Medicament Release from Suppository Bases I: Physicochemical Characteristics and Bioavailability of Indomethacin in Rabbits

Vidras, Nicholas J.; Reid, Vincent E.; Bohidar, N. R.; Plakogiannis, Fotios M.

doi:10.1002/jps.2600710828

Cited by 29 publications

(7 citation statements)

References 19 publications

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“…The phenomenon continue until the suppository is completely dissolved. This finding is similar to that from the suppositories containing HP55-PEG mixture matrix bases as discussed in a previous paper (12).…”

Section: Release Of Im From Suppositories In Vitrosupporting

confidence: 92%

Preparation and in Vitro Evaluation of Sustained Release Suppositories of Indomethacine : İndometazi̇ni̇n Sürekli̇ Etki̇li̇ Suppozi̇tuvarlarinin Hazirlanmasi Ve İnvi̇tro Değerlendi̇ri̇lmesi̇

Tarimci¹,

Ermiş²

1998

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Section: Release Of Im From Suppositories In Vitrosupporting

confidence: 92%

Preparation and in Vitro Evaluation of Sustained Release Suppositories of Indomethacine : İndometazi̇ni̇n Sürekli̇ Etki̇li̇ Suppozi̇tuvarlarinin Hazirlanmasi Ve İnvi̇tro Değerlendi̇ri̇lmesi̇

Tarimci¹,

Ermiş²

1998

Ankara Universitesi Eczacilik Fakultesi Dergisi

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“…3,8,12)The release behavior of indomethacin from suppositories differed greatly among the three methods.One of the main reasons for this is the differences in the physical force affecting the suppository:in the JP XI paddle method the hydrodynamic flow affects the suppositories,while in Muranishi method the stirring steel rod must promote the disintegration of suppositories and in the dialysis tubing method the pressure of test fluid and the tension of the weighted tubing would enhance the spreading of melted suppositories along the dialysis tubing.These differences among the methods must contribute to the differences in the drug release behavior,although other factors including the membrane permeability of the drug should also be taken into consideration.…”

Section: Factors Affecting Drug Release In the Dialysis Tubing Methodsmentioning

confidence: 99%

Release rates of indomethacin from commercial witepsol suppositories and the bioavailabilities in rabbits and pigs.

Aoyagi

Kaniwa

Takeda

et al. 1988

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…In this study, the dialysis technique was used because the drug release will be in a condition similar to that of the rectum [31][32][33].…”

Section: In-vitro Release Of Kt From Different Suppository Formulatiomentioning

confidence: 99%

Preparation and evaluation of Ketotifen suppositories

Mohamed

Mahmoud

Mohamed

2020

Journal of advanced Biomedical and Pharmaceutical Sciences

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Ketotifen KT is one of antiallergic drugs, due to its first pass effect, the bioavailability of the drug is only 50 %. The objective of this study was to formulate and evaluate suppositories containing KT a n d / o r K T s o l i d d i s p e r s i o n. The in-vitro release of KT from suppositories was done using dialysis membrane method in phosphate buffer at pH 7.4. The release of KT from water soluble suppository bases was higher than that from fatty or emulsion suppositories bases. Among all PEGs bases (F4: PEG 6000: PG (20: 80)) showed a relatively higher release of KT. Formulations prepared with glycerin bases gave more or less identical release pattern; relatively formula (F17: Gelatin: Glycerin: Propylene glycol: Water) gave the highest release pattern. Formula (F20: Suppocire AM) exhibited the highest release rate among fatty bases. Within all emulsion bases (F23: W 15 : W 75 : Tween 20: Span 60: PEG 1500: Propylene glycol) showed highest release rate. KT solid dispersion led to a higher release rate of the drug from selected bases. A histological comparison between control group of rabbits (didn`t take suppository), another group took plain suppositories and group that received suppositories containing solid dispersion of KT was carried out. The tested plain and medicated bases didn't injure the rectal mucosa of rabbits. In conclusion the incorporation of solid dispersion in formula (F4) complied with the pharmacobeial limits for hardness, dissolution time, content uniformity and weight variation. Also it showed a relatively higher invitro release of KT and considered as safe and useful formulation for clinical use.

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Medicament Release from Suppository Bases I: Physicochemical Characteristics and Bioavailability of Indomethacin in Rabbits

Cited by 29 publications

References 19 publications

Preparation and in Vitro Evaluation of Sustained Release Suppositories of Indomethacine : İndometazi̇ni̇n Sürekli̇ Etki̇li̇ Suppozi̇tuvarlarinin Hazirlanmasi Ve İnvi̇tro Değerlendi̇ri̇lmesi̇

Preparation and in Vitro Evaluation of Sustained Release Suppositories of Indomethacine : İndometazi̇ni̇n Sürekli̇ Etki̇li̇ Suppozi̇tuvarlarinin Hazirlanmasi Ve İnvi̇tro Değerlendi̇ri̇lmesi̇

Release rates of indomethacin from commercial witepsol suppositories and the bioavailabilities in rabbits and pigs.

Preparation and evaluation of Ketotifen suppositories

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