Medicinal gold compounds

Abstract

A major use of gold compounds in the pharmaceutical industry is for antiarthritic agents. The disease itself is not understood and little is known about the way in which the drugs act, but detailed pictures of the distribution of gold in the body are available, and some of the relevant biochemistry is beginning to emerge.

Chloro(triethylphosphine)gold(I)

“…1, which was drawn with OR TEPII (Johnson, 1971) at 15% probability ellipsoids. Berners-Price & Sadler, 1987;Parish & Cottrill, 1987). Et3PAuC1 , which is known to interact with DNA (Mirabelli, Sung, Zimmerman, Hill, Mong & Crooke, 1986), has a similar coordination geometry to that reported for the triphenylphosphine analogue PhaPAuC1 (Baenziger, Bennett & Soboroff, 1976 …”

Synthesis and antimicrobial activities of gold(I) sulfanylcarboxylates

“…Studies on gold complexes have mainly focused on antiarthritic properties [16][17][18][19][20][21], but growing interest is evident in antitumoral [22][23][24], antiparasitic [25] and antibacterial activities. In this last field, the compounds under investigation include a major collection of the type R 3 PAuL, in which the gold atom is coordinated to a phosphine ligand and L is an O- [26,27], N- [28,29], Cl- [30] or S- [29,[31][32][33][34][35] 2 ], Na 3 [Au(mna) 2 ] (H 2 mna 02-mercaptonicotinic acid) [13] and the cationic complexes [Au(L) 2 ](NO 3 ) 3 (L01-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea) [34].…”

HIV therapeutic possibilities of gold compounds

“…The limitation of gold(III) compounds for use in drug development stems from the fact that gold(III) compounds tend to be thermally unstable and are reduced in physiological conditions. Gold(III) also tends to be toxic (Parish and Cottrill 1987). Nevertheless, a few gold(III) compounds have been reported to inhibit HIV.…”