Medication-induced Pneumatosis Intestinalis

Duncan, Burris; Barton, Leslie L.; Eicher, Martha; Chmielarczyk, Vince T.; Erdman, Steven H.; Hulett, Rebecca L.

doi:10.1542/peds.99.4.633

Cited by 26 publications

(20 citation statements)

References 13 publications

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“…PI may be due to colonoscopies, (6) ileal surgery, (7) chronic pulmonary disease, (8) connective tissue disorder, (9) and ingestion of lactulose/sorbitol. (10,11) In our case, the etiology was also unknown.…”

Section: Histopathology Reportmentioning

confidence: 66%

Intussusception Secondary to Pneumatosis Intestinalis: A Rare Case Report

Prabhat¹

2017

jmscr

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Section: Histopathology Reportmentioning

confidence: 66%

Intussusception Secondary to Pneumatosis Intestinalis: A Rare Case Report

Prabhat¹

2017

jmscr

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“…The etiological mechanisms are unclear, although PCI reportedly develops in association with raised intra-intestinal pressure due to ileus (11), surgery (12), colonoscopy (13), respiratory conditions such as chronic bronchitis and emphysema (14), trichloroethylene exposure (15), connective tissue diseases (16), immunosuppressant therapy (1), ingestion of carbohydrates such as lactulose (17) and sorbitol (18), and counter-perfusion super-saturation (19).…”

Section: Discussionmentioning

confidence: 99%

Pneumatosis Cystoides Intestinalis Induced by the Alpha-glucosidase Inhibitor Miglitol

Kojima¹,

Tsujimoto

Fujii

et al. 2010

Intern. Med.

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Pneumatosis cystoides intestinalis (PCI) is a rare condition in which pneumocysts develop in the submucosa or subserosa of the colon. We report herein a case of PCI induced by the alpha-glucosidase inhibitor (αGI) miglitol. There have been 9 recorded cases of PCI induced by other αGIs, but this is the first report of miglitol causing PCI. The PCI lesions in our case were smaller than those induced by voglibose or acarbose. The possibility of PCI should be considered in diabetic patients on αGI therapy who complain of gastrointestinal symptoms, and the gastrointestinal tract should be thoroughly investigated in these patients.

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“…Two case reports have documented a mechanical aetiology in children post-blunt abdominal trauma [4,5]. Furthermore, one child with cerebral palsy developed PI following ingestion of sorbitol-containing medications [6]. This report describes a child who sustained severe traumatic brain injury (TBI) without abdominal trauma who developed PI after receiving multiple medications containing sorbitol.…”

Section: Introductionmentioning

confidence: 99%