Introduction: Addiction to tobacco products such as cigarettes, hookahs, etc. can be caused by psychosocial abnormalities that cause physical and psychological dependence of a person who is affected by various factors. This study was conducted in 2017 to investigate the association of addiction and quality of life in students of Urmia University of Medical Sciences. Materials and Methods: This cross-sectional study was on 630 students of Urmia University of Medical Sciences in 2016-2017. Data were collected using demographic information questionnaire, identification of people at risk of Anise addiction and WHO quality of life questionnaire. Data were collected by SPSS18 and analyzed using linear regression, correlation test and descriptive statistics. Finding: In this study, the average age of the participants was 22± 13/3 years and (44.4) 280 were male participants, Most of the students participated in the entrance study in 2016-2017 and (91.7%) 578 were single participants, most of the students participating in the study were The School of Medicine (48.3) was 304 and the lowest of the School of Health (11) was 69 The highest average in the sub-abuse tendency to addiction, depression, and helplessness 692 (23.87) was. Results: The results showed that the highest quality of life for women and men had the highest drug abuse trend and the tendency to drug abuse and there was a significant relationship between quality of life. Keywords: Abuse tendency to addiction, Quality of Life, Medical Students, Urmia, depression, helplessness.