Medical Treatment of Gastroesophageal Reflux Disease

Kroch, Daniel; Madanick, Ryan D.

doi:10.1007/s00268-017-3954-2

Cited by 19 publications

(8 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, in practice, the combination of magaldrate and alginate at bedtime may be useful for many patients with nonacid or mixed reflux according to MII‐pH. H 2 ‐receptor antagonists are second‐line treatment regarding the short duration of action (4‐8 hours) of these drugs 150 . In case of acid reflux, the prescription of twice‐daily PPIs could be associated with better symptom improvement than a once‐daily PPI prescription 151 …”

Section: Discussionmentioning

confidence: 99%

Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

Lechien¹,

Akst

Hamdan

et al. 2019

Otolaryngol.--head neck surg.

283

401

View full text Add to dashboard Cite

Objective To review the current literature about the epidemiology, clinical presentation, diagnosis, and treatment of laryngopharyngeal reflux (LPR). Data Sources PubMed, Cochrane Library, and Scopus. Methods A comprehensive review of the literature on LPR epidemiology, clinical presentation, diagnosis, and treatment was conducted. Using the PRISMA statement, 3 authors selected relevant publications to provide a critical analysis of the literature. Conclusions The important heterogeneity across studies in LPR diagnosis continues to make it difficult to summarize a single body of thought. Controversies persist concerning epidemiology, clinical presentation, diagnosis, and treatment. No recent epidemiologic study exists regarding prevalence and incidence with the use of objective diagnostic tools. There is no survey that evaluates the prevalence of symptoms and signs on a large number of patients with confirmed LPR. Regarding diagnosis, an increasing number of authors used multichannel intraluminal impedance–pH monitoring, although there is no consensus regarding standardization of the diagnostic criteria. The efficiency of proton pump inhibitor (PPI) therapy remains poorly demonstrated and misevaluated by incomplete clinical tools that do not take into consideration many symptoms and extralaryngeal findings. Despite the recent advances in knowledge about nonacid LPR, treatment protocols based on PPIs do not seem to have evolved. Implications for Practice The development of multichannel intraluminal impedance–pH monitoring and pepsin and bile salt detection should be considered for the establishment of a multiparameter diagnostic approach. LPR treatment should evolve to a more personalized regimen, including diet, PPIs, alginate, and magaldrate according to individual patient characteristics. Multicenter international studies with a standardized protocol could improve scientific knowledge about LPR.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

Lechien¹,

Akst

Hamdan

et al. 2019

Otolaryngol.--head neck surg.

283

401

View full text Add to dashboard Cite

show abstract

“…A positive correlation was found between high RSI scores and excessive caffeine intake (r s = 0.322 [fair]; p = 0.043), indicating that participants with excessive caffeine intake had higher RSI scores. Although some studies have shown that caffeine intake may be related to reflux (Pehl et al, 1997), more recent literature has found this data weak (Katz et al, 2013;Kroch & Madanick, 2017). The relationship between caffeine and the RSI specifically has not been explored to the authors' knowledge.…”

Section: Comparisons With Other Studiesmentioning

confidence: 92%

Reflux symptoms and vocal characteristics in adults with non-organic voice disorders

Groenewald

Toit

Graham

et al. 2022

SAJCD

View full text Add to dashboard Cite

Background: Laryngopharyngeal reflux (LPR) is prevalent and can lead to voice disorders, but its diagnosis is difficult, because of limited correlations between clinical symptoms and organic pathology. Various tools and methods have been explored to aid a diagnosis of LPR.Objective: To investigate associations between reflux symptoms, acoustic-, perceptual-, and physical vocal characteristics, glottal function index (GFI), and vocal handicap index (VHI) in adults with non-organic voice disorders.Methods: Data of 51 adults with non-organic voice disorders were collected, using a retrospective cohort explorative research design, at a private ear, nose and throat specialist practice in Gauteng, South Africa. Quantitative outcomes were compared between reflux symptom index (RSI), acoustic characteristics (jitter, shimmer and fundamental frequency [F0]), maximum phonation time, perceptual- (GRBASI) and physical vocal characteristics, GFI and VHI.Results: The RSI showed positive fair correlations against GFI, VHIP and caffeine intake, indicating an increase in reflux symptoms with higher scores on the various measures. Moderate correlations were also found between GFI and VHIP, grade of hoarseness and jitter, strain and VHIP, strain and VHI total (VHIT) and between Asthenia and jitter. Very strong correlations were found within the various subsections of the VHI as well as between jitter and shimmer and between F0-male and physical symptoms of the VHI (VHIP).Conclusion: Results indicated associations between reflux symptoms, vocal characteristics, the GFI and the VHI. Based on the correlations found these tools used in conjunction could improve clinical diagnosis of LPR. Implications of these findings are promising, but further research is recommended.Contribution: This study contributes to the body of knowledge to support the accurate clinical diagnosis of LPR using subjective measures to determine LPR symptoms, as well as acoustic analysis.

show abstract

“…Conservative measures, as already mentioned, include weight loss, if the patient is obese and overweight, the elevation of the bed head, avoiding late-night meals, and reducing the consumption of alcohol, fat, caffeine, and chocolate intake [ 3 , 5 ]. Medical treatment is commonly achieved through antacids, H2 receptor antagonists (H2RAs), and proton pump inhibitors for heartburn and acid regurgitation [ 28 ]. PPIs work by inhibiting the acid secretion from parietal cells.…”

Section: Reviewmentioning

confidence: 99%

Role of Non-pharmacological Interventions and Weight Loss in the Management of Gastroesophageal Reflux Disease in Obese Individuals: A Systematic Review

Mukhtar¹,

Alzubaidee²,

Dwarampudi³

et al. 2022

Cureus

View full text Add to dashboard Cite

With the increasing prevalence of obesity, the worldwide risk of gastroesophageal reflux disease (GERD) has also increased. Abdominal obesity increases intragastric pressure, disturbing the integrity of the gastroesophageal junction, thus facilitating reflux. Other than obesity, some lifestyle factors also cause GERD, including smoking, consumption of alcohol and caffeine, late-night meals, and high fat intake. This review study aimed to assess the impact of weight loss and lifestyle modifications on GERD. In this systematic review, the databases used were PubMed, PubMed Central (PMC), Science Direct, and Google Scholar. Boolean system and Medical Subject Headings (MeSH) strategy were used to form suitable keywords. Patients from the pediatric and geriatric populations were excluded from the study and quality assessment was done using different assessment tools. A positive association between obesity and GERD was found. It was also found that the long-term use of proton pump inhibitors (PPIs) causes complications, so lifestyle interventions should be used more than PPIs for treating GERD, especially in obese patients. We concluded that weight loss could lead to the resolution of gastroesophageal reflux disease, and therefore, conservative measures, including dietary modifications such as reducing the consumption of alcohol, caffeine, and chocolate, behavioral changes such as smoking cessation and elevation of the head of the bed, and weight loss, should be used as first-line management for GERD. Although awareness has increased regarding the adverse effects of proton pump inhibitors, future studies are required to assess these negative effects.

show abstract

Medical Treatment of Gastroesophageal Reflux Disease

Cited by 19 publications

References 84 publications

Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

Reflux symptoms and vocal characteristics in adults with non-organic voice disorders

Role of Non-pharmacological Interventions and Weight Loss in the Management of Gastroesophageal Reflux Disease in Obese Individuals: A Systematic Review

Contact Info

Product

Resources

About