Medicinal bismuth: Bismuth-organic frameworks as pharmaceutically privileged compounds

Shetu, Shaila A.; Sanchez-Palestino, Luis M.; Rivera, Gildardo; Bandyopadhyay, Debasish

doi:10.1016/j.tet.2022.133117

Cited by 13 publications

(10 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bismuth has an extensive history of medicinal use and applications in medicine and healthcare, including treating gastrointestinal disorders, antitumor activities, and antimicrobial and antibacterial properties [40]. In this context, Bi-MOFs have been obtained in the last decade with potential applications in bacterial eradication.…”

Section: Introductionmentioning

confidence: 99%

Advances in Nanomaterials and Composites Based on Mesoporous Materials as Antimicrobial Agents: Relevant Applications in Human Health

Gomez,

Hamer,

Regiart

et al. 2024

Antibiotics

View full text Add to dashboard Cite

Nanotechnology has emerged as a cornerstone in contemporary research, marked by the advent of advanced technologies aimed at nanoengineering materials with diverse applications, particularly to address challenges in human health. Among these challenges, antimicrobial resistance (AMR) has risen as a significant and pressing threat to public health, creating obstacles in preventing and treating persistent diseases. Despite efforts in recent decades to combat AMR, global trends indicate an ongoing and concerning increase in AMR. The primary contributors to the escalation of AMR are the misuse and overuse of various antimicrobial agents in healthcare settings. This has led to severe consequences not only in terms of compromised treatment outcomes but also in terms of substantial financial burdens. The economic impact of AMR is reflected in skyrocketing healthcare costs attributed to heightened hospital admissions and increased drug usage. To address this critical issue, it is imperative to implement effective strategies for antimicrobial therapies. This comprehensive review will explore the latest scientific breakthroughs within the metal–organic frameworks and the use of mesoporous metallic oxide derivates as antimicrobial agents. We will explore their biomedical applications in human health, shedding light on promising avenues for combating AMR. Finally, we will conclude the current state of research and offer perspectives on the future development of these nanomaterials in the ongoing battle against AMR.

show abstract

Section: Introductionmentioning

confidence: 99%

Advances in Nanomaterials and Composites Based on Mesoporous Materials as Antimicrobial Agents: Relevant Applications in Human Health

Gomez,

Hamer,

Regiart

et al. 2024

Antibiotics

View full text Add to dashboard Cite

show abstract

“…28 In addition to antibacterial activity, bismuth compounds have also shown anticancer, antileishmaniasis, and to a certain extent antifungal and other medicinal properties. 29 Some bismuth compounds derived from tropolone, thiosemicarbazones, or sulfapyridine and dithiocarbamate, have been found to be prominent antitumor activities. 30 The cytotoxic mechanism of some bismuth compounds is related to the induction of tumor cell apoptosis 31,32 and the inhibition of enzymes such as protease, lipase, glycosidase, and phospholipase.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the safety of these bismuth preparations is excellent 28 . In addition to antibacterial activity, bismuth compounds have also shown anticancer, antileishmaniasis, and to a certain extent antifungal and other medicinal properties 29 . Some bismuth compounds derived from tropolone, thiosemicarbazones, or sulfapyridine and dithiocarbamate, have been found to be prominent antitumor activities 30 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, and in vitro biological evaluation of bismuth (III) complexes incorporating pyrazinohydrazide‐derived Schiff bases

Li,

Qiu,

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

Two new Schiff‐base bismuth (III) complexes were prepared by an equivalent reaction between Schiff‐base ligand and Bi (NO3)3•5H2O with the assistance of Mannitol. The chemical structures of the two complexes were characterized by spectroscopic studies (FT‐IR, NMR, and MS), elemental analysis, and single‐crystal X‐ray diffraction. The ligand‐to‐metal ion ratio was found to be 1:1 in the complexes. During the formation of the complexes, Schiff bases changed from the amidic forms to the iminol forms, and the resulting tautomers could coordinate with bismuth (III) ions to produce dinuclear BiIII complexes(1a and 2a). Structural analyses showed that each Bi (III) ion held a distorted capped octahedron geometry with a seven‐coordinate mode in two complexes. Screening in vitro biological activities revealed that two bismuth (III) complexes exhibited much higher antimicrobial and cytotoxic activity than their parent ligands. The cytotoxic activity of the complex(1a) was close to that of the known anticancer drug (Doxorubicin) by evaluating against SGC7901 cells, with the IC50 value 0.59 μM. The complex(1a) could effectively induce SGC7901 cell apoptosis and its oral acute toxicity for LD50 value was found to be 576 mg kg−1. The content of bismuth (III) in mitochondria was higher than that in the nucleus.

show abstract

“…Of particular interest is the evaluation of metal halide materials as antibacterial agents, an emerging and quite impactful application . Apparently, hybrid metal complexes offer significant advantages over fully organic or fully inorganic compounds. , Antimicrobial resistance (AMR) is identified by the World Health Organization (WHO) as one of the greatest threats humanity faces, and this problem is expected to deteriorate over the following decades. , Despite advances in antibiotic development, the rapid rates at which bacteria develop resistance are alarming. Therefore, there is immense interest in the scientific community in developing next-generation drug candidates with improved antibacterial efficiency, efficacy, and selectivity. − …”

Section: Introductionmentioning

confidence: 99%

“…22 Apparently, hybrid metal complexes offer significant advantages over fully organic or fully inorganic compounds. 23,24 Antimicrobial resistance (AMR) is identified by the World Health Organization (WHO) as one of the greatest threats humanity faces, and this problem is expected to deteriorate over the following decades. 25,26 Despite advances in antibiotic development, the rapid rates at which bacteria develop resistance are alarming.…”

Section: ■ Introductionmentioning

confidence: 99%

One-Year Water-Stable and Porous Bi(III) Halide Semiconductor with Broad-Spectrum Antibacterial Performance

Azmy,

Zhao,

Angeli

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Medicinal bismuth: Bismuth-organic frameworks as pharmaceutically privileged compounds

Cited by 13 publications

References 99 publications

Advances in Nanomaterials and Composites Based on Mesoporous Materials as Antimicrobial Agents: Relevant Applications in Human Health

Advances in Nanomaterials and Composites Based on Mesoporous Materials as Antimicrobial Agents: Relevant Applications in Human Health

Synthesis, crystal structure, and in vitro biological evaluation of bismuth (III) complexes incorporating pyrazinohydrazide‐derived Schiff bases

One-Year Water-Stable and Porous Bi(III) Halide Semiconductor with Broad-Spectrum Antibacterial Performance

Contact Info

Product

Resources

About