Medical Treatment of Ankylosing Spondylitis

Moon, Kyoung Ho; Kim, Young Tae

doi:10.5371/hp.2014.26.3.129

Cited by 26 publications

(28 citation statements)

References 23 publications

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“…Severe kyphotic deformity of dorsal spine can produce pain and inability to stand straight. This can be managed by an extension osteotomy like Watson Jones osteotomy [16][17][18].…”

Section: Treatmentmentioning

confidence: 99%

Ankylosing Spondylitis and Other Seronegative Arthritis

Zacharia¹,

Roy²

2020

Connective Tissue Disease - Current State of the Art

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Spondyloarthropathies are a group of disorders having some common features. They are characterised by inflammation of the attachment of tendons known as enthesitis. They are common in males. There is a familial occurrence. There is an association with HLA-B 27. Rheumatoid factor will be negative. Axial skeleton involvement in the form of sacroiliitis or spondylitis is common. The common conditions include ankylosing spondylitis, Reiter's disease, psoriatic arthritis, enteropathic arthritis and reactive arthritis. In this chapter we are going to describe the clinical features, evaluation and management of common spondyloarthropathies.

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“…Severe kyphotic deformity of dorsal spine can produce pain and inability to stand straight. This can be managed by an extension osteotomy like Watson Jones osteotomy [16][17][18].…”

Section: Treatmentmentioning

confidence: 99%

Ankylosing Spondylitis and Other Seronegative Arthritis

Zacharia¹,

Roy²

2020

Connective Tissue Disease - Current State of the Art

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“…There is presently no cure for AS, therefore the goal of treatment is to improve the health-related quality of life by reducing pain, improving physical function, and delaying structural damage (15).…”

mentioning

confidence: 99%

Long-Term Effectiveness and Safety of Infliximab and Golimumab in Ankylosing Spondylitis Patients from a Canadian Prospective Observational Registry

Rahman

Starr

Haaland

et al. 2020

Preprint

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Background: The objectives of this study were to describe the profile of ankylosing spondylitis (AS) patients treated with either infliximab (IFX) or subcutaneous golimumab (GLM) treatment in Canadian routine care setting along with assessing long-term effectiveness and safety. Methods: AS patients who were eligible for treatment with IFX or subcutaneous GLM as per their respective Canadian product monographs were enrolled into the BioTRAC registry from 2005-2017. The study visits occurred at baseline and every 6 months thereafter. Effectiveness was assessed by changes in clinical outcomes and acute phase reactants. Safety was evaluated by assessing the incidence of adverse events (AEs) and drug survival rates. Results: A total of 389 IFX- and 421 GLM-treated patients were enrolled. A significant decrease in disease duration at baseline was observed in the IFX cohort, from a median of 8.0 in 2005-2008 to 1.0 years in 2009-2015 (p<0.001). A reduction in baseline BASFI score (p=0.011) and proportion of patients in ASDAS very high disease activity (p=0.004) was also observed over time. Meanwhile, in the GLM cohort, most disease parameters remained similar from 2010-2017.Treatment with both agents significantly improved all disease parameters over time with similar efficacy between the two agents. The incidence of AEs and SAEs were 136 and 131 events/100 PYs and 10.5 and 8.45 events/100 PYs for IFX- and GLM-treated patients, respectively. Conclusion: Both IFX and GLM treatment in AS significantly reduced disease activity in most outcome measures in a similar fashion and were well tolerated in Canadian routine care. Trial Registration: NCT00741793

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“…встречается у лиц афро-карибского происхождения [1,17,26]. По разным данным анкилозирующий спондилит у мужчин бывает в 3-9 раз чаще, чем у женщин [1,17], наиболее уязвимыми у мужчин являются позвоночник и таз, в то время как у женщин чаще поражаются колени, запястья, плечи и бедра [1,17,26]. Провоцирующими факторами заболевания являются: воспалительные инфекции мочеполовой системы, стрептококки, переломы тазовых костей, нарушения функции эндокринной системы, переохлаждение, снижение иммунитета, генетическая предрасположенность, перенесенные вирусные, бактериальные и передающиеся половым путем инфекции.…”

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Использование Мануальной Терапии В Сочетании С Ударно-Волновой Терапией У Пациентов С Анкилозирующим Спондилитом

Франк¹,

M²,

Франк³

2019

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Ankylosing spondylitis is a chronic systemic disease of the connective tissue which affects primarily joints and ligaments of the spine, peripheral joints and internal organs, causing progressive development of limited spinal mobility due to ankylosing of epiphyseal joints, formation of syndesmosis and calcification of vertebral ligaments. There are currently no methods that can completely cure or stop the progression of ankylosing spondylitis, however, manual therapy combined with shock- wave therapy is able to quickly, non-invasively, effectively, economically, safely and without side effects support patients, improving their quality of life, prolonging the duration of the remissions, reducing the frequency of relapses, significantly delaying the development of structural damage and the progression of bone ankylosis. This study discusses the effect of manual therapy combined with shock wave therapy on ankylosing spondylitis resistant to other treatments.

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Medical Treatment of Ankylosing Spondylitis

Cited by 26 publications

References 23 publications

Ankylosing Spondylitis and Other Seronegative Arthritis

Ankylosing Spondylitis and Other Seronegative Arthritis

Long-Term Effectiveness and Safety of Infliximab and Golimumab in Ankylosing Spondylitis Patients from a Canadian Prospective Observational Registry

Использование Мануальной Терапии В Сочетании С Ударно-Волновой Терапией У Пациентов С Анкилозирующим Спондилитом

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