Medical Treatment for Dry Eye in Japan

Watanabe, Hitoshi

doi:10.1167/iovs.18-24130

Cited by 16 publications

(12 citation statements)

References 60 publications

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Section: Considerations Of the Management Of Cataract Surgery Associamentioning

confidence: 99%

“…109,110 The two mucin secretagogues eye drops, diquafosal and rebamipide, are now approved for use in Japan and South Korea for the treatment of DED and studies have recently demonstrated their efficacy in the treatment of DED following cataract surgery. 111 Diquafosal is a P2Y2 receptor agonist and laboratory studies have shown that it can increase mucin secretion and reduce the rate of corneal epithelial cell loss. 112,113 In a RCT by Miyake and Yokoi in 154 eyes, 11 patients with DED following cataract surgery were randomized to receive either Diquafosal 3% drops 6 times a day for 4 weeks or artificial tears 6 times a day for 4 weeks.…”

Section: Post-operative Management Of Dedmentioning

confidence: 99%

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Cataract surgery and dry eye disease: A review

Naderi

Gormley

O’Brart

2020

European Journal of Ophthalmology

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Aim To review published literature concerning cataract surgery and dry eye disease (DED). Methods A search was undertaken using the following: PubMed (all years), Web of Science (all years), Ovid MEDLINE(R) (1946 to 12 December 2019), Ovid MEDLINE(R) Daily Update 10 December 2019, MEDLINE and MEDLINE non-indexed items, Embase (1974–2019, week 49), Ovid MEDLINE (R) and Epub Ahead of Print, In-Process and Other Non-Indexed Citations and Daily (1946 to 12 December 2019), CENTRAL (including Cochrane Eyes and Vision Trials Register; Cochrane Library: Issue 12 of 12 December 2019), metaRegister of Controlled Trials (mRCT) ( www.controlled-trials.com ), ClinicalTrials.gov ( www.clinicaltrial.gov ) and WHO International Clinical Trials Registry Platform ( www.who.int/ictrp/search/en ). Search terms included ‘cataract surgery’, ‘phacoemulsification’ and ‘cataract extraction’, combined with ‘dry eyes’ and ‘ocular surface’. Relevant in-article references not returned in our searches were also considered. Results Publications identified included systematic reviews, meta-analysis, randomized controlled trials, cohort studies, case series and laboratory-based studies. Published data highlighting the burden of DED both prior and following cataract surgery were reviewed as well as studies highlighting the effects of cataract surgery on the ocular surface, intra-operative measures to reduce deleterious effects on the ocular surface and current evidence on the management options of post-operative DED. Conclusions DED is common and can be exacerbated by cataract surgery. Ophthalmologists need to assess for pre-existing DED and instigate treatment before surgery; be aware of reduced accuracy of measurements for surgical planning in the presence of DED; limit intra-operative surgical factors damaging to the ocular surface; and consider management to reduce DED post-operatively.

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Section: Considerations Of the Management Of Cataract Surgery Associamentioning

confidence: 99%

Section: Post-operative Management Of Dedmentioning

confidence: 99%

Cataract surgery and dry eye disease: A review

Naderi

Gormley

O’Brart

2020

European Journal of Ophthalmology

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“…The decreased viscosity of tears in patients with qualitative dry eye [129] certainly may contribute to increased friction at the surface, and augmented attrition. Attrition would also be enhanced if the main cause of dry eye were the instability of the tear film, as suggested earlier [130]. Enhanced mechanical forces on an anatomically weakened epithelium will increase the cell stress and the secondary inflammation.…”

Section: Reducing the Impact Of Attrition: Dry Eye Therapymentioning

confidence: 79%

Impact of Attrition, Intercellular Shear in Dry Eye Disease: When Cells are Challenged and Neurons are Triggered

Setten

2020

IJMS

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The mechanical component in the pathophysiology of dry eye disease (DED) deserves attention as an important factor. The lubrication deficit induced impaired mechano-transduction of lid pressure to the ocular surfaces may lead to the dysregulation of homeostasis in the epithelium, with sensations of pain and secondary inflammation. Ocular pain is possibly the first sign of attrition and may occur in the absence of visible epithelial damage. Attrition is a process which involves the constant or repeated challenge of ocular surface tissues by mechanical shear forces; it is enhanced by the thinning of corneal epithelium in severe DED. As a highly dynamic process leading to pain and neurogenic inflammation, the identification of the impact of attrition and its potential pathogenic role could add a new perspective to the current more tear film-oriented models of ocular surface disease. Treatment of DED addressing lubrication deficiencies and inflammation should also consider the decrease of attrition in order to stimulate epithelial recovery and neural regeneration. The importance of hyaluronic acid, its molecular characteristics, the extracellular matrix and autoregulative mechanisms in this process is outlined. The identification of the attrition and recognition of its impact in dry eye pathophysiology could contribute to a better understanding of the disease and optimized treatment regimens.

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“…It was previously reported that cyclosporine accounted for 99% of the total expenditure for DED drugs (Seitzman and Lietman, 2018); however, we found that it is rarely used in China. Asian countries have a different view of DED etiology from that of the United States, recognizing tear instability rather than inflammation as the main cause for DED (Watanabe, 2018). Uncertain efficacy, side effects, and high cost also limit the use of these drugs (de Paiva et al, 2019;White et al, 2019;White et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…However, many treatments are poorly supported by evidence-based practices (Jones et al, 2017), and the efficacy of some (e.g., cyclosporine) is debated (Seitzman and Lietman, 2018). Pharmacotherapeutic approaches also vary by country because of differences in the understanding of DED etiology (Waduthantri et al, 2012;Watanabe, 2018). Ocular lubricant formulations such as sodium hyaluronate drops are favored by those who attribute DED to insufficient tear production (Watanabe, 2018).…”

Section: Introductionmentioning

confidence: 99%

Trends in Topical Prescriptional Therapy for Old Patients With Dry Eye Disease in Six Major Areas of China: 2013–2019

Zhu

et al. 2021

Front. Pharmacol.

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The prevalence of dry eye disease (DED) in old patients are high, corresponding to a substantial economic burden. In this cross-sectional study, we analyzed the trends in the topical prescriptional treatment of old patients with DED in six major areas of China. Information on topical drug prescriptions for DED patients aged above 60 years was extracted from the Hospital Prescription Analysis Cooperative Program of China database. Trends in yearly prescriptions and cost were analyzed. The data were further stratified by patient age and sex, drug class, and specific drug. A total of 130,734 prescriptions from 52 hospitals located in six major areas of China were analyzed. The number of prescripptions per year for patients with DED increased from 13,308 in 2013 to 22,074 in 2019, with a corresponding increase in cost of all topical drugs from 1,490,014 Chinese Yuan (CNY) to 2,618,206 CNY. Drugs for the treatment of DED accounted for the largest proportion of the total cost in each year. Ocular lubricants were the main pharmacotherapy agent. Sodium hyaluronate use increased over time, and the drug was used by 65.9% of patients by the end of the study. Pranoprofen was the second most frequently used drug. The most frequently used drugs for co-incident disease were antimicrobials. Treatment patterns for DED haven’t changed, and the most frequently used drug combination was sodium hyaluronate and pranoprofen. In summary, prescription for old patients with DED and the cost of treatment are increasing. Ocular lubricants are the main treatment option, while sodium hyaluronate is the most frequently used drug. The observed trends can lead to more efficient allocation of health care resources in China.

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Medical Treatment for Dry Eye in Japan

Cited by 16 publications

References 60 publications

Cataract surgery and dry eye disease: A review

Cataract surgery and dry eye disease: A review

Impact of Attrition, Intercellular Shear in Dry Eye Disease: When Cells are Challenged and Neurons are Triggered

Trends in Topical Prescriptional Therapy for Old Patients With Dry Eye Disease in Six Major Areas of China: 2013–2019

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