Médicaments à l’origine d’insuffisances rénales aiguës allergiques en France en 2013

Leven, Cyril; Hudier, L.; Picard, Sylvie; Longuet, Hélène; Lorcy, Nolwenn; Cam, G.; Boukerroucha, Zakaria; Dolley-Hitze, Thibault; Cacheux, P. Le; Halimi, Jean‐Michel; Gall, Emilie Cornec-Le; Hanrotel-Saliou, Catherine; Arreule, A.; Massad, M.; Duveau, Agnès; Couvrat-Desvergnes, Grégoire; Renaudineau, Éric

doi:10.1016/j.lpm.2014.03.032

Cited by 20 publications

(3 citation statements)

References 15 publications

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“…It is the only investigation providing a prognostic evaluation by detailed analysis of patient’s time on dialysis. The annual AIN incidence of 1/100 000 is comparable to recent population-based data found in Scotland [40] and France [16], and earlier data from Germany [41]. With 17 patients temporarily needing and 5 patients remaining on RRT, AIN requiring biopsy diagnosis must be considered as a severe and life-threatening disease, comparable to crescentic glomerulonephritis.…”

Section: Discussionsupporting

confidence: 76%

Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: a 20-year registry-based case series

Wendt

Schliecker

Beige

2019

Clinical Kidney Journal

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Background Acute interstitial nephritis (AIN) is a renal injury causing renal function deterioration and requiring renal replacement therapy (RRT) in a substantial number of cases. Therapy is based on withdrawal of suspicious causative drugs or the underlying diseases and/or steroid application if renal function is not restored after cessation of the underlying condition. Hard clinical evidence for augmenting steroid therapy is not available. Methods We reviewed the course and diagnosis for >20 years among all 1126 biopsied samples of our tertiary renal centre. Results 49 (4.4%) were diagnosed with primary AIN, corresponding to an annual incidence of 1/100 000 population; 17 out of 49 biopsy-proven AIN patients required short-term or long-term (n = 5) RRT. According to a combined outcome criterion of coming off dialysis and/or reaching serum creatinine <200 µmol/L, 19 patients reached recovery whereas 20 did not. Among 39 patients with a comprehensive clinical and histopathological data set, presence of cortical scars, AIN histological activity (acute leucocyte infiltrates) and proteinuria were baseline parameters discriminating significantly between groups with or without recovery. No associations with the presence of specific drugs were found. Therapeutic use of steroids was associated with a lower probability of recovery (P = 0.008), presumably due to inclusion bias. Conclusions Following our basic finding of the importance of histopathological parameters of acuity associated with recovery, we argue for the inauguration of grading measures to characterize this issue quantitatively and make it usable for future controlled investigations. Finally, we provide a suggestion for a therapeutic algorithm in the management of AIN.

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Section: Discussionsupporting

confidence: 76%

Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: a 20-year registry-based case series

Wendt

Schliecker

Beige

2019

Clinical Kidney Journal

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“…[ 28 ] Many clinicians have expressed concerns about the safety implications of the misuse of PPIs due to widespread availability of these drugs and a lack of regulation. [ 20 , 39 , 40 ] PPIs are more frequently used by the elderly population than by the young people, which may contribute to a higher prevalence of AIN and CKD as well as a higher proportion of patients in need of dialysis. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

Drug rash with eosinophilia and systemic symptoms and severe renal injury induced by proton pump inhibitor therapy

He¹,

Ying²,

Fei³

et al. 2020

Medicine

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Introduction: Proton pump inhibitors (PPIs) are widely prescribed and generally well tolerated but can rarely cause severe allergic reactions, such as drug rash with eosinophilia and systemic symptoms (DRESS). We report a case of DRESS and renal injury induced by PPIs, and describe the therapeutic process. Patient concerns: The patient was a 66-year-old female who complained of fever, pruritus, desquamation, erythema multiforme, and anuria caused by omeprazole taken for 2 weeks to treat abdominal distention. Diagnosis: The clinical history revealed a similar episode of PPI-induced fever, eosinophilia, and acute kidney injury more than 1 year ago. The present laboratory tests revealed eosinophilia and oliguric renal failure. The renal biopsy was performed subsequently and proved the diagnosis of PPI-induced DRESS. Interventions: After the suspected diagnosis of PPI-induced DRESS, omeprazole was discontinued and methylprednisolone infusion (40 mg qd) was initiated. Because of oliguric renal failure, the patient received intermittent hemodialysis. Outcomes: The patient initially responded to omeprazole discontinuation, hemodialysis, and glucocorticoids but later died from severe infection during the tapering of glucocorticoid therapy. Conclusion: Clinicians should remain on high alert for potential life-threatening complications when prescribing PPIs. If unexplained renal injury develops in a patient taking a PPI, renal biopsy may help in identifying the pathogenesis and might facilitate timely intervention.

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“…Indeed, Cam et al reported that fluindione-induced IN often have an unfavorable evolution to severe chronic renal failure and chronic dialysis. Recently, Leven et al [ 9 ] showed in a retrospective study that 33% of drug-induced IN are induced by vitamin K antagonists and in nearly 90% of cases by fluindione. Two cases of drug-induced IN to warfarin have indeed been described [ 8 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Reversible Fluindione-Induced Chronic Interstitial Nephritis

Crépin

Bamoulid

Courivaud

et al. 2016

Case Reports in Nephrology

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Médicaments à l’origine d’insuffisances rénales aiguës allergiques en France en 2013

Cited by 20 publications

References 15 publications

Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: a 20-year registry-based case series

Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: a 20-year registry-based case series

Drug rash with eosinophilia and systemic symptoms and severe renal injury induced by proton pump inhibitor therapy

Reversible Fluindione-Induced Chronic Interstitial Nephritis

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