2007
DOI: 10.5688/aj7106123
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Medicinal Chemistry and Therapeutic Relevance of Angiotensin-Converting Enzyme Inhibitors

Abstract: Chemical Basis of Drug Action (PHA337 and PHA447) is a required 2-semester course sequence taught to second-professional year pharmacy students at Creighton University in both the campus and distance-education pathways. The course emphasizes integration of previous content, critical thinking, and therapeutic relevance. The content and learning experiences are organized to transition the students' thinking through a constructive process that provides ample opportunities to recall and integrate previous knowledg… Show more

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Cited by 11 publications
(3 citation statements)
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“…Due to its unique cyclic structure, proline is critical in biological recognition and structural motifs in a wide array of therapeutics, and has frequently been explored as a template and starting point for derivation of peptidic leads [28]. For instance, proline-mimetics as well as substituted prolines in inhibitors targeting angiotensin-converting enzyme [29] and hepatitis C NS3 protease [30] have successfully advanced into the clinic. In a continuing effort to develop more potent and selective antichlamydial drugs, herein, two generations of proline-based amino acid analogues were developed from the newer lead compound 2 [25] (with improved antiCtHtrA activity over 1) by proline ring expansion in the conserved tripeptidic structure as well as extended substitutions at Cγ position of proline with a diverse range of functional groups (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…Due to its unique cyclic structure, proline is critical in biological recognition and structural motifs in a wide array of therapeutics, and has frequently been explored as a template and starting point for derivation of peptidic leads [28]. For instance, proline-mimetics as well as substituted prolines in inhibitors targeting angiotensin-converting enzyme [29] and hepatitis C NS3 protease [30] have successfully advanced into the clinic. In a continuing effort to develop more potent and selective antichlamydial drugs, herein, two generations of proline-based amino acid analogues were developed from the newer lead compound 2 [25] (with improved antiCtHtrA activity over 1) by proline ring expansion in the conserved tripeptidic structure as well as extended substitutions at Cγ position of proline with a diverse range of functional groups (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…To assist students in grasping medicinal chemistry concepts, a variety of interactive and active learning measures have been developed by medicinal chemistry faculty in addition to traditional classroom lectures. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] A thorough understanding of the chemical basis of drug action allows pharmacy students to recommend safer and more effective alternative agents, identify potential drug-drug interactions, rationalize the basis for clinical recommendations, and ultimately solve clinical problems in order to improve patient care.…”
Section: Introductionmentioning
confidence: 99%
“…The medicinal chemistry of particular drug classes, including antihyperlipidemics and angiotensin converting enzyme inhibitors, was taught using various learning methods and strategies designed to aid students in quickly identifying the most critical aspects of the particular drug class and practicing required critical-thinking and analysis skills. 11,12 Various medicinal chemistry teaching examples were also published, including the use of a "Who Wants to be a Medicinal Chemistry Millionaire" learning game to reinforce the importance of chemistry to pharmacy practice, 13 a model to enhance the knowledge and ability of pharmacy students to better predict the acidbase reactivity and degree of ionization and to convey better understanding of drug actions in vivo and in vitro, 14 and the use of crossword puzzles as educational aids to enhance pharmacy student learning of anti-ulcer drugs. 15 The current study presents a novel approach that used experimental, chemical, and spectral visual approaches to improve students' learning of antibiotic stability and interactions with food and drugs, with the goal of highlighting the clinical relevance of medicinal chemistry.…”
Section: Introductionmentioning
confidence: 99%