Medicinal natural products in osteoporosis

Şöhretoğlu, Didem; Renda, Gülin

doi:10.1016/bs.armc.2020.03.002

Cited by 6 publications

(5 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to mineral elements, this plant is a good source of polyphenolic compounds, including isoflavonoids and flavonoids (Saqib et al, 2022). Studies have shown that isoflavonoids such as genistein, daidzein, and biochanin A, along with flavonoids such as quercetin and kaempferol, can be effective in reabsorbing calcium, stimulating osteoblast activation pathways, and inhibiting osteoclast activity through different pathways (Şöhretoğlu & Renda, 2020). Ma et al (2011) showed that genistein can stimulate the differentiation and mineralization of osteoblasts by increasing the expression of BMP-2 and RUNX-2 in in vitro and in vivo models in rat’s frontal and parietal bones (Ma et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Panicum miliaceum L. and Bone Healing Properties in Rat Model of Femur Fracture by Activating Phosphate Stimulating Macrophages via BMP2 and RANK Signaling Pathway

Zhang,

Wang,

Pan

et al. 2023

Pharmacognosy Magazine

View full text Add to dashboard Cite

Objective The aim of this study was to investigate the effect of Panicum miliaceum involved in the repair of femur bone fracture in rats. Materials and Methods In this study, 40 Wistar rats in five groups were studied as healthy, rats with lesion induced by surgery in femur (FX), FX rats treated with P. miliaceum extract (FX +100 and 200 P. miliaceum) and FX rats treated with Osteocare syrup (FX + OC). After 40 days, the serum levels of blood calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP) along with activity of glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) enzymes, and nitric oxide (NO) level were measured. The serum level of cytokines (IL-6, C-reactive protein [CRP], IL-10, IL-1β, and tumor necrosis factor-α [TNF-α]) was also measured by ELISA. The expression of OPG, RANK, RANKL, and BMP-2 genes and proteins were evaluated by real-time PCR and Western blotting techniques, respectively. Results The results showed that P. miliaceum was able to decrease the activity of ALP enzyme in addition to increasing serum Ca and P levels and GPx, SOD, and CAT activity. P. miliaceum reduces serum IL-6, IL-1β, and TNF-α, and NO levels. Also, the extract of this plant could increase the expression of OPG/RANK/BMP-2 pathway genes and proteins. Conclusions P. miliaceum can be used as a prodrug in traditional medicine to repair bone fractures and osteoporosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Panicum miliaceum L. and Bone Healing Properties in Rat Model of Femur Fracture by Activating Phosphate Stimulating Macrophages via BMP2 and RANK Signaling Pathway

Zhang,

Wang,

Pan

et al. 2023

Pharmacognosy Magazine

View full text Add to dashboard Cite

show abstract

“…Daidzein can prevent bone loss and cisplatin‐induced cell apoptosis (Şöhretoğlu & Renda, 2020), also plays an important role in isoflavone biosynthesis. Daidzein can be synthesized from liquiritigenin via 2‐hydroxyisoflavanone synthase (2‐HIS) from Glycyrrhiza echinata and 2‐hydroxyisoflavanone dehydratase (HID) from Glycine max (Q. Liu, Liu, et al, 2021).…”

Section: P‐coumaric Acid Derivativesmentioning

confidence: 99%

Yeast: A platform for the production of _L‐tyrosine derivatives

Guo

et al. 2023

Yeast

View full text Add to dashboard Cite

L -Tyrosine derivatives are widely applied in the pharmaceutical, food, and chemical industries. Their production is mainly confined to chemical synthesis and plant extract. Microorganisms, as cell factories, exhibit promising advantages for valuable chemical production to fulfill the increase in the demand of global markets. Yeast has been used to produce natural products owing to its robustness and genetic maneuverability. Focusing on the progress of yeast cell factories for the production of L -tyrosine derivatives, we summarized the emerging metabolic engineering approaches in building L -tyrosoineoverproducing yeast and constructing cell factories of three typical chemicals and their derivatives: tyrosol, p-coumaric acid, and L -DOPA. Finally, the challenges and opportunities of L -tyrosine derivatives production in yeast cell factories were also discussed.aromatic amino acids, cell factory, L -tyrosine derivatives, synthetic biology, yeastis an essential amino acid nutrient with diverse applications in food, medicine, and chemical industries. Its derivatives, including Hydroxytyrosol S. cerevisiae Glucose 5L fed-batch 6970 H. Liu, Wu, et al. (2022) Salidroside S. cerevisiae Glucose 5L fed-batch 26,550 H. Liu, Tian, et al. (2021) p-Coumaric acid derivatives p-coumaric acid S. cerevisiae Glucose 1L fed-batch 12,500 Q. Liu, Yu, et al. (2019) p-coumaric acid S. cerevisiae Xylose 1L fed-batch 242 Borja et al. (2019) Caffeic acid S. cerevisiae Carboxymethylcellulose Shake flask 16.91 M. Cai et al. (2022) Caffeic acid S. cerevisiae Glucose 1.2L fed-batch 5500 R. Chen et al. (2022) Caffeic acid Candida glycerinogenes Glucose and Xylose 5L fed-batch 431.45 X.-H. Wang et al. (2022) Rosmarinic acid S. cerevisiae Glucose Shake flask 208 P. Zhou et al. (2022) Ferulic Acid S. cerevisiae Glucose 1.2L fed-batch 3800 R. Chen et al. (2022) Resveratrol S. cerevisiae Glucose and Ethanol shake flask 187 Costa et al. (2021) Resveratrol S. cerevisiae Lactose Shake flask 210 Costa et al. (2022) Resveratrol Scheffersomyces stipitis Cellobiose Shake flask 529.8 Kobayashi et al. (2021) Resveratrol S. stipitis Sucrose Shake flask 668.6 Kobayashi et al. (2021) Resveratrol Pichia pastoris Glycerol 250 mL fed-batch 1825 Kumokita et al. (2022) Pterostilbene S. cerevisiae Glucose Shake flask 34.93 M. Li et al. (2016) Pinostilbene S. cerevisiae Glucose Shake flask 5.52 M. Li et al. (2016) Naringenin S. cerevisiae Glucose Shake flask 203.49 Tong et al. (2022) Naringenin S. cerevisiae Glucose 5L fed-batch 1184.1 H. Li et al. (2022) Naringenin Yarrowia lipolytica Glucose 3L fed-batch 898 Palmer et al. (2020) Naringenin P. pastoris Glycerol 250 mL fed-batch 1067 Kumokita et al. (2022) Naringenin Y. lipolytica Glucose Shake flask 252.4 Lv et al. (2019) Eriodictyol Y. lipolytica Glucose Shake flask 134.2 Lv et al. (2019) Phloretin S. cerevisiae Glucose 5L fed-batch 619.5 C. Jiang et al. (2020) Apigenin Y. lipolytica Glucose Shake flask 80.74 Vanegas et al. (2018) Luteolin Y. lipolytica Glucose Shake flask 47.9 Vanegas et al. (2018) Kaempferol S. ...

show abstract

“…However, this treatment is not effective for osteoporosis. Nowadays, the focus of the investigations is a more effective alternative system of medicine on osteoporosis with less side effects1 7 , 18 . Furthermore, more research to reduce the osteoporotic bone loss is needed.…”

Section: Introductionmentioning

confidence: 99%

Antiosteoporosis effect of bryodulcosigenin on ovariectomy-induced osteoporosis in experimental rats

Sun,

Qin

2024

Acta Cir Bras

View full text Add to dashboard Cite

Purpose: Osteoporosis is a bone disease which commonly occurred in postmenopausal women. Almost 10 percent of world population and approximately 30% of women (postmenopausal) suffer from this disease. Alternative medicine has great success in the treatment of osteoporosis disease. Bryodulcosigenin, a potent phytoconstituent, already displayed the anti-inflammatory and antioxidant effect. In this study, we made effort to analyze the antiosteoporosis effect of bryodulcosigenin against ovariectomy (OVX) induced osteoporosis in rats. Methods: Swiss albino Wistar rats were grouped into fIve groups and given an oral dose of bryodulcosigenin (10, 20 and 30 mg/kg) for eight weeks. Body weight, uterus, bone mineral density, cytokines, hormones parameters, transforming growth factor (TGF)-β, insulin-like growth factor (IGF), osteoprotegerin (OPG), receptor activator of nuclear factor kappa-Β ligand (RANKL), and its ratio were estimated. Results: Bryodulcosigenin significantly (p < 0.001) suppressed the body weight and enhanced the uterine weight and significantly (p < 0.001) increased the bone mineral density in whole femur, caput femoris, distal femur and proximal femur. Bryodulcosigenin significantly (P < 0.001) altered the level of biochemical parameters at dose dependent manner, significantly (P < 0.001) improved the level of estrogen and suppressed the level of follicle stimulating hormone and luteinizing hormone. Bryodulcosigenin significantly (P < 0.001) improved the level of OPG and suppressed the level of RANKL. Conclusions: Bryodulcosigenin reduced the cytokines level and suppressed the TGF-β and IGF. We concluded that bryodulcosigenin is an antiosteoporosis medication based on the findings.

show abstract

Medicinal natural products in osteoporosis

Cited by 6 publications

References 132 publications

Panicum miliaceum L. and Bone Healing Properties in Rat Model of Femur Fracture by Activating Phosphate Stimulating Macrophages via BMP2 and RANK Signaling Pathway

Panicum miliaceum L. and Bone Healing Properties in Rat Model of Femur Fracture by Activating Phosphate Stimulating Macrophages via BMP2 and RANK Signaling Pathway

Yeast: A platform for the production of _L‐tyrosine derivatives

Antiosteoporosis effect of bryodulcosigenin on ovariectomy-induced osteoporosis in experimental rats

Contact Info

Product

Resources

About

Medicinal natural products in osteoporosis

Cited by 6 publications

References 132 publications

Panicum miliaceum L. and Bone Healing Properties in Rat Model of Femur Fracture by Activating Phosphate Stimulating Macrophages via BMP2 and RANK Signaling Pathway

Panicum miliaceum L. and Bone Healing Properties in Rat Model of Femur Fracture by Activating Phosphate Stimulating Macrophages via BMP2 and RANK Signaling Pathway

Yeast: A platform for the production of L‐tyrosine derivatives

Antiosteoporosis effect of bryodulcosigenin on ovariectomy-induced osteoporosis in experimental rats

Contact Info

Product

Resources

About

Yeast: A platform for the production of _L‐tyrosine derivatives