Objectives
Corneal transplantation is the most common transplant worldwide and its
success critically depends on the management of corneal graft rejection
through topical steroid therapy during the first 12 months after surgery.
There is currently no published data on adherence after keratoplasty. This
pilot study aims to explore the adherence to topical steroid after
penetrating keratoplasty using a smart electronic device.
Methods
Thirty patients undergoing penetrating keratoplasty were included to evaluate
the adherence to topical dexamethasone medication for 12 months after
surgery. Patients received the usual post-transplantation treatment (topical
dexamethasone) and follow-up after surgery (day 15, months 1, 2, 3, 4, 5, 6,
9, and 12). Adherence to treatment was monitored using the KaliJAR device
(Kali Care, Santa Clara, CA, USA), which recorded the number of single-dose
units (SDU) discarded. At control visits, data recorded by the device were
compared to the manually count of SDU. Adherence ratio and individual
adherence curve were explored for all patients.
Results
Data from 27 patients showed a high agreement between adherence ratio
calculated based on the device data and obtained from manual counting of the
discarded SDU (intraclass coefficient correlation of 0.87 [95% CI:
0.738–0.938]). Mean adherence to the treatment over the 12-month study
period was 95.2 ± 4%.
Conclusions
Adherence to topical dexamethasone for 12 months after corneal
transplantation was high. The connected device was able to record accurately
the discarded SDU. This approach would be a particular interest in the early
identification and personalized follow-up of poorly adherent patients.