Medication Related Osteonecrosis of the Jaw (MRONJ). Review and recent advances

Abstract

Background The presence of lymph node metastasis is one of the most important prognostic factors for long-term survival of patients with colorectal cancer. Therefore, thorough pathologic examination of at least 12 lymph nodes is essential for accurate staging of this disease, as well as for choosing the best adjuvant treatment. The aim of this study is to assess the adequacy of lymph node harvest in patients with colorectal cancer. Methods This observational, cross-sectional study was performed on 584 patients with colorectal adenocarcinoma who had undergone surgery from 2012 to 2017. Thereafter, the relevant demographic, pathological, and surgical data were extracted from the patients' medical records; and a relationship between the number of evaluated lymph nodes and other variables was also assessed. Results Among 584 studies cases in this study, 336 (57.5%) subjects had fewer than 12 evaluated lymph nodes. Mean and median number of the evaluated lymph nodes were calculated as 10.7 (±5.6) and 10, respectively. The patients aged 60 years old and older and the cases with tumors located in descending colon and rectum were observed to have a higher likelihood of inadequate lymph node retrieval. After an average follow-up of a 60-month period, 63% of the patients were alive. For the patients in whom fewer than 12 lymph nodes had been assessed, the median survival was estimated to be 48 months. For the patients in whom the number of evaluated lymph nodes was ≥12, median survival was calculated to be 54 months. Conclusion The number of lymph nodes evaluated in our study was less than the standard number in more than half of the patients. Among various other factors, older age and tumor location in descending colon and rectum are found to be associated with suboptimal assessment of lymph nodes. The number of lymph nodes dissected is also associated with survival.

Good Oral Health Can Prevent or Reduce the Severity of Oral Toxicities in Cancer Therapies

“…Painful oral mucosal ulcers, bleeding, and oral mucosal infections during cancer therapy, or necrosis of the jaw bones, weeks, and months after therapy, may appear as new toxicities, and need our attention to early and effective diagnosis and management [8]. Cases of dental infection and abscess may be representing an early-stage osteonecrosis of the jaw [9].…”