Medication Use and the Risk of Stevens–Johnson Syndrome or Toxic Epidermal Necrolysis

Abstract

The use of antibacterial sulfonamides, anticonvulsant agents, oxicam NSAIDs, allopurinol, chlormezanone, and corticosteroids is associated with large increases in the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. But for none of the drugs does the excess risk exceed five cases per million users per week.

Toxic Epidermal Necrolysis : A Case Report

“…Patient developed TEN about 6 weeks after initiation of ATT which manifested in the classic form. A delayed onset could be attributed to a short course of systemic steroids on initiation of ATT [4]. Management in ICU with burns protocol of fluid and electrolyte replenishment and intravenous antibiotics was beneficial to the patient.…”

A marker for Stevens-Johnson syndrome …: ethnicity matters

“…A limited number of drugs are associated with a high risk for SJS and TEN: several antiepileptic agents, especially carbamazepine, phenytoin, phenobarbital and lamotrigine, antibacterial sulfonamides, anti-inflammatory drugs of the oxicam family, allopurinol and the antiretroviral agent nevirapine. 1,2 Although the pathophysiology of SJS and TEN remains largely unknown, previous work suggests an immune mechanism involving a drug-dependent cytotoxic cell response against epidermal cells. Cytokines like TNFa and Fas ligand (FasL) may play a role in the final apoptosis of the keratinocytes, but the initial events triggering the adverse reaction remain to be identified.…”

Hospitalization for serious blood and skin disorders followinguse of co‐trimoxazole

“…Case histories were [1][2][3][4]. We have previously published the results of a population-based cohort study providing quantitative inforreviewed by the authors who gave strong consideration to the clinical diagnoses made by the physicians who cared for mation on the risk of co-trimoxazole-associated serious blood and skin disorders using data from the General Practice the patients.…”