with clinical remission? With the exception of overeating and extreme fat intake, it is desirable to minimize dietary restrictions during patients with remission.We recently demonstrated in multicenter prospective cohort study that advanced therapy as well as corticosteroids was effective as the first-line treatment in hospitalized patients [3,4], although the influence of dietary restriction was not investigated in our study. While recent guidelines indicated that corticosteroid is the first-line treatment for hospitalized patients with severe disease, we would like to emphasize that use of advanced therapy may be acceptable for patients with acute severe UC. Although there are many advanced therapies, these treatments should be selected according to the clinical background and severity of disease [3,4]. The effects of dietary therapy on hospitalized patients should be investigated by accumulating a large number of cases.