Medical Treatment of Antral Gastrin Cell Hyperfunction: Role of Nonantisecretory Therapy

Fave, Gianfranco Delle; Annibale, Bruno; Puoti, M.; Giordano, Elena; Corleto, Vito D.; Magistris, Laura de; Torsoli, A

doi:10.1159/000200334

Cited by 10 publications

(7 citation statements)

References 11 publications

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“…Basal acid output and pentagastrin acid output (6 μg/kg subcutaneously of Peptavlon; Zeneca, England) were determined in all patients, as previously described 15 . The reference values for gastric acid secretion at our laboratory are the following: basal acid output, median 4.1 meq/h (range 1.3–10 meq/h); pentagastrin acid output, median 31.1 meq/h (range 13–44.4 meq/h) 16 …”

Section: Methodsmentioning

confidence: 99%

“…15 The reference values for gastric acid secretion at our laboratory are the following: basal acid output, median 4.1 meq/h (range 1.3± 10 meq/h); pentagastrin acid output, median 31.1 meq/h (range 13±44.4 meq/h). 16 Gastrin assay. Plasma gastrin levels were determined by radioimmunoassay using antiserum 4562 (kindly supplied by Professor J. F. Rehfeld, Copenhagen, Denmark), as previously described.…”

Section: Methodsmentioning

confidence: 99%

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Occurrence and relapse of bleeding from duodenal ulcer: respective roles of acid secretion and Helicobacter pylori infection

Capurso¹,

Annibale²,

Osborn³

et al. 2001

Aliment Pharmacol Ther

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BACKGROUNDHelicobacter pylori infection and gastric acid hypersecretion together with NSAID consumption, are the main factors involved in gastroduodenal injury and bleeding. 1 Peptic ulcer is the most common cause of non-variceal upper gastrointestinal bleeding, accounting for 50±60% of cases. Bleeding episodes are frequent in duodenal ulcer patients, with a prevalence of 15±20% and a mortality up to 7%. 2 Patients who have bled once are considered to be at a higher risk of re-bleeding. Of duodenal ulcer patients, 95% have H. pylori infection of the gastroduodenal mucosa and its cure signi®cantly reduces the rate of both ulcer and bleeding recurrence in those patients with previous bleeding episodes. 3±6 Acid secretion has been found to be elevated in patients with bleeding from peptic ulcer. 7 Recent reports have shown that duodenal ulcer can also recur in the absence of H. pylori infection or NSAID consumption. 8, 9 SUMMARYBackground: Helicobacter pylori infection, gastric acid hypersecretion and NSAID consumption may cause peptic ulcer. Aim: To investigate the respective roles of H. pylori and acid secretion in bleeding duodenal ulcer. Patients and methods: A total of 99 duodenal ulcer patients were referred for evaluation of acid secretion: seven with Zollinger±Ellison Syndrome; 14 with hypersecretory duodenal ulcer, de®ned by the coexistence of elevated basal acid output and pentagastrin acid output; and 78 duodenal ulcer patients with normal acid output. All non-Zollinger±Ellison Syndrome patients were H. pylori-positive and cured of infection. All patients were followed-up for a 36-month period, to assess the occurrence of bleeding episodes. Results: Twenty-nine patients had at least one bleeding episode in the 4 years before the study. Bleeding was more frequent in males and in patients on NSAIDs. The

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Occurrence and relapse of bleeding from duodenal ulcer: respective roles of acid secretion and Helicobacter pylori infection

Capurso¹,

Annibale²,

Osborn³

et al. 2001

Aliment Pharmacol Ther

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“…bolus of 2 U/kg secretin). 23,24 None of them showed MEN-1 ( Antral gastrin cell hyperfunction. Six patients (®ve men, one woman, age range 24±54 years, median 35.5 years) in whom the diagnosis was de®ned by coexistence of basal and meal-stimulated gastrin levels exceeding the normal range, a negative secretin test, and an increased basal and/or peak acid output (BAO and PAO, respectively), as previously described (Table 1).…”

Section: Patientsmentioning

confidence: 99%

“…The reference values from our laboratory for gastric acid secretion are as follows: BAO, median 4.1 mmol/h (range 1.3±11.2); PAO, median 31.1 mmol/h (range 13±44.4); BAO/PAO < 0.3. 24 Gastrin assay. Plasma gastrin levels were determined by radioimmunoassay using antiserum 4562 (kindly supplied by Prof. J. F. Rehfeld, Copenhagen, Denmark), as previously described.…”

Section: Study Protocolmentioning

confidence: 99%

Relationship between fundic endocrine cells and gastric acid secretion in hypersecretory duodenal ulcer diseases

Annibale

Aprile

Ferraro

et al. 1998

Aliment Pharmacol Ther

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“…However, the mice gastrointestinal physiology differs considerably from that of human which is much more similar to that of swine (Pond and Houpt, 1978; Tumbleson and Schook, 1996; Kuzmuk and Schook, 2011). In view of pathological disorders such as antral G-cell hyperfunction (AGCH; Delle Fave et al, 1990; Kwan and Tytgat, 1995) it is important to evaluate the most appropriate model organism for studying human gastro-physiological processes. Therefore, comparative studies were performed to elucidate the distribution and molecular phenotype of G-cells and D-cells in the antral mucosa of men, swine, and mouse.…”

Section: Introductionmentioning

confidence: 99%

Receptors Responsive to Protein Breakdown Products in G-Cells and D-Cells of Mouse, Swine and Human

Haid¹,

Jordan-Biegger²,

Widmayer³

et al. 2012

Front. Physio.

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Monitoring the luminal content in the stomach is of vital importance for adjusting the gastric activities, including the release of gastric hormones such as gastrin. Our previous studies have shown that in mice the gastrin-secreting G-cells express receptor types which are responsive to amino acids. Since the pig is considered as more suitable model for studying gastro-physiological aspects relevant for men, in this study we have analyzed the distribution of G-cells and D-cells in the gastric antrum of men, swine, and mouse and the expression of receptor types which may render these cells responsiveness to protein breakdown products. The results indicate that the number of G-cells per antral invagination was significantly higher in swine and human compared to mice and also the distribution pattern of G-cells differed between the species. The molecular phenotyping revealed that the receptors GPRC6A and CaSR were also expressed in G-cells and in a subpopulation of D-cells from swine and men. As an additional receptor type, the peptone-receptor GPR92, was found to be expressed in G-cells and a subpopulation of D-cells; this receptor type may be particular suitable for sensing protein breakdown products and thus be a key element to adjust the activity of G-cells and D-cells according to the progress of the digestive processes in the stomach. In search for elements of an intracellular signaling cascade it was found that G-cells express the G-protein subunit Gαq as well as the phospholipase C subtype PLCβ3; in contrast, D-cells expressed the subtype PLCβ2 and neither Gαq. These results indicate that there are significant species differences concerning the number and distribution pattern, but not concerning the molecular phenotype of the gastric endocrine cells. However, G-cells and D-cells significantly differ from each other regarding the repertoire of receptors and signaling elements.

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Medical Treatment of Antral Gastrin Cell Hyperfunction: Role of Nonantisecretory Therapy

Cited by 10 publications

References 11 publications

Occurrence and relapse of bleeding from duodenal ulcer: respective roles of acid secretion and Helicobacter pylori infection

Occurrence and relapse of bleeding from duodenal ulcer: respective roles of acid secretion and Helicobacter pylori infection

Relationship between fundic endocrine cells and gastric acid secretion in hypersecretory duodenal ulcer diseases

Receptors Responsive to Protein Breakdown Products in G-Cells and D-Cells of Mouse, Swine and Human

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