Medication adherence to antiretroviral therapy among newly treated people living with HIV

Yang, Yu; Luo, Dan; Chen, Xi; Huang, Zhulin; Wang, Min; Xiao, Shuiyuan

doi:10.1186/s12889-018-5731-z

Cited by 70 publications

(75 citation statements)

References 43 publications

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“…PNS and PrEP together motivated providers to offer services for couples rather than individuals, including the opportunity for both partners to know their HIV status together. Mutual support in treatment decision‐making can improve clinic attendance and adherence [,]. We found that providers repeatedly brought up anecdotal cases in which the availability of PrEP encouraged persons living with HIV who had been poorly adherent to ART to bring in partners for testing and PrEP linkage and that in turn resulted in improved ART use as well.…”

Section: Discussionmentioning

confidence: 99%

Integrating PrEPintoHIVcare clinics could improve partner testing services and reinforce mutual support among couples: provider views from a PrEPimplementation project in Kenya

et al. 2019

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Introduction Partner notification services (PNS) increase the HIV status knowledge and linkage to care and treatment. However, it is unclear if PNS can facilitate linkage of HIV‐negative partners to prevention services such as pre‐exposure prophylaxis (PrEP). Using qualitative methods, we explored provider perspective regarding the interaction of PrEP availability, PNS and antiretroviral treatment (ART) outcomes within a project integrating PrEP services into HIV care clinics in eight counties in western and central Kenya. Methods From May 2017 to August 2018, data on integrated PrEP service delivery including its interaction with PNS were collected through 71 key informant in‐depth interviews with healthcare providers and 24 standardized technical assistance reports summarizing implementation at the participating clinics. Thus, the perspective was from that of providers; analyses focused on emergent themes relating PNS to PrEP and ART services. Results Providers found that PrEP integration provided an additional concrete prevention option for HIV‐negative partners and created a motivation to offer PNS to persons living with HIV. PrEP availability also seemed to operate as an incentive for those living with HIV to participate in PNS, which in turn enhanced identification of potential PrEP clients and created an environment for discussing HIV transmission risk. Providers commented that initiating HIV‐negative partners on PrEP enhanced mutual monitoring of health outcomes, including improved adherence to ART by partners living with HIV. Clinics noted prioritizing people living with HIV with detectable viral loads for PNS in order to identify HIV‐negative partners who would benefit most from PrEP. Providers felt motivated by the apparent synergistic interaction of PNS, PrEP and ART. Conclusions Providers felt that the integration of PrEP into HIV care clinics stimulated the provision of PNS, and PNS was used to improve the identification of potential PrEP clients. The integrated combination of PNS, PrEP and ART is synergistic and should be promoted in HIV clinics.

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Section: Discussionmentioning

confidence: 99%

Integrating PrEPintoHIVcare clinics could improve partner testing services and reinforce mutual support among couples: provider views from a PrEPimplementation project in Kenya

et al. 2019

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“…For example, negative perceptions regarding quality of overall care received may sabotage adherence 6 . At the same time, medicationrelated challenges could also complicate overall treatment and adherence [7][8][9] . Other barriers to adherence include inconvenient dosing schedules, stigma, medication-related privacy concerns, emotional challenges, and polypharmacy (drug-drug interactions) [10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Treatment aspirations and attitudes towards innovative medications among people living with HIV in 25 countries

Okoli¹,

Young²,

Allan³

et al. 2020

Popul. Med.

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INTRODUCTION The worldview in relation to patient care has shifted from conquering diseases to improving overall wellbeing and quality of life. We examined treatment aspirations among people living with HIV (PLHIV). METHODS In all, 2389 PLHIV were surveyed in the 25-country 2019 Positive Perspectives Study. Descriptive and multivariable analyses were used to explore attitudes towards treatment. RESULTS Participants were from: Northern America (USA, Canada), 21.8% (520/2389); Europe, 46.8% (1119/2389); and other international regions, 31.4% (750/2389). Factors associated with some level of dissatisfaction with HIV medication among those otherwise fully satisfied with their HIV management included being on a multi-tablet regimen (AOR=2.76; 95% CI: 1.93-3.96), reporting polypharmacy (AOR=2.10; 95% CI: 1.45-3.03), and experiencing side effects from current HIV medication (AOR=2.12; 95% CI: 1.49-3.02). Of seven improvements to HIV medications assessed, the percentage ranking each attribute, as the first or second most important, was: 'reduced long-term impact on my body' (46.7%); 'longer-lasting medicine so I don't have to take it every day' (43.1%); 'fewer side effects' (40.5%); 'less HIV medicine each day but just as effective' (25.4%); 'less chance of affecting other medicines' (21.6%); 'no food restrictions/ requirements' (14.0%); and 'smaller pills' (8.7%). Overall, 77.1% (1842/2389) believed 'future advances in HIV treatment will improve my overall wellbeing', 72.2% (1726/2389) were 'open to taking an HIV treatment composed of fewer medicines', while 54.7% (1306/2389) expressed openness towards longer-acting (non-daily) HIV medication. Compared to those not fully satisfied with either their HIV medication or management, those fully satisfied with both reported significantly higher prevalence of optimal treatment adherence (89.2% [372/417] vs 69.5% [763/1098]) and optimal overall health (70.3% [293/417] vs 47.8% [525/1098]) (all p<0.001). CONCLUSIONS Many PLHIV perceived gaps in their care and aspired for novel treatments. Providing flexible treatment options can help patients across the spectrum of unmet needs and improve health-related quality of life.

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“…In China, where the COVID-19 outbreak was first identified, people living with HIV (PLWH) have experienced critical challenges and barriers to optimal care outcomes. It may be important to note that prior to the COVID-19 outbreak, PLWH in China were already affected by high levels of HIV stigma [1], psychological distress (depression, anxiety) [2][3][4], and suboptimal adherence [5,6]. For instance, in two most recent large sample survey studies (conducted in 2013-2015) among PLWH in China, 32.9-38.4% PLWH reported depressive symptoms and 27.4% experienced anxiety symptoms [7,8].…”

mentioning

confidence: 99%

Challenges to HIV Care and Psychological Health During the COVID-19 Pandemic Among People Living with HIV in China

et al. 2020

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Medication adherence to antiretroviral therapy among newly treated people living with HIV

Cited by 70 publications

References 43 publications

Integrating PrEPintoHIVcare clinics could improve partner testing services and reinforce mutual support among couples: provider views from a PrEPimplementation project in Kenya

Integrating PrEPintoHIVcare clinics could improve partner testing services and reinforce mutual support among couples: provider views from a PrEPimplementation project in Kenya

Treatment aspirations and attitudes towards innovative medications among people living with HIV in 25 countries

Challenges to HIV Care and Psychological Health During the COVID-19 Pandemic Among People Living with HIV in China

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