Medication use in childhood dystonia

Lumsden, Daniel E.; Kaminska, Margaret; Tomlin, Stephen; Lin, Jean-Pierre

doi:10.1016/j.ejpn.2016.02.003

Cited by 66 publications

(44 citation statements)

References 16 publications

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“…Trihexyphenidyl has some evidence of efficacy to support its use in adults with dystonia. In a retrospective cohort of 278 children with dystonia referred to a single center from all over the United Kingdom and Republic of Ireland, medication use had been prospectively gathered including adverse drug reactions (ADR) (71). …”

Section: Exploration Of Better Pharmacological Approaches To Managingmentioning

confidence: 99%

“…Choice of medication appeared to be influenced by dystonia etiology (71). ADR had occurred in 171/278 (61.5%) of children: the commonest drugs responsible for ADR being trihexyphenidyl (90/171: 52.3%), baclofen (43/171: 25.1%), and l -dopa (26/171: 15.2%) (70).…”

Section: Exploration Of Better Pharmacological Approaches To Managingmentioning

confidence: 99%

“…ADR had occurred in 171/278 (61.5%) of children: the commonest drugs responsible for ADR being trihexyphenidyl (90/171: 52.3%), baclofen (43/171: 25.1%), and l -dopa (26/171: 15.2%) (70). Unfortunately, pharmacological management of dystonia in children is often disappointing or not tolerated (70, 71). No medication is licensed for the management of dystonia in childhood (70).…”

Section: Exploration Of Better Pharmacological Approaches To Managingmentioning

confidence: 99%

See 2 more Smart Citations

Recognizing the Common Origins of Dystonia and the Development of Human Movement: A Manifesto of Unmet Needs in Isolated Childhood Dystonias

Lin

Nardocci

2016

Front. Neurol.

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Dystonia in childhood may be severely disabling and often unremitting and unrecognized. Considered a rare disorder, dystonic symptoms in childhood are pervasive in many conditions including disorders of developmental delay, cerebral palsy (CP), autism, neurometabolic, neuroinflammatory, and neurogenetic disorders. Collectively, there is a need to recognize the role of early postures and movements which characterize phases of normal fetal, infant, and child development as a backdrop to the many facets of dystonia in early childhood neurological disorders and to be aware of the developmental context of dystonic symptoms. The role of cocontraction is explored throughout infancy, childhood, young adulthood, and in the elderly. Under-recognition of pervasive dystonic disorders of childhood, including within CP is reviewed. Original descriptions of CP by Gowers are reviewed and contemporary physiological demonstrations are used to illustrate support for an interpretation of the tonic labyrinthine response as a manifestation of dystonia. Early recognition and molecular diagnosis of childhood dystonia where possible are desirable for appropriate clinical stratification and future precision medicine and functional neurosurgery where appropriate. A developmental neurobiological perspective could also be useful in exploring new clinical strategies for adult-onset dystonia disorders focusing on environmental and molecular interactions and systems behaviors.

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Section: Exploration Of Better Pharmacological Approaches To Managingmentioning

confidence: 99%

Section: Exploration Of Better Pharmacological Approaches To Managingmentioning

confidence: 99%

Section: Exploration Of Better Pharmacological Approaches To Managingmentioning

confidence: 99%

See 1 more Smart Citation

Recognizing the Common Origins of Dystonia and the Development of Human Movement: A Manifesto of Unmet Needs in Isolated Childhood Dystonias

Lin

Nardocci

2016

Front. Neurol.

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“…6 Effects are limited, especially on the long term, and side effects may be poorly tolerated. 4,7,8 Botulinum toxin may be helpful for focal dystonic posturing, 9 but for most paediatric patients treatment implies repetitive injections under full anesthesia. Other management options such as intrathecal baclofen (ITB) may be efficient 10 , but possible risks such as respiratory depression, drooling, perioperative surgical complications, repeated need for surgical pump replacement, or life-threatening withdrawal due to catheter malfunction or missed pump refilling have to be outweighed against the potential benefit.…”

Section: Cerebral Palsymentioning

confidence: 99%

Deep brain stimulation in cerebral palsy: Challenges and opportunities

Koy

Timmermann

2017

European Journal of Paediatric Neurology

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“…Although pharmacological management is commonly ineffective in generalised and multifocal dystonia 7,8,9 and is often accompanied by unwanted and adverse side effects 10 . There has been increased focus on emergent neurosurgical interventions for the management of dystonia, and childhood dystonia is now being routinely managed with Deep Brain Stimulation (DBS), a reversible 'non-lesioning' neurosurgical treatment 7 but usually only after demonstrating that dystonia has proven refractory to accepted pharmacological management options 7 .…”

mentioning

confidence: 99%