Medical Rehabilitation System for Senior Patients with Severe Craniocerebral Injury in the Megalopolis

Shcherbuk, Yu. A.; Zacharov, V. I.; Shcherbuk, A. Yu.; Donskov, V. V.; Smochilin, A. G.; Черепанова, Екатерина; Kushnirenko, Ya. N.

doi:10.1134/s2079057019030160

Cited by 1 publication

(1 citation statement)

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“…Among the treatments at different temperatures, the treatment group of maintaining 30°C hypothermia had the best effect. [24] TTM belongs to physiotherapy, which aims to lower the temperature, protect brain tissue and improve the prognosis of patients. TTM can effectively reduce the damage of brain tissue cells caused by toxic substances produced by human body, remarkably reduce the synthesis and release of glutamate after TBI.…”

Section: Discussionmentioning

confidence: 99%

Target temperature management and therapeutic hypothermia in sever neuroprotection for traumatic brain injury: Clinic value and effect on oxidative stress

Wang

Huang²,

Tian³

et al. 2023

Medicine

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This study is to explore the application of target temperature management and therapeutic hypothermia in the treatment of neuroprotection patients with severe traumatic brain injury and its effect on oxidative stress. From February 2019 to April 2021, 120 patients with severe traumatic brain injury cured were selected in our hospital. The patients were randomly divided into control and experimental groups. The control group accepted mild hypothermia therapy. The experimental group took targeted temperature management and mild hypothermia therapy. This study compared the prognosis, National Institute of Health Stroke Scale (NIHSS) score, oxidative stress level, brain function index and the incidence of complications in different groups. The prognosis of the experimental group was better (P < .05). After treatment, the NIHSS score lessened. The NIHSS score of the experimental group was lower at 3 and 6 weeks after treatment (P < .05). Following treatment, the level of superoxide dismutase-1 in the experimental group was higher and the level of malondialdehyde was lower (P < .05). After treatment, the brain function indexes of patients lessened. The experimental group's myelin basic protein, neuron specific enolase and glial fibrillary acidic protein indexes were lower (P < .05). The incidences of pendant pneumonia, atelectasis, venous thrombosis of extremities and ventricular arrhythmias in the experimental group were remarkably lower (P < .05). Targeted temperature management and mild hypothermia treatment can improve neurological function, maintain brain cell function, and reduce stress-reactions risk. The incidence of complications during hospitalization was reduced.Abbreviations: GCS = Glasgow Coma Scale, GFAP = glial fibrillary acidic protein, MBP = myelin basic protein, NSE = neuron specific enolase, NIHSS = National Institute of Health Stroke Scale, STBI = severe traumatic brain injury, TBI = traumatic brain injury, TTM = targeted temperature management.

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Section: Discussionmentioning

confidence: 99%