Medicative and preventive effects of enterosorbent noolit on anxious-depressive state in male mice

Silver containing sorbents: Physicochemical and biological properties

“…Granulometric composition was assessed by screen size gradation (0.1-1 mm); the particle size of micronised sorbent (TAGA) was assessed using laser diffractometer (SHIMADZU SALD-2101). Mechanical stability of slightly spherical sorbent specimens was assessed based on losses following mechanical abrasion PIG-2 [3]. The specific surface of sorbent specimens with different granulometric composition was determined based on the BET method, using nitrogen sorption isotherm to determine the size and the volume of pores [18].…”

“…The specific surface of sorbent samples of different granulometric content was from 100 to 270 m 2 /g, powder density -from 2.6 to 2.9 g/cm 3 (the parent matrix density approximately 3, depending on the content of silicon-containing component in the sorbent, the density of which is 1.22 g/cm 3 , the powder density had changed from 0.7 to 1.1 g/cm 3 depending on granule gauge.…”

“…We know that sorption activity is dependent on both the content and the chemical structure of the sorbent surface, as well as on their texture [2,3]. The most commonly encountered sorbents are those based on active carbons, aluminium oxides, silicon and carbon-mineral sorbents [4].…”

“…The most commonly encountered sorbents are those based on active carbons, aluminium oxides, silicon and carbon-mineral sorbents [4]. Carbon-mineral sorbents combine the activity of carbons and stability of mineral sorbents, the hydrophilic and hydrophobic nature of their surface, which make them compatible with bio-tissues [3]. Broadly speaking, sorbents come in diverse sizes of specific surfaces, which is measured based on pore size, where the larger the pore, the higher the specific surface of the sorbent.…”

“…The requirements for sorbents designated for use in medicine have been defined as follows: they need to be of adequate mechanical and chemical stability, comply with prescribed standardised granulometric and texture parameters, have certain chemical structure, cause as little damage to the biological tissue as possible and do not have a toxic effect on organs and tissue; that they do not absorb proteins and oxygen from the blood and lymph, that they do not disturb the body's mineral balance, that they are selective towards certain class of compounds, that they have optimal absorption capacity, that they remain active in all parts of the gastrointestinal tract and they can be thoroughly and well discharged from it [2,3]. Furthermore, it should to be pointed out that the development of sorption substances ought to be based on competitive, lowenergy, resource saving and environmentally friendly manufacturing technologies [5][6][7].…”