Medication-related risk factors associated with health-related quality of life among community-dwelling elderly in China

Zhang, Sha; Meng, Long; Qiu, Feng; Yang, Jiadan; Sun, Shusen

doi:10.2147/ppa.s156713

Cited by 15 publications

(13 citation statements)

References 44 publications

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“…The findings of this study that sociodemographic characteristics, including age, BMI, education, and income, had a significant effect on HRQoL are consistent with those of several previous studies. HRQoL has been shown to decrease with age [26,27], and Kvamme et al [28] reported that, within the BMI categories, moderately overweight individuals had the highest HRQoL. Furthermore, the finding that higher educational and income levels were associated with a high HRQoL is consistent with that of a previous study in middleaged and elderly adults showing that individuals in the higher education and income groups had a higher HRQoL than those in the lower education and income groups [29][30][31][32].…”

Section: Discussionsupporting

confidence: 76%

The impact of osteoporosis on health-related quality of life in elderly women

Park¹

2018

biomedicalresearch

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Objective of this study was to assess the impact of osteoporosis on health-related quality of life (HRQoL) in elderly Korean women. Sociodemographic characteristics, medical history of osteoporosis, and the EuroQol-5 dimension questionnaire scores for 1,000 female participants aged 60 years or older were obtained from the 2015 Korean National Health and Nutrition Examination Survey (KNHANES). Demographic variables, including age, educational level and income, were significantly associated with HRQoL. Furthermore, osteoporosis had a significant effect on HRQoL in elderly Korean women. In the osteoporosis group, the adjusted odds ratios for disability on the ED-5Q dimensions were 1.92 (95% confidence interval (CI)=1.44-2.58, p<0.001) for mobility, 1.90 (95% CI=1.45-2.51, p<0.001) for pain/ discomfort, and 1.89 (95% CI=1.36-2.61, p=0.001) for usual activities. These findings indicate that osteoporosis has a significant impact on HRQoL and suggest that the prevention and treatment of osteoporosis may significantly improve quality of life in elderly women.

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Section: Discussionsupporting

confidence: 76%

The impact of osteoporosis on health-related quality of life in elderly women

Park¹

2018

biomedicalresearch

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“…Also, polypharmacy was inversely associated with patients’ overall HRQoL, as assessed with the EQ-5D index score in all the three multiple linear regression models. These findings are consistent with some previous studies [ 36 , 37 ].…”

Section: Discussionsupporting

confidence: 94%

“…Also, polypharmacy was inversely associated with patients' overall HRQoL, as assessed with the EQ-5D index score in all the three multiple linear regression models. These findings are consistent with some previous studies [36,37]. This study also indicated that patients with prolonged CNSD use had more intense pain then those without such use, and that pain intensity was associated with lower HRQoL.…”

Section: Discussionsupporting

confidence: 93%

Health-related quality of life in hospitalized older patients with versus without prolonged use of opioid analgesics, benzodiazepines, and z-hypnotics: a cross-sectional study

et al. 2020

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Background Central nervous system depressant medications (CNSDs) such as opioid analgesics and sedative-hypnotics are commonly prescribed to older patients for the treatment of chronic pain, anxiety and insomnia. Yet, while many studies reported potential harms, it remains unknown whether persistent use of these medications is beneficial for older patients’ self-reported health-related quality of life (HRQoL). The present study clarified this knowledge gap through comparing HRQoL of hospitalized older patients with versus without using CNSD drugs for ≥4 weeks. Moreover, we explored the relationship between such use and HRQoL, adjusting for the effects of polypharmacy, comorbidity burden and other clinically relevant covariates. Methods The study was cross-sectional and included 246 older patients recruited consecutively from somatic departments of a large regional university hospital in Norway. We defined prolonged CNSD use as using opioids, benzodiazepines and/or z-hypnotics for ≥4 weeks. Patients’ self-reported HRQoL were measured with scales of the EuroQol EQ-5D-3L instrument. Data analyses were mainly descriptive statistics and regression models. Results Patients with prolonged use of CNSDs reported lower scores on both EQ-5D index and EQ VAS compared with those without such use (p < 0.001). They had higher odds of having more problems performing usual activities (OR = 3.37, 95% CI: 1.40 to 8.13), pain/discomfort (OR = 2.06, 95% CI: 1.05 to 4.04), and anxiety/depression (OR = 3.77, 95% CI: 1.82 to 7.82). In multivariable regression models, there was no significant association between prolonged CNSD use and HRQoL when including pain as a predictor variable. In models not including pain, CNSD use was strongly associated with HRQoL (adjusted for sociodemographic background, polypharmacy, comorbidity, anxiety and depressive symptoms, regression coefficient − 0.19 (95% CI, − 0.31 to − 0.06). Conclusions Older patients with prolonged CNSD use reported poorer HRQoL. They also had more pain and higher depression scores. Prolonged use of CNSDs was not independently associated with higher HRQoL.

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“…These may include adverse events, the burden on day-today life, and the impact on social, financial, psychological, and functional well-being. [4][5][6][7][8] Health-related quality of life (HRQoL) is an essential treatment goal in pharmacotherapeutic interventions. However, most widely used HRQoL measures are not sensitive enough to detect the changes in HRQoL related to pharmacotherapy.…”

Section: Introductionmentioning

confidence: 99%