Medication Adherence and Quality of Life Among Epilepsy Patients: A Cross Sectional Study

Permatananda, Pande Ayu Naya Kasih; Apsari, Putu Indah Budi; Harkitasari, Saktivi

doi:10.29121/granthaalayah.v7.i3.2019.937

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Sample characteristics, such as age, gender, blood pressure, BMI, fasting blood glucose levels, and blood glucose control in the form of HbA1c, can also impact the results. [15][16][17] Several factors including the complex process of a gene causing DN might cause difference result in every subject. The IL-6 gene is a gene encoding the IL-6 cytokine.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-6 gene polymorphism (rs1800796) in patient with diabetic nephropathy among Balinese

Wati,

Lestarini,

Aryastuti

et al. 2023

JKKI

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Background: Diabetic Nephropathy (DN) is the most common complication of diabetes mellitus. Interleukin 6 (IL-6) known as pro-inflammatory cytokine increases extracellular matrix expression and proliferation in DN progression. One single nucleotide polymorphism (SNP) of the Interleukin (IL)-6 gene, rs1800796 play a role in the progression of DN among Asian. Objective: This research seeks to investigate the correlation between IL-6 gene polymorphism (rs1800796) and diabetic nephropathy in individuals diagnosed with type 2 diabetes mellitus (T2DM) among the Balinese population.Methods: This research employed an observational approach through a case-control design involving a total of 60 subjects for each group selected by a simple random sampling method. The occurrence of the rs1800796 polymorphism was identified through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotype and allele distribution acquired in this study were assessed using the chi-square (χ2) test and Hardy-Weinberg equilibrium law.Results: There were no significant differences identified in the occurrence of (DN) based on the genotype or allele distribution of the IL-6 gene rs1800796. Genotype CG-GG had a higher risk of becoming DN with Odd ratio 1.230, but not statistically significant (p=0.577). Allele G with OR 1.198 (p=0.502) was not significant in causing DN. Conclusion: No significant association was identified between IL-6 polymorphism (rs1800796) and diabetic nephropathy in Balinese individuals with type 2 diabetes mellitus. The lack of association could be due to the presence of other haplotypic connections or might require a larger sample size for conclusive results.

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Section: Discussionmentioning

confidence: 99%

Interleukin-6 gene polymorphism (rs1800796) in patient with diabetic nephropathy among Balinese

Wati,

Lestarini,

Aryastuti

et al. 2023

JKKI

View full text Add to dashboard Cite

show abstract

“…So addressing the issue of low and medium medication adherence may well be a very cost effective in addition to the better management of epilepsy [12]. Past literature on the subject matter has continued to give more emphasis to either by merging low and medium adherence as nonadherence [13][14][15] or good and medium adherence as full adherence [16][17][18] ignoring the signi cant factors for each low and medium adherence as a critical component of suboptimal adherence.…”

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confidence: 99%

Assessment of Low and Medium Anti-epileptic Medication Adherence among Epileptic Patients in Dessie Comprehensive Specialized Hospital, North-East Ethiopia: Cross Sectional Study

Fissha

Kibret

Haile

2022

Preprint

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Background Non-adherence to anti-seizure medication therapy is an important contributing factor to the higher mortality rate and treatment failure of epilepsy. Complete antiepileptic therapy is an essential intervention aimed at improving the quality of life of patients who suffer from a disease which is known for its stigmatization with many cultural misconceptions. So the aim of this study was to assess low and medium anti-epileptic medication adherence among epileptic patients in Dessie comprehensive specialized hospital, north-east Ethiopia. Method A cross sectional study design was conducted among the epileptic patient attending Dessie comprehensive specialized hospital from May 4 to August 4, 2022, on the total sample size of 253 selected epileptic patients by using convenient sampling technique. Data was collected by using structured interview-administered quastitionary; its quality was checked by pretest and continuous supervision. Data was entered into Epi-data 3.1 version and exported to SPSS version 23 for analysis. Multivariable multinomial logistic regression model was used to determine the relationship between the independent variable and the outcome variable. Relative risk ratio (RRR) with 95% confidence interval was used at p value less than 0.05 to declare statistical significance association. Result From 253 study participants, this study found a 20.2%, and 30.8% incidence of the low and medium anti-epileptic drug adherence respectively. The factors for low anti-epileptic drug adherence were seizure since last visit (RRR = 1.033, 95% CI, (1.005–1.219), comorbidity of patient (RRR = 36.389, 95% CI, (7.198-183.963), adverse effect experiences since last visit (RRR = 3.938, 95% CI, (1.065–14.565), and duration of drug (RRR = 56.745, 95% CI, (.903-3567.210). The factors for medium anti-epileptic drug adherence were seizure since last visit (RRR = (1.305, 95% CI, (1.101–1.920), occupation status of the patient (RRR 1.008, 95% CI, (1.01–1.156), rural residents (RRR = 1.031, 95% CI, (1.008–1.120), and age category 18–27 (RRR = .161, 95% CI, (.031-.835). Conclusion The prevalence of low and medium antiepileptic drug adherence was high in this study. Health care providers should provide health education and medication related counseling for all patients with epilepsy to improve adherence.

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A study to assess medication adherence and quality of life among epilepsy patients seeking treatment at AIIMS Bhopal

Pallavi,

Verma,

Gupta

et al. 2024

Journal of Family Medicine and Primary Care

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Background: Epilepsy is a disorder of the brain with a permanent predisposition to produce epileptic seizures. There are cognitive, psychological, neurological, and social causes of this condition. It is the second most common problematic neurologic disorder, affecting more than 70 million people throughout the world. More than 65% of the global burden of epilepsy occurs in developing countries. Objective: To assess medication adherence and quality of life among epilepsy patients and to find any correlation between medication adherence and quality of life. Material and Methods: This descriptive study was conducted on epileptic patients who were seeking treatment at AIIMS Bhopal. Two hundred epileptic patients were enrolled in this study via purposive sampling techniques. Data was collected through face-to-face interview method. The data was analysed using descriptive and inferential statistics Results: In this study, a total of 200 patients with epilepsy were found to be eligible to participate; there were 23 patients (11.5%) with low medication adherence, 95 patients (47.5%) with moderate medication adherence, and 82 patients (41%) with high medication adherence. Patients with epilepsy who follow recommended treatment have a good quality of life, particularly in the spiritual sector (169; 85%). The overall quality of life is moderate for 142 patients (71%) and good for 58 patients (29%). Medication adherence and quality of life were shown to be strongly positively correlated, with a Karl Pearson correlation coefficient of 0.67. Conclusion: The result of this study concluded that improving medication adherence is important to improving the quality of life among epilepsy patients.

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Medication Adherence and Quality of Life Among Epilepsy Patients: A Cross Sectional Study

Cited by 3 publications

References 20 publications

Interleukin-6 gene polymorphism (rs1800796) in patient with diabetic nephropathy among Balinese

Interleukin-6 gene polymorphism (rs1800796) in patient with diabetic nephropathy among Balinese

Assessment of Low and Medium Anti-epileptic Medication Adherence among Epileptic Patients in Dessie Comprehensive Specialized Hospital, North-East Ethiopia: Cross Sectional Study

A study to assess medication adherence and quality of life among epilepsy patients seeking treatment at AIIMS Bhopal

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