Medical Treatment of Metastatic Melanoma

Houghton, Alan N.; Meyers, Michael L.; Chapman, Paul B.

doi:10.1016/s0039-6109(05)70519-3

Cited by 18 publications

(10 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[2][3][4][5] For obvious reasons, recognition of skin metastasis from melanoma is of paramount importance because the therapeutic management and the implications for disease stage can be drastically different. 6 In the majority of patients, the histologic diagnosis of metastatic melanoma usually poses little problems. Occasionally, however, they can adopt unusual appearances that may introduce difficulties for diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Metastases of Malignant Melanoma: A Clinicopathologic Study of 192 Cases With Emphasis on the Morphologic Spectrum

Plaza

Torres‐Cabala²,

Evans

et al. 2010

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Metastatic melanoma represents one of the most common types of cutaneous metastases. In up to 5% of patients, metastatic melanoma can be the first manifestation of the disease. For the most part, the histologic diagnosis of metastatic melanoma poses little diagnostic difficulty; however, some metastases may adopt unusual or unfamiliar appearances mimicking other benign and malignant conditions. We present a study of 192 cases of cutaneous metastatic melanomas with special emphasis on their spectrum of morphologic features. The patients were 115 men and 77 women, 23-91 years of age (mean 57 years). Most tumors were located on the proximal legs, scalp, and arms and ranged from 0.8 to 3.0 cm. One hundred ten cases showed the classic morphologic appearance of melanoma (well-circumscribed epithelioid dermal/subcutaneous nodule), 82 cases showed unusual histologic appearances that mimicked other benign and malignant neoplasms. In 16 patients (8.3%), there was no evidence of primary melanoma and the cutaneous metastasis was the only manifestation of the disease. The histologic diagnosis of cutaneous metastatic melanoma can pose difficulties for diagnosis, especially in the face of an unknown primary neoplasm. Unusual features observed in this series included examples of cutaneous metastatic melanoma that closely simulated metastatic carcinoma, dermatofibroma, leiomyosarcoma, angiosarcoma, nevoid melanoma, halo nevus, blue nevi, and atypical fibroxanthoma. Several cases also showed rhabdoid, balloon cell, and alveolar features. Immunohistochemical stains plus careful clinical history helped to establish the correct diagnosis. Our series illustrates that the differential diagnosis of cutaneous metastatic melanoma can be broad and difficult. To the best of our knowledge, this is the largest series of cutaneous metastatic melanomas reported in the literature.

show abstract

Section: Introductionmentioning

confidence: 99%

Cutaneous Metastases of Malignant Melanoma: A Clinicopathologic Study of 192 Cases With Emphasis on the Morphologic Spectrum

Plaza

Torres‐Cabala²,

Evans

et al. 2010

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…One of the promising novel therapies is the application of stem cell transplantation (SCT). * Clinical and experimental data indicate that allogeneic SCT not only reconstitutes the patient's hematopoietic system, but also mediates a powerful curative effect in patients transplanted for hematological malignancies or solid tumors (2)(3)(4)(5)(6)(7)(8). These alloimmune graft-versus-host reactions generally lack tumor specificity and are often accompanied by severe GVHD.…”

Section: Introductionmentioning

confidence: 99%

The Hematopoietic System–specific Minor Histocompatibility Antigen HA-1 Shows Aberrant Expression in Epithelial Cancer Cells

Klein

Wilke

Pool

et al. 2002

The Journal of Experimental Medicine

View full text Add to dashboard Cite

Allogeneic stem cell transplantation (SCT) can induce curative graft-versus-tumor reactions in patients with hematological malignancies and solid tumors. The graft-versus-tumor reaction after human histocompatibility leukocyte antigen (HLA)-identical SCT is mediated by alloimmune donor T cells specific for polymorphic minor histocompatibility antigens (mHags). Among these, the mHag HA-1 was found to be restricted to the hematopoietic system. Here, we report on the HA-1 ribonucleic acid expression by microdissected carcinoma tissues and by single disseminated tumor cells isolated from patients with various epithelial tumors. The HA-1 peptide is molecularly defined, as it forms an immunogenic peptide ligand with HLA-A2 on the cell membrane of carcinoma cell lines. HA-1–specific cytotoxic T cells lyse epithelial tumor cell lines in vitro, whereas normal epithelial cells are not recognized. Thus, HA-1–specific immunotherapy combined with HLA-identical allogeneic SCT may now be feasible for patients with HA-1+ carcinomas.

show abstract

“…If metastases are identified to be limited to the GI tract, aggressive surgical management offers the best chance for prolonged palliation and life. After surgical intervention referral to medical oncology is necessary for continual monitoring of advanced disease and initiation of chemotherapy, immunotherapy, radiotherapy, or repeat surgery if indicated 19 …”

Section: Discussionmentioning

confidence: 99%