Medicamentos causantes de hepatotoxicidad en el embarazo: revisión estructurada

P, Alejandra Cano; Amariles, Pedro

doi:10.22516/25007440.128

Cited by 2 publications

(1 citation statement)

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“…NVP's associated hepatotoxicity in the clinics (case reports, clinical trials and cohorts' studies) has been reviewed in detail elsewhere [63]. A structured review of the literature (2005-2015) also revealed that NVP causes hepatotoxicity in pregnant patients, manifested as elevation of transaminases, rash, hepatitis, pruritus, abdominal pain, eosinophilia, encephalopathy, and jaundice [64]. The link between NVP and more advanced stages of liver disease has also been assessed through studies with HCV-coinfected patients, obtaining somewhat contradictory results.…”

Section: Nevirapinementioning

confidence: 99%

NNRTI and Liver Damage: Evidence of Their Association and the Mechanisms Involved

Benedicto

Fuster-Martínez

Tosca

et al. 2021

Cells

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Due to the improved effectiveness and safety of combined antiretroviral therapy, human immunodeficiency virus (HIV) infection has become a manageable, chronic condition rather than a mortal disease. However, HIV patients are at increased risk of experiencing non-AIDS-defining illnesses, with liver-related injury standing out as one of the leading causes of death among these patients. In addition to more HIV-specific processes, such as antiretroviral drug-related toxicity and direct injury to the liver by the virus itself, its pathogenesis is related to conditions that are also common in the general population, such as alcoholic and non-alcoholic fatty liver disease, viral hepatitis, and ageing. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are essential components of combined anti-HIV treatment due to their unique antiviral activity, high specificity, and acceptable toxicity. While first-generation NNRTIs (nevirapine and efavirenz) have been related largely to liver toxicity, those belonging to the second generation (etravirine, rilpivirine and doravirine) seem to be generally safe for the liver. Indeed, there is preclinical evidence of rilpivirine being hepatoprotective in different models of liver injury, independently of the presence of HIV. The present study aims to review the mechanisms by which currently available anti-HIV drugs belonging to the NNRTI family may participate in the development of liver disease.

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Section: Nevirapinementioning

confidence: 99%