Medications Impair Kidney Function in Stroke Population

Estimated glomerular filtration rate decline in 567 patients with acute stroke

“…Secondly, rather than the simple shared insults, gradual loss of kidney function may amplify the effect of risk factors via different levels, such as molecular changes in nitric oxide (NO) production and adaptive changes in vessel stiffness. Thirdly, the preconditions of haemorrhagic stroke, including medication, will affect the kidney function directly or indirectly [21,22]. However, based on the current findings, the authors strongly suggest that the neurologist should screen renal function in patients with acute stroke, especially haemorrhagic stroke.…”

“…As evidence, Tsagalis et al also found that renal function is a significant risk for new CVD morbidity over a 10-year period [9]. Another important fact is that renal impairment is a challenge and risk to current therapies in stroke [21]. Lyrer et al reported that decline in renal function is associated with increased odds for a poor outcome, with a trend towards more symptomatic intracranial haemorrhage in stroke patients treated with recombinant tissue plasminogen activator [23].…”