Medicinal Applications of Coordination Complexes

Abstract

Coordination compounds and organometallics have very special place in chemistry due to their different structural arrangements and application in various fields. They also play vital role in biological system particularly in human and plant life. The blood oxygen carrier haemoglobin is a coordination compound of iron which is essential for human life, also the chlorophyll is a coordination compound of magnesium essential for plant the life and the continuation of the life on this planet. These compounds are not only biologically important but also comprise a group of drug like molecules and medicines. Coordination compounds such as platinum, palladium and ruthenium complexes are anti-cancer drugs. Also, many of the coordination compounds are anti-bacterial. The coordination compounds have been showed effective behaviour against many diseases like Alzheimer’s and malaria. Recently coordination compounds used as antivirus such as coronavirus. In present review, we highlighted the most important coordination complexes that show a significant role in the field of medicine.

Synthesis, Characterization, Antimicrobial and Antifungal Activities of Mn(II) and Zn(II) Complexes with Azo Dye of 2-aminobenzimidazole and Indole

“…The UV-vis spectra of BIAI ligand and its complexes were Many azo dyes possessing heterocyclic rings and their complexes displayed a tall development hindrance against numerous microbes and fungi. [16][17][18] Therefore, we were fascinated by identifying the impact of BIAI ligand and its chelate complexes of Mn (II) and Zn(II) on two sort of microbes, S. aureus (positive gram) and E. coli (negative gram) and A. niger as a sort of fungi. The antimicrobial inhibition of BIAI ligand and its complexes against bacteria organisms are recorded in Table 3.…”

Synthesis, Identification, and Biological Study for Some Complexes of Azo Dye Having Theophylline

“…e CPAT dye showed absorption bands at 280 nm and 350 nm due to π-π * transition and at 450 nm due to n-π * transition. Nickel (II) complex of CPAT dye exhibited absorption bands at 343 nm due to π-π * transition, 471 nm due to 3 A 2g (F) to 3 T 2g (F) transition, 620 nm due to 3 A 2g (F) to 3 T 1g (F) transition, and 717 nm due to 3 A 2g (F) to 3 T 2g (P) transition, with a magnetic moment equal to 3.21 B M in agreement with octahedral nickel complexes [36]. Cobalt(II) complex of CPAT dye showed absorption bands at 350 nm due to π-π * transition, 470 nm due to 4 T 1g (F) to 4 T 2 g(P) transition, 580 nm due to 4 T 1g (F) to 4 A 2g (F) transition, and 705 nm due to 4 T 1g (F) to 4 T 2g (F) transition with magnetic moment equal to 5.01 B.M.…”

“…e azo function (-N�N-) in the ligands appears intense color within the visible area and is sensitive for the changes in the acidity (pH) that leads to the use of the ligands of this function as colorant for the tissue and indicators in analytical chemistry [1][2][3][4]. Azo dyes exhibit stereoisomerism under the light.…”

Syntheses and structural characterization of divalent metal complexes (Co, Ni, Pd and Zn) of sterically hindered thiourea ligand and a theoretical insight of their interaction with SARS-CoV-2 enzyme

“…Since, thiourea is widely used in pharmaceutical industry, its selection as a ligand poses no questions. Cobalt, nickel, zinc and palladium complexes have received special attention in bioinorganic applications due to their binding ability to human proteins [26] .…”