Medicinal and Therapeutic Properties of Ephedra

Dousari, Amin Sadeghi; Satarzadeh, Naghmeh; Amirheidari, Bagher; Forootanfar, Hamid

doi:10.1007/s43450-022-00304-3

Cited by 13 publications

(7 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PDC, in addition to decarboxylation, also carries out carboligation reaction wherein it bridges a carbon bond from benzaldehyde into the active acetaldehyde resulting in the production of R– phenylacetylcarbinol (PAC), a major precursor involved in the manufacture of pharmaceuticals, namely, ephedrine and pseudoephedrine. Ephedrine and pseudoephedrine are used to prevent or relieve wheezing associated with asthma 29 , to relieve low blood pressure during spinal or epidural anaesthesia 30 , in the management and treatment of clinically significant hypotension 31 , act as a decongestant which reduces nasal congestion 32 . From the literature, it is also clear that ephedrine is a pharmaceutical drug to exhibit several adrenaline actions and it is used in the preparation of obesity management and sport medicine 33 .…”

Section: Introductionmentioning

confidence: 99%

Valorization of rice straw, sugarcane bagasse and sweet sorghum bagasse for the production of bioethanol and phenylacetylcarbinol

Nunta

Techapun

Sommanee

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Open burning of agricultural residues causes numerous complications including particulate matter pollution in the air, soil degradation, global warming and many more. Since they possess bio-conversion potential, agro-industrial residues including sugarcane bagasse (SCB), rice straw (RS), corncob (CC) and sweet sorghum bagasse (SSB) were chosen for the study. Yeast strains, Candida tropicalis, C. shehatae, Saccharomyces cerevisiae, and Kluyveromyces marxianus var. marxianus were compared for their production potential of bioethanol and phenylacetylcarbinol (PAC), an intermediate in the manufacture of crucial pharmaceuticals, namely, ephedrine, and pseudoephedrine. Among the substrates and yeasts evaluated, RS cultivated with C. tropicalis produced significantly (p ≤ 0.05) higher ethanol concentration at 15.3 g L−1 after 24 h cultivation. The product per substrate yield (Yeth/s) was 0.38 g g-1 with the volumetric productivity (Qp) of 0.64 g L−1 h−1 and fermentation efficiency of 73.6% based on a theoretical yield of 0.51 g ethanol/g glucose. C. tropicalis grown in RS medium produced 0.303 U mL−1 pyruvate decarboxylase (PDC), a key enzyme that catalyzes the production of PAC, with a specific activity of 0.400 U mg−1 protein after 24 h cultivation. This present study also compared the whole cells biomass of C. tropicalis with its partially purified PDC preparation for PAC biotransformation. The whole cells C. tropicalis PDC at 1.29 U mL−1 produced an overall concentration of 62.3 mM PAC, which was 68.4% higher when compared to partially purified enzyme preparation. The results suggest that the valorization of lignocellulosic residues into bioethanol and PAC will not only aid in mitigating the environmental challenge posed by their surroundings but also has the potential to improve the bioeconomy.

show abstract

Section: Introductionmentioning

confidence: 99%

Valorization of rice straw, sugarcane bagasse and sweet sorghum bagasse for the production of bioethanol and phenylacetylcarbinol

Nunta

Techapun

Sommanee

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…All annotations were matched by aligning precursor ion (MS1) and fragment ion (MS2) with the library. These matches were subsequently scrutinized using EH-related literature and standard substances [17,18,20,44,45].…”

Section: Characterization Of the Chemical Compounds In Eh Plasma And ...mentioning

confidence: 99%

“…Clinical analysis shows that EH has an extremely high frequency in some traditional Chinese medicine (TCM) formulae with a great clinical curative effect on the management and treatment of COVID-19, such as Qingfei Paidu decoction [12], Xuanfeibaidu formula [13], Huashi Baidu decoction [14], Jinhua Qinggan granules [15], and Lianhua Qingwen capsule/granules [16]. Modern pharmacological studies show that EH has central excitatory and analgesic effects, blood pressure regulation, antiviral activity, anti-inflammatory, anti-immune, and analgesic effects [17][18][19]. In addition, EH has been reported to contain a significant number of alkaloids, phenolic compounds (aromatic compounds, flavonoids, lignans, and proanthocyanidins), and organic acid and its derivative compounds [17,18].…”

Section: Introductionmentioning

confidence: 99%

A ternary correlation multi‐symptom network strategy based on in vivo chemical profile identification and metabolomics to explore the molecular basis of Ephedra herb against viral pneumonia

Wang,

Mei,

Zhang

et al. 2024

J of Separation Science

View full text Add to dashboard Cite

Ephedra herb (EH), an important medicine prescribed in herbal formulas by Traditional Chinese Medicine practitioners, has been widely used in the treatment of viral pneumonia in China. However, the molecular basis of EH in viral pneumonia remains unclear. In this study, a ternary correlation multi‐symptom network strategy was established based on in vivo chemical profile identification and metabolomics to explore the molecular basis of EH against viral pneumonia. Results showed that 143 compounds of EH and 70 prototype components were identified in vivo. EH could reduce alveolar‐capillary barrier disruption in rats with viral pneumonia and significantly downregulate the expression of inflammatory factors and bronchoalveolar lavage fluid. Plasma metabolomics revealed that EH may be involved in the regulation of arachidonic acid, tryptophan, tyrosine, nicotinate, and nicotinamide metabolism. The multi‐symptom network showed that 12 compounds have an integral function in the treatment of viral pneumonia by intervening in many pathways related to viruses, immunity and inflammation, and lung injury. Further verification demonstrated that sinapic acid and frambinone can regulate the expression of related genes. It has been shown to be a promising representative of the pharmacological constituents of ephedra.

show abstract

“…1,2) Ephedra herbs have been used as an important medicine for the treatment of asthma, fever, and nasal congestion. 2,3) The major ingredients contained in Ephedra plants are ephedrine alkaloids (EAs), such as ephedrine (Ep) and pseudoephedrine (PEp), which accumulate in herbal stems. The amounts of EAs in Ephedra are one of the criteria for medicinal usage in the Japanese Pharmacopoeia 18th edition (JP18).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Non-ephedrine Constituents from <i>Ephedra</i> Plants Cultivated in Japan

Hayashi,

Miyao,

Matsui

et al. 2024

Chem. Pharm. Bull.

View full text Add to dashboard Cite

Ephedra plants, the main components of which are ephedrine alkaloids, are used as traditional medicines in Eastern Asian countries. In this study, we isolated non-ephedrine constituents from various Ephedra plant species cultivated in Japan. HPLC analysis suggested that kynurenic acid and its derivatives accumulated in a wide range of Ephedra plant species. Furthermore, a large amount of (2R,3S)-O-benzoyl isocitrate has been isolated from E. intermedia. This study suggests that Ephedra plants have diverse non-ephedrine constituents.

show abstract

Medicinal and Therapeutic Properties of Ephedra

Cited by 13 publications

References 115 publications

Valorization of rice straw, sugarcane bagasse and sweet sorghum bagasse for the production of bioethanol and phenylacetylcarbinol

Valorization of rice straw, sugarcane bagasse and sweet sorghum bagasse for the production of bioethanol and phenylacetylcarbinol

A ternary correlation multi‐symptom network strategy based on in vivo chemical profile identification and metabolomics to explore the molecular basis of Ephedra herb against viral pneumonia

Comparison of Non-ephedrine Constituents from <i>Ephedra</i> Plants Cultivated in Japan

Contact Info

Product

Resources

About