Medicinal and Pharmaceutical Applications of Seaweeds

El‐Sheekh, Mostafa M.; Fathy, Amr; Saber, Hani; Saber, Abdullah A.

doi:10.21608/ejbo.2022.145631.2022

Cited by 4 publications

(9 citation statements)

References 186 publications

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“…Seaweeds compounds possess several interesting biological activities, some of them are listed in Table 2. This thematic has been very well studied and there are various literature reviews based only in the seaweed potential bioactivities [1][2][3]5,15,16,22,28,35,[68][69][70][71][72][73][74][75][76][77][78]. Due to its being a developed thematic in various literature reviews, in this study, we will lightly explain the seaweed potential bioactivities.…”

Section: Potential Bioactivities Of Seaweedsmentioning

confidence: 95%

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From Ocean to Medicine: Harnessing Seaweed’s Potential for Drug Development

Cotas,

Lomartire,

Gonçalves

et al. 2024

IJMS

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Seaweed, a miscellaneous group of marine algae, has long been recognized for its rich nutritional composition and bioactive compounds, being considered nutraceutical ingredient. This revision delves into the promising role of seaweed-derived nutrients as a beneficial resource for drug discovery and innovative product development. Seaweeds are abundant sources of essential vitamins, minerals, polysaccharides, polyphenols, and unique secondary metabolites, which reveal a wide range of biological activities. These bioactive compounds possess potential therapeutic properties, making them intriguing candidates for drug leads in various medical applications and pharmaceutical drug development. It explores their pharmacological properties, including antioxidant, anti-inflammatory, antimicrobial, and anticancer activities, shedding light on their potential as therapeutic agents. Moreover, the manuscript provides insights into the development of formulation strategies and delivery systems to enhance the bioavailability and stability of seaweed-derived compounds. The manuscript also discusses the challenges and opportunities associated with the integration of seaweed-based nutrients into the pharmaceutical and nutraceutical industries. Regulatory considerations, sustainability, and scalability of sustainable seaweed sourcing and cultivation methods are addressed, emphasizing the need for a holistic approach in harnessing seaweed’s potential. This revision underscores the immense potential of seaweed-derived compounds as a valuable reservoir for drug leads and product development. By bridging the gap between marine biology, pharmacology, and product formulation, this research contributes to the critical advancement of sustainable and innovative solutions in the pharmaceutical and nutraceutical sectors.

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Section: Potential Bioactivities Of Seaweedsmentioning

confidence: 95%

“…There are compounds isolated from seaweed that have received little attention in the literature [33][34][35].…”

Section: Other Biomedical Compounds Of Interestmentioning

confidence: 99%

From Ocean to Medicine: Harnessing Seaweed’s Potential for Drug Development

Cotas,

Lomartire,

Gonçalves

et al. 2024

IJMS

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“…Algae, including cyanoprokaryotes, eukaryotic microalgae, and seaweeds, are a natural source of high-value bioactive constituents characterized by their immense biotechnological applications [6][7][8][9][10][11]. Given their potential antimicrobial effects against several pathogenic bacteria and fungi, they are currently utilized in different pharmaceutical industry trends and for medication improvement [9,12,13].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Bioactive Compounds Extracted from the Egyptian Untapped Green Alga Rhizoclonium hieroglyphicum

Morsi

El-Sabbagh

Mehesen³

et al. 2023

Water

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Finding alternative powerful antibacterial drugs of natural origins is, today, a crucial prerequisite due to the resistance of some bacterial strains to commercial and widely-used medications. Algae are characterized by their bioactive constituents and have a wide spectrum of biotechnological aspects, particularly antibacterial implications. During this study, four concentrations (5, 10, 20, and 40 mg mL–1) of the Egyptian untapped green microalga Rhizoclonium hieroglyphicum (Chlorophyta) were prepared using the polar solvents ethanol, methanol, and acetone. The antibacterial activity of the above-mentioned extracts was assessed, using the agar disc diffusion technique against three pathogenic bacteria, Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 8739, and Pseudomonas aeruginosa ATCC 9027, which was compared to standard antibiotics. The minimal inhibitory concentrations (MICs) were also assessed and determined using a broth dilution assay. Our findings revealed that the R. hieroglyphicum ethanolic extract exhibited the most potent antibacterial effect and its MICs values were 0.533, 2.25, and 5.34 mg mL–1 against P. aeruginosa, E. coli, and S. aureus, respectively. A gas chromatography–mass spectrometry (GC–MS) approach to the crude R. hieroglyphicum ethanolic extract uncovered 30 different bioactive constituents, mainly including long-chain polyunsaturated and saturated fatty acids such as myristic (C14:0), palmitic (C16:0), stearic (C18:0), α-linolenic (C18:3; ω–3), and oleic (C18:1, ω–9) acids, which synergistically make this potent antibacterial action. The mechanism of action of these fatty acids was also discussed. Conclusively, R. hieroglyphicum could be a good candidate for the production and development of promising antibacterial agents.

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“…Natural alginates are derived from the cell walls of brown seaweeds (Sachan et al 2009 ; El-Sheekh et al 2022 ). Among the different types of alginates, sodium alginate is the most utilized polysaccharide for pharmaceutical studies (Szekalska et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

“…Alginates are used in pharmaceutical industries due to their biocompatibility, biodegradability, immunogenicity, and non-toxicity (Rinaudo 2014 ; Leandro et al 2020 ). Given their potent anticancer and prebiotic effects, these valuable biopolymers are also used as food supplements (El-Sheekh et al 2022 ). Although the extraction and purification of sodium alginate are straightforward, it is a multistage process (Lee and Mooney 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Seaweed Sargassum aquifolium extract ameliorates cardiotoxicity induced by doxorubicin in rats

Samir

Hassan

Saber

et al. 2023

Environ Sci Pollut Res

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Doxorubicin (DOX) is a potent anticancer drug with adverse cardiotoxic effects. Alginates are multifunctional biopolymers and polyelectrolytes derived from the cell walls of brown seaweeds. They are nontoxic, biocompatible, and biodegradable, and hence, utilized in several biomedical and pharmaceutical applications. Here, we investigated the potential cardioprotective effect of thermally treated sodium alginate (TTSA), which was extracted and purified from the seaweed Sargassum aquifolium, in treating acute DOX cardiotoxicity and apoptotic pathways in rats. UV–visible spectroscopy, Fourier-transform infrared, and nuclear magnetic resonance (1H–NMR) spectroscopy techniques were used to characterize TTSA. CK-MB and AST levels in sera samples were determined. The expression levels of Erk-2 (MAPK-1) and iNOS genes were investigated by quantitative real-time polymerase chain reaction (qRT-PCR). The protein expression levels of Erk-2, anti-apoptotic p53, and caspase-3 were analyzed using western blotting and ELISA. For the in vivo studies, sixty rats were randomly divided equally into six groups and treated with DOX, followed by TTSA. We revealed that treatment with TTSA, which has low molecular weight and enhanced antioxidant properties, improved DOX-mediated cardiac dysfunction and alleviated DOX-induced myocardial apoptosis. Furthermore, TTSA exhibited a cardioprotective effect against DOX-induced cardiac toxicity, indicated by the increased expression of MAPK-1 (Erk2) and iNOS genes, which are implicated in the adaptive responses regulating DOX-induced myocardial damage. Moreover, TTSA significantly (p < 0.05) suppressed caspase-3 and upregulated anti-apoptotic protein p53 expression. TTSA also rebalanced the cardiomyocyte redox potential by significantly (p < 0.05) increasing the levels of endogenous antioxidant enzymes, including catalase and superoxide dismutase. Our findings suggest that TTSA, particularly at a dose of 400 mg/kg b.w., is a potential prophylactic supplement for treating acute DOX-linked cardiotoxicity.

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Medicinal and Pharmaceutical Applications of Seaweeds

Cited by 4 publications

References 186 publications

From Ocean to Medicine: Harnessing Seaweed’s Potential for Drug Development

From Ocean to Medicine: Harnessing Seaweed’s Potential for Drug Development

Antibacterial Activity of Bioactive Compounds Extracted from the Egyptian Untapped Green Alga Rhizoclonium hieroglyphicum

Seaweed Sargassum aquifolium extract ameliorates cardiotoxicity induced by doxorubicin in rats

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