Background: Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the characteristic of hyperglycemia. It is associated with abnormalities in carbohydrate, fat, and protein metabolism and results in chronic complications including microvascular, macrovascular, and neuropathic disorders. Evidence indicates that it is the level of blood glucose, which the patients can achieve during their treatment, influences diabetic complications on the long run. Achievement of optimal blood sugar level is generally based appropriate utilization of existing oral antidiabetic drugs, proper adherence to prescribed regimens and patients' own managements of their illness. The study was, therefore, aimed to assess adherence to oral antidiabetic drugs among diabetic patients attending chronic ambulatory wards of Hiwot Fana Specialized University Hospital (HFSUH).