Medically supervised water-only fasting in the treatment of hypertension

Goldhamer, Alan; Lisle, Douglas J.; Parpia, Banoo; Anderson, Scott V.; Campbell, T. Colin

doi:10.1067/mmt.2001.115263

Cited by 59 publications

(46 citation statements)

References 16 publications

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“…BP remained significantly lower compared to baseline even after subjects resumed the normal diet for an average of 6 days (Goldhamer et al, 2002). A small pilot study of patients with hypertension (140 mm and above systolic BP) also showed that 10–11 days of fasting caused a 37–60 mm decrease in systolic BP (Goldhamer et al, 2001). These preliminary studies are promising but underscore the need for larger controlled and randomized clinical studies that focus on periodic fasting strategies that are feasible for a larger portion of the population.…”

Section: Fasting Aging and Disease In Humansmentioning

confidence: 99%

Fasting: Molecular Mechanisms and Clinical Applications

2014

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Fasting has been practiced for millennia, but only recently studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism and bolster cellular protection. In lower eukaryotes, chronic fasting extends longevity in part by reprogramming metabolic and stress resistance pathways. In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma and rheumatoid arthritis. Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions.

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Section: Fasting Aging and Disease In Humansmentioning

confidence: 99%

Fasting: Molecular Mechanisms and Clinical Applications

2014

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“…PB remained significantly lower after subjects had returned to their normal diet for 6 days. In another study, 10–11 days of fasting decreased systolic blood pressure of hypertensive patients by 37–60 mm, but this study did not follow patients after they returned to their normal diet (Goldhamer et al, 2001). In summary, both IF and PF have potential applications for inflammatory and cardiovascular diseases, but additional, larger and randomized studies are needed before these strategies can be integrated in the standard of care by physicians.…”

Section: If and Pf In The Prevention And Treatment Of Chronic Diseasementioning

confidence: 99%

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

2016

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Summary Feeding in most animals is confined to a defined period, leaving short periods of fasting that coincide with sleep. Fasting enables organisms to enter alternative metabolic phases, which rely less on glucose and more on ketone body-like carbon sources. Both intermittent and periodic fasting result in benefits ranging from prevention to the enhanced treatment of diseases. Similarly, time-restricted feeding (TRF), in which feeding time is restricted to certain hours of the day, allows the daily fasting period to last >12 h, thus imparting pleiotropic benefits in multiple organisms. Understanding the mechanistic link between nutrients and the fasting benefits is leading to the identification of fasting mimicking diets (FMDs) that achieve changes similar to those caused by fasting. Given the pleiotropic and sustained benefits of TRF and FMD, both basic science and translational research are warranted to develop fasting-associated interventions into effective and inexpensive treatments with the potential to improve healthspan.

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“…In a study on 68 patients with borderline hypertension undergoing 10-14 days of water-only fasting [98], the mean blood pressure reduction amounted to 20/7 mm Hg. In a further uncontrolled study [99], the same research group reported results of 10-11 days of medically supervised fasting in 174 consecutive inpatients with hypertension. Fasting led to an average blood pressure reduction of 37/13 mm Hg, and in patients with stage 3 hypertension to an average reduction of 60/17 mm Hg.…”

Section: Clinical Effects Of Fastingmentioning

confidence: 99%

Fasting Therapy for Treating and Preventing Disease - Current State of Evidence

Michalsen

2013

Complement Med Res

114

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Periods of deliberate fasting with restriction of solid food intake are practiced worldwide, mostly based on traditional, cultural or religious reasons. There is large empirical and observational evidence that medically supervised modified fasting (fasting cure, 200-500 kcal nutritional intake per day) with periods of 7-21 days is efficacious in the treatment of rheumatic diseases, chronic pain syndromes, hypertension, and metabolic syndrome. The beneficial effects of fasting followed by vegetarian diet in rheumatoid arthritis are confirmed by randomized controlled trials. Further beneficial effects of fasting are supported by observational data and abundant evidence from experimental research which found caloric restriction and intermittent fasting being associated with deceleration or prevention of most chronic degenerative and chronic inflammatory diseases. Intermittent fasting may also be useful as an accompanying treatment during chemotherapy of cancer. A further beneficial effect of fasting relates to improvements in sustainable lifestyle modification and adoption of a healthy diet, possibly mediated by fasting-induced mood enhancement. Various identified mechanisms of fasting point to its potential health-promoting effects, e.g., fasting-induced neuroendocrine activation and hormetic stress response, increased production of neurotrophic factors, reduced mitochondrial oxidative stress, general decrease of signals associated with aging, and promotion of autophagy. Fasting therapy might contribute to the prevention and treatment of chronic diseases and should be further evaluated in controlled clinical trials and observational studies.

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Medically supervised water-only fasting in the treatment of hypertension

Cited by 59 publications

References 16 publications

Fasting: Molecular Mechanisms and Clinical Applications

Fasting: Molecular Mechanisms and Clinical Applications

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

Fasting Therapy for Treating and Preventing Disease - Current State of Evidence

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