Medical Treatment of Meniere's Disease: A Review of Literature

Claes, J.; Heyning, P.H. Van de

doi:10.3109/00016489709124019

Cited by 46 publications

(13 citation statements)

References 35 publications

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“…Numerous reports have stated that control of vertigo can be obtained in 60 -80% of patients at earlier stages (12). However, effective therapy seems to constitute a dif cult clinical problem.…”

Section: Discussionmentioning

confidence: 99%

Control of Symptoms in Patients with Me´nie`re's Disease Using Middle Ear Pressure Applications: Two Years Follow-up

Densert¹,

Sass²

2001

Acta Oto-Laryngologica

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The effects of middle ear pressure pulses were studied in 37 patients with a diagnosis of definite Meniere's disease and active vestibular symptoms, 31 of whom had failed to respond to medical treatment including diuretics prior to pressure treatment. The number of vertigo spells during the 6 months prior to treatment and for 6, 18 and 24 months after the start of treatment were evaluated. The functionality level scores were three or worse according to the American Academy of Otolaryngology--Head and Neck Surgery (AAO-HNS) criteria. The results of the study were as follows: 19 patients experienced freedom from vertigo spells; 15 patients reported a significant decrease in the frequency of vertigo spells; and 3 patients did not respond to pressure treatment and were subjected to gentamicin injections, I of whom consequently became deaf in the affected ear. No patient became worse in connection with pressure treatment. With the exception of the three patients who did not respond to pressure treatment, all patients reported an improvement in functionality of at least two levels according to the AAO-HNS functionality scale. No side effects or adverse events were observed during the 2 years of pressure treatment. Overall, the results indicate that pressure treatment provides efficient control of symptoms in patients with intractable forms of Ménière's disease without producing any adverse effects on the inner ear.

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Section: Discussionmentioning

confidence: 99%

Control of Symptoms in Patients with Me´nie`re's Disease Using Middle Ear Pressure Applications: Two Years Follow-up

Densert¹,

Sass²

2001

Acta Oto-Laryngologica

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“…Betahistine (H1 receptor agonist, H3 receptor antagonist) and Arlevert ® (fixed combination of cinnarizine, a calcium channel blocker, and dimenhydrinate, a H1-receptor antagonist) are drugs often used as mainstay therapy for vertigo control in Meniere’s disease and can reduce number and intensity of vertigo episodes [130,131]. If numerous recurrent vertigo attacks occur, transtympanic gentamicin application is used to destroy vestibular hair cells, as gentamicin is 4 times more vestibulotoxic than cochleotoxic.…”

Section: Pharmaceutical Therapymentioning

confidence: 99%

Inner ear symptoms and disease: Pathophysiological understanding and therapeutic options

Ciuman

2013

Med Sci Monit

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In recent years, huge advances have taken place in understanding of inner ear pathophysiology causing sensorineural hearing loss, tinnitus, and vertigo. Advances in understanding comprise biochemical and physiological research of stimulus perception and conduction, inner ear homeostasis, and hereditary diseases with underlying genetics. This review describes and tabulates the various causes of inner ear disease and defines inner ear and non-inner ear causes of hearing loss, tinnitus, and vertigo. The aim of this review was to comprehensively breakdown this field of otorhinolaryngology for specialists and non-specialists and to discuss current therapeutic options in distinct diseases and promising research for future therapies, especially pharmaceutic, genetic, or stem cell therapy.

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“…In Europe, betahistine is often used, mainly on the basis of a study by Meyer [34] and more recent meta-analyses [35, 36]. Betahistine is an H 1 -agonist and H 3 -antagonist.…”

Section: Peripheral Vestibular Disordersmentioning

confidence: 99%

Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus

Strupp¹,

et al. 2011

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We review current pharmacological treatments for peripheral and central vestibular disorders, and ocular motor disorders that impair vision, especially pathological nystagmus. The prerequisites for successful pharmacotherapy of vertigo, dizziness, and abnormal eye movements are the “4 D’s”: correct diagnosis, correct drug, appropriate dosage, and sufficient duration. There are seven groups of drugs (the “7 A’s”) that can be used: antiemetics; anti-inflammatory, anti-Ménière’s, and anti-migrainous medications; anti-depressants, anti-convulsants, and aminopyridines. A recovery from acute vestibular neuritis can be promoted by treatment with oral corticosteroids. Betahistine may reduce the frequency of attacks of Ménière’s disease. The aminopyridines constitute a novel treatment approach for downbeat and upbeat nystagmus, as well as episodic ataxia type 2 (EA 2); these drugs may restore normal “pacemaker” activity to the Purkinje cells that govern vestibular and cerebellar nuclei. A limited number of trials indicate that baclofen improves periodic alternating nystagmus, and that gabapentin and memantine improve acquired pendular and infantile (congenital) nystagmus. Preliminary reports suggest suppression of square-wave saccadic intrusions by memantine, and ocular flutter by beta-blockers. Thus, although progress has been made in the treatment of vestibular neuritis, some forms of pathological nystagmus, and EA 2, controlled, masked trials are still needed to evaluate treatments for many vestibular and ocular motor disorders, including betahistine for Ménière’s disease, oxcarbazepine for vestibular paroxysmia, or metoprolol for vestibular migraine.

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Medical Treatment of Meniere's Disease: A Review of Literature

Cited by 46 publications

References 35 publications

Control of Symptoms in Patients with Me´nie`re's Disease Using Middle Ear Pressure Applications: Two Years Follow-up

Control of Symptoms in Patients with Me´nie`re's Disease Using Middle Ear Pressure Applications: Two Years Follow-up

Inner ear symptoms and disease: Pathophysiological understanding and therapeutic options

Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus

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