Medicamentos utilizados en pediatría extrahospitalaria: ¿disponemos de información suficiente?

Morales-Carpi, C.; Chover, N. Julve; Lobatón, Ramiro; Estañ, Luis; Rubio, E.; Lurbe, Empar; Morales‐Olivas, Francisco J.

doi:10.1157/13120040

Cited by 21 publications

(10 citation statements)

References 40 publications

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“…Outros autores (9,10) ainda destacam que os medicamentos empregados em Pediatria muitas vezes não possuem ações comprovadas nesse público. Morales-Carpi et al (11) reforçam que, na maioria das vezes, os responsáveis pelas crianças possuem informações insuficientes e incongruentes sobre os medicamentos, mas, mesmo assim, adotam a automedicação em seus filhos.…”

Section: Introductionunclassified

Utilização de medicamentos na Pediatria: a prática de automedicação em crianças por seus responsáveis

Beckhauser¹,

Souza²,

Valgas

et al. 2010

Rev. paul. pediatr.

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OBJETIVO: Conhecer a automedicação em crianças moradoras de uma cidade da região Sul do Brasil. MÉTODOS: Estudo transversal com amostra selecionada por sorteio, inicialmente identificando as equipes de Estratégia Saúde da Família e, posteriormente, as residências que seriam visitadas. Foi adotado, para a entrevista com o responsável pelas crianças, um questionário para avaliar o perfil da criança, da família e da prática da automedicação. Para apresentação dos dados, adotou-se a estatística descritiva e o teste do qui-quadrado (p<0,05). RESULTADOS: Entrevistaram-se os responsáveis pelas crianças em 83 domicílios. Foram coletadas informações de 121 crianças (seis meses a 14 anos). Dos entrevistados, 75% afirmaram já ter praticado a automedicação, sendo as mães responsáveis por 95% desses casos. Quanto às situações que motivaram a automedicação, praticidade (88%), febre (58%) e dor (12%) foram as mais relatadas. O paracetamol (45%) e a dipirona (15%) foram os fármacos mais utilizados. A análise estatística evidenciou associação entre a reutilização de antigas prescrições e a idade da criança inferior a sete anos, bem como entre a utilização de medicamentos sem prescrição de profissional habilitado e morar em domicílios com mais de quatro pessoas. CONCLUSÕES: A automedicação é uma prática frequente na população investigada, sendo geralmente mais comum em crianças de até sete anos e realizada principalmente pelas mães; esse fato sugere a necessidade de promover educação em saúde que vise à promoção do uso racional de medicamentos.

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Section: Introductionunclassified

Utilização de medicamentos na Pediatria: a prática de automedicação em crianças por seus responsáveis

Beckhauser¹,

Souza²,

Valgas

et al. 2010

Rev. paul. pediatr.

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“…A prospective study conducted by Martinez-mir et al noticed therapeutic group most commonly implicated was anti-infective drugs and vaccines which is similar to our findings. 15 Amoxicillin+clavulanic acid and ceftriaxone were widely prescribed antimicrobials in our hospital setup and the reason for more number of ADRs with these drugs. Pediatric patients are exposed to many vaccines like measeles vaccine, polio vaccine and pentavalent vaccines.…”

Section: Discussionmentioning

confidence: 90%

“…13 A study conducted by Choonara et al and Martinez-Mir et al found 5.60% and 11.52% incidence of ADRs respectively. 14,15 In adult the incidence of ADR is 4.4% which shows that in the pediatric population the incidence is more as compared to adult. In our study, a little more preponderance to male (57%) for the development of adverse drug reactions was seen as compared to females (43%).…”

Section: Discussionmentioning

confidence: 99%

An intensive monitoring of adverse drug reactions in pediatric hospitalized patients of a tertiary care hospital

Patel

Makrani

Gandhi

et al. 2021

Int J Basic Clin Pharmacol

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Background: Children are at a higher risk of therapeutic failure due to major difference in pharmacokinetic, pharmacodynamics of drugs, off-label use and divergence of their illness from adult. The safety of drugs used in adult patients cannot be extrapolated to a pediatric age group. Hence, this study aimed to evaluate the incidence and overall pattern of adverse drug reactions in pediatric patients hospitalized in pediatric wards at a tertiary care hospital in India.Methods: Pediatric patients up to 12 years hospitalized in two randomly selected pediatric units were enrolled and followed up daily till discharge. Detailed information of patients and ADRs (adverse drug reactions) if any were recorded from case records. ADRs were assessed for incidence, onset, duration, management, outcome, causality, severity, preventability, seriousness and risk factors. Appropriateness of drug treatment in patients with ADRs was analyzed using Phadke’s criteria. Data was analyzed using student’s t test, ANOVA and Chi square test.Results: A total of 700 patients were enrolled (mean age 3.95±0.12 years). A total of 66 ADRs observed in 58 patients. Intravenous (70.4%) being most common route for ADRs. The incidence of ADRs was 8.28%. Majority of ADRs occurred within 1 day, commonly affected skin and appendages followed by (28.78%), GI (25.75%) ADRs were frequently associated with antimicrobials (69.38%) and vaccines and sera (12.24%). Majority of reactions were mild (56%%), non-serious (77.2%), not preventable (95.4%), recovered completely at discharge (83.33%) and had possible (77.2%) causal association with suspect drug. Age group 0-3 years and prescription of ≥5 drugs were risk factors for occurrence of ADRs. Semi rational drug therapy was observed in 65.5% patients.Conclusions: Clinicians should be vigilant regarding occurrence of ADRs in pediatrics especially during the first week of hospitalization. Risk factors like 0-3 years of age and multiple drugs should be taken into consideration during treatment of these patients to help minimize adverse drug reactions.

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“…635 (87%) NOM were found, occurred to infants (237; 38%) and children (117; 19%) and 318 (51%), referred as non-quantitative ineffectiveness. These results could be explained by the higher medicine use in pre-schoolers [42], lack of knowledge of medicines in those ages [43,44] off-label high prevalence use, lack of reliable safety and pharmacokinetic data from clinical trials, drug-induced growth and development disorders as delayed ADRs not ndable in adults [10,45]. To overcome this, authors recommended conducting paediatric pharmacoepidemiological studies on top of spontaneous reporting [10,45].…”

Section: Discussionmentioning

confidence: 99%

Social media as a source of drug safety information in the paediatric population

Vilimelis-Piulats

Pérez-Ricart

Calvo

et al. 2022

Preprint

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Purpose: Children are vulnerable to suffer negative outcomes due to medication (NOM), social media (SM) can be a non-interventional tool to gather safety data. The aim of this study is to assess paediatric Adverse Events (AE) or suspected Adverse Drug Reaction (ADR) detected in SM. Secondary objectives are the assessment of NOM, Drug Related Problems (DRP) and Medication Errors (ME). Methods: Observational, ambispective study assessing NOM in Public Parenting Forums (PPF) using data mining software. Entries that mentioned a medicine administered to children were analyzed and, if NOMs were detected, DRP, ME and AE were categorized. ME and ADR seriousness were assessed. ADR causality according Liverpool Causality Assessment (LCAT) and prevalence compared with those reported in Summary of Product Characteristics (SmPC) of each product. Results: Two forums (mumsnet.uk; socpetit.cat 2733 (81%)) were analyzed. Of 3375 entries, 635 contained a NOM and a DRP, 214 in English, 6 in Spanish and 217 in Catalan. 161 ADR were detected, including Serious AEs (SAEs), unknown, rare or very rare ADR. 29(16%) were not reported in SmPC. 95 ME were found, caused parents or caregivers (40; 42%) and healthcare professionals (HCP) (55; 58%). Severity ranged from no harm up to harm required intervention. Conclusion: ADR were found in PPF, including SAEs and ADR with low or unknown prevalence and suspect ADRs not included in the SmPC. ME that reached children were also found. As consequence, despite that the overall number of entries is not high, forums are a source of valuable pharmacovigilance information.

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Medicamentos utilizados en pediatría extrahospitalaria: ¿disponemos de información suficiente?

Cited by 21 publications

References 40 publications

Utilização de medicamentos na Pediatria: a prática de automedicação em crianças por seus responsáveis

Utilização de medicamentos na Pediatria: a prática de automedicação em crianças por seus responsáveis

An intensive monitoring of adverse drug reactions in pediatric hospitalized patients of a tertiary care hospital

Social media as a source of drug safety information in the paediatric population

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