (CT) or magnetic resonance imaging (MRI) techniques to generate tissue structural views for 3-D anatomical model, for tissue classification and trauma/tumor identification [24][25][26][27][28][29][30][31][32][33], using computer-aided design/computer-aided manufacturing (CAD/CAM) and rapid prototyping (RP) technology to fabricate the physical models of hard tissues, tissue scaffolds, and the custom-made tissue implant prostheses [34][35][36][37][38][39][40][41][42], and applying the anatomical and physical modeling for reconstructive surgeons and tissue implementation [43][44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Recent development on computer aided tissue engineering — a review

Sun¹,

Lal²

2002

Computer Methods and Programs in Biomedicine

333

164

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The utilization of computer-aided technologies in tissue engineering has evolved in the development of a new field of computer-aided tissue engineering (CATE). This article reviews recent development and application of enabling computer technology, imaging technology, computer-aided design and computer-aided manufacturing (CAD and CAM), and rapid prototyping (RP) technology in tissue engineering, particularly, in computer-aided tissue anatomical modeling, three-dimensional (3-D) anatomy visualization and 3-D reconstruction, CAD-based anatomical modeling, computer-aided tissue classification, computer-aided tissue implantation and prototype modeling assisted surgical planning and reconstruction.

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“…As an extension to medical modelling, CAD tools have been used to correct virtual models of defective bony anatomy, with the resulting physical models being regularly used as jigs for lab-based implant fabrication (Winder, 1999). Additionally, their use has extended to directly designing mould tools for soft-tissue prostheses to shorten the patient's time in-clinic and reduce costs (Eggbeer et al, 2012).…”

Section: Anatomical Models and Digital Reconstructionmentioning

confidence: 99%

Additively manufactured maxillofacial implants and guides – achieving routine use

Peel

Eggbeer

2016

Rapid Prototyping Journal

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Structured Abstract:Purpose: The technical efficacy of, and clinical benefits from using Computer Aided Design (CAD) and Additive Manufacturing (AM) in the production of patient-specific devices (implants and guides) has been established. Despite this, they are still not in routine clinical use. With AM equipment and CAD tool costs largely outside of the clinician's or designer's control, the opportunity exists to explore design process improvement routes to facilitate routine health service implementation. This paper identifies the key design process factors acting as drivers or barriers to this aim.Methodology / approach: A literature review, new data from three separate clinical case studies, and experience from an institute working on collaborative research and commercial application of CAD/AM in the maxillofacial specialty were analysed to extract a list and formulate models of design process factors.Findings: A semi-digital design and fabrication process is currently the lowest cost and shortest duration for cranioplasty implant production. The key design process factor to address is the fidelity of the device design specification. Implications / limitations:Further research into the relative value of, and best methods to address the key factor is required; in order to work towards the development of new design tools. A wider range of benchmarked case studies is required to better generalise findings beyond one implant type.Originality / value: Design process factors are identified (building on previous work largely restricted to technical and clinical efficacy). Additionally, three implant design and fabrication workflows are directly compared for costs and time. Unusually, a design process failure is detailed. A new model is proposed -describing design process factor relationships and the desired impact of future design tools.

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Medical rapid prototyping and 3D CT in the manufacture of custom made cranial titanium plates

Cited by 129 publications

References 8 publications

Cell and organ printing 2: Fusion of cell aggregates in three‐dimensional gels

Cell and organ printing 2: Fusion of cell aggregates in three‐dimensional gels

Recent development on computer aided tissue engineering — a review

Additively manufactured maxillofacial implants and guides – achieving routine use

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