Medication-induced oesophageal injury leading to broncho-oesophageal fistula

McAndrew, N.; Greenway, M W

doi:10.1136/pgmj.75.884.379

Cited by 8 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several reports, either as sole cases or as small cohorts of patients, describe broncho-oesophageal communications as the result of malignancy, 6 inflammation, 7–11 trauma, 12,13 iatrogenic procedures 14–16 or drug-induced oesophageal injury. 17 Graph 1 demonstrates a schematic classification of BOFs according to their aetiology.…”

Section: Discussionmentioning

confidence: 99%

Congenital broncho-oesophageal fistula: An unusual cause of persistent pneumonia in a young adult

Savvidou

Pasoglou

Kyparisia

et al. 2013

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

A 19-year-old female with a 3-day history of high temperature, productive cough and dyspnoea was admitted due to diabetic ketoacidosis and pneumonia of the right lower lobe. Antibiotics (amoxicillin-clavulanic acid), insulin, fluids and electrolytes were administered, as appropriate. The patient was doing well (normal temperature, normal glucose levels, normal acid-base balance) until the sixth day of hospitalization, when she reported bouts of cough when swallowing liquids. Barium oesophagography revealed the presence of a broncho-oesophageal fistula (BOF). Congenital BOFs are rare developmental malformations (only just over 100 reported cases in the literature), which are attributable to persistent attachments between the tracheobronchial tree and the oesophagus. When not combined with oesophageal atresia, symptoms may not appear until adult life. History of recurrent respiratory infections, bronchiectasis, haemoptysis and chronic cough associated with eating, may indicate investigation with conventional or multi-positional oesophagography. At the time that surgery was decided, our patient developed persistent pneumonia of both the middle and the lower right lobes. A fistulous tract between the medial segmental bronchus and the oesophagus was removed, along with right middle lobectomy. Post-operative clinical course was excellent.

show abstract

Section: Discussionmentioning

confidence: 99%

Congenital broncho-oesophageal fistula: An unusual cause of persistent pneumonia in a young adult

Savvidou

Pasoglou

Kyparisia

et al. 2013

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

show abstract

“…6 Additionally, vascular compromise of the conduit may predispose to fistula formation. 7 Treatments for bronchoesophageal fistulas have included the application of sealants such as silver nitrate and sodium hydroxide to the esophageal and bronchial ostia of the fistula. 8 It is possible that such a procedure may also work for colobronchial fistulas.…”

Section: Discussionmentioning

confidence: 99%

Colobronchial Fistula as a Rare Complication of Coloesophageal Interposition: A Unique Treatment with a Review of the Medical Literature

Zhao

Sandhu

Kiev

2005

The American Surgeon™

View full text Add to dashboard Cite

Colobronchial fistula after coloesophageal interposition is a rare complication that has only been reported once in the English surgical literature. We report the case of a 53-year-old man who presented with chronic respiratory complaints. He had previously undergone esophagectomy for adenocarcinoma of the gastroesophageal junction. The fistula was controlled by placement of a Polyflex esophageal stent.

show abstract

“…Not surprisingly, hemorrhage, which may be severe 19 , is a common complication of these esophageal ulcers, especially when compared with other medication related esophagitis. Broncho-esophageal fistula has also been reported 20 . Notably, it is over-the-counter use of NSAIDs that is most commonly associated with injury 21 , in keeping with their more commonly used venue.…”

Section: Endoscopic Featurementioning

confidence: 95%

Clinical and Endoscopic Characteristics of Medication Induced Esophageal Injury

Hasan¹,

Mondal²,

Perveen³

et al. 2020

Faridpur Med Coll J

View full text Add to dashboard Cite

Medications can cause several complications in the esophagus and lead to medication-induced esophageal injury. This study was carried out among patients diagnosed as medication-induced esophageal injury from June 2015 to October, 2018 in the Department of Gastroenterology, Enam Medical College and Hospital, Savar, Dhaka to investigate clinical and endoscopic characteristics of medication-induced esophageal injury as well as outcome of these patients with treatment. Patients diagnosed as malignancy, viral or fungal esophagitis, esophageal varix, corrosive and sclerotherapy induced ulcer and GERD were excluded. Clinical and endoscopic characteristics of patients diagnosed as medication-induced injury were analyzed. After given treatment, clinical improvements as well as mucosal healing of oesophageal injury were noted. Thirty seven patients were diagnosed as medication-induced esophageal injury. Their median age was 40; 17 were males and 20 were females. Common symptoms were chest pain (94.6 %), odynophagia (78.4 %) and dysphagia (62.2 %). Symptoms appeared between 3 hours to 15 hours after ingestion of medication. Predisposing factors for 75.67% of the patients were related to taking the medicine with insufficient water or in recumbent position, or both. The main causative agents were antibiotics, Non-steroidal anti-inflammatory drugs (NSAIDs) and Alendronate sodium. Common diseases that required treatment with these drugs were various urinary system diseases, osteoporosis and migraine. During endoscopy, 25 had only ulcer, 7 had only erosion and 5 had both ulcer and erosion. Most of the ulcers and erosions were located at the middle third of the oesophagus with a rate of 70%, and 58.3% respectively. Appearance of the ulcer was oval, circular, kissing and geographical shaped and their sizes vary between 6 mm to 18 mm and single or multiple in numbers. All the patients were treated with proton pump inhibitors (PPIs) or sucralfate, and the causative drugs were discontinued. Symptoms resolution occurred within 5 to 12 days after treatment and mucosal healing were detected in all patients after 4 weeks who were performed endoscopy. Almost every kind of medication, particularly doxycycline, NSAIDs can cause oesophageal ulcer and erosion. It can be successfully treated with PPIs and discontinuation of the causative medication and prevented by warning patients about drinking water sufficiently and sitting up while taking the pill. Faridpur Med. Coll. J. Jan 2019;14(1): 2-7

show abstract

Medication-induced oesophageal injury leading to broncho-oesophageal fistula

Cited by 8 publications

References 8 publications

Congenital broncho-oesophageal fistula: An unusual cause of persistent pneumonia in a young adult

Congenital broncho-oesophageal fistula: An unusual cause of persistent pneumonia in a young adult

Colobronchial Fistula as a Rare Complication of Coloesophageal Interposition: A Unique Treatment with a Review of the Medical Literature

Clinical and Endoscopic Characteristics of Medication Induced Esophageal Injury

Contact Info

Product

Resources

About