Medicinal plant species used in the treatment of skin diseases in Katabi Subcounty, Wakiso District, Uganda

Tugume, Patience; Nambejja, Cissy; Nyakoojo, Clement; Kamatenesi‐Mugisha, Maud

doi:10.32859/era.18.20.1-17

Cited by 17 publications

(19 citation statements)

References 22 publications

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“…27 It has a wide folkloric use against diverse diseases. More importantly, it has gained wide application in the management of wound, [28][29][30][31][32][33] and other medicinal uses such as relieve of headache, 34 antiplasmodial, [35][36][37][38][39] antibacterial, 34,40,41 diarrheal disease, [42][43][44][45] snake bite poison, [46][47][48][49] cataract, 40,50 toothache, 44 placenta removal, 33,51,52 skin cut/infection, [53][54][55] dermatitis, 56 febrile convulsion, 57 anti-trypanosomal, 33 endo/ ectoparasite, 58,59 cancer or tumour, 60 and eye infection and warts. 61 The volatile oil from the leaf, crude extracts, fractions, and isolated pure compounds were tested in vitro to evaluate antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

Lambebo¹,

Kifle²,

Gurji³

et al. 2021

JEP

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Background Medicinal plants play an important role in treating various diseases. Vernonia auriculifera Hiern is one of the medicinal plants used traditionally for the management of wounds. However, there were no scientific reports documented so far on the wound healing activities to substantiate the claim. Thus, the present study provides a scientific evaluation for the wound healing potential of the crude extract as well as solvent fractions of the leaves of Vernonia auriculifera Hiern. Methods Extraction was carried out by maceration using 80% methanol and part of the crude extract fractionated with chloroform, ethyl acetate, and aqueous solvents. Simple ointment bases were prepared using hard paraffin, cetostearyl alcohol, white soft paraffin and wool fat according to British Pharmacopoeia. Then, two types of ointment formulations were prepared from the extract, ie, 5% w/w and 10% w/w. Mice and rats were employed for wound healing study and dermal toxicity test, respectively. Wound healing effects were evaluated by percent of wound contraction, period of epithelialization, tensile strength, and histological analysis as parameters in excision, incision, and burn wound models. Finally, the data were expressed as mean ± SEM, and the results were analyzed using one-way ANOVA followed by post hoc Tukey-test. Results In the excision wound model, the 10% w/w crude extract ointment showed significant wound contraction ( P < 0.001) from day 4 to day 18 as compared to the negative control. Both the 5% w/w ( P < 0.001) and 10% w/w ( P < 0.05) crude extract ointments have showed statistically significant difference in epithelialization period as compared to the negative control. Groups treated with the ethyl acetate and aqueous fractions ointments in incision wound model showed a statistically significant ( P < 0.001) increase in tensile. The 10% w/w and 5% w/w ointments of the crude extract showed a significant ( P < 0.001) increase in breaking strength compared to simple ointment and the untreated control groups. In burn wound model, significant reduction in epithelialization period was observed in 5% w/w ( P < 0.05) and 10% w/w ( P < 0.001), and the percentage of wound contraction was significantly increased in most of post wounding days by 10% w/w ( P < 0.001) and 5% w/w ( P < 0.05) crude extract ointments and compared to the negative control. Conclusion The crude, aqueous, and ethyl acetate fraction of Vernonia auriculifera leaves possess wound healing activities. This finding justifies the use of the leaves of this plant for wound healing as claimed in the traditional medicine literature.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

Lambebo¹,

Kifle²,

Gurji³

et al. 2021

JEP

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“…Two more studies from Mpigi district identified the stem bark and the leaves for treatment of HIV/AIDS and related medical disorders [ 17 , 58 ]. At another study site in Uganda, Katabi subcounty in Wakiso district, the leaves and the bark were used in treatment of wounds and skin rashes [ 97 ]. In Kakamega county, Kenya, the bark and the leaves were reported to be used in treatment of breast, uterine, and skin cancer [ 98 ].…”

Section: Resultsmentioning

confidence: 99%

A Bibliographic Assessment Using the Degrees of Publication Method: Medicinal Plants from the Rural Greater Mpigi Region (Uganda)

Schultz

Anywar

Quave

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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In ethnopharmacological research, many field assessment tools exist. Yet, these miss that critical point of how to really determine which species merit the costly lab studies, e.g., evaluation of traditional use via pharmacological assays and isolation of bioactive secondary metabolites. This gap can be filled with the introduction of a new tool for literature assessment: the Degrees of Publication (DoPs). In this study, its application is illustrated through an extensive bibliographic assessment of 16 medicinal plant species that were recently identified in the Greater Mpigi region of Uganda as being frequently used by local traditional healers in the treatment of medical disorders (namely, Albizia coriaria, Cassine buchananii, Combretum molle, Erythrina abyssinica, Ficus saussureana, Harungana madagascariensis, Leucas calostachys, Microgramma lycopodioides, Morella kandtiana, Plectranthus hadiensis, Securidaca longipedunculata, Sesamum calycinum subsp. angustifolium, Solanum aculeastrum, Toddalia asiatica, Warburgia ugandensis, and Zanthoxylum chalybeum). These species are suspected to be understudied, and a thorough bibliographic assessment has not been previously performed. Thus, the objectives of our study were to undertake a comparative assessment of the degree to which each of these plant species has been studied in the past, including evaluation of the quality of the journals where results were published in. The determination of the DoPs enabled successful assessment of the degrees to which each individual plant species has been studied so far, while also taking into account the methodological “research chain of ethnopharmacology” from ethnobotanical studies (“traditional use”) to pharmacological assays (“bioactivity”) and finally to pharmacognostic research (“structure elucidation”). The significance of a research paper was assessed by determining whether its journal and publishing house were members of the Committee on Publication Ethics (COPE). In total, 634 peer-reviewed publications were reviewed covering the period of 1960–2019, 53.3% of which were published in journals and by publishing houses affiliated with COPE (338 publications). The literature assessment resulted in the identification of understudied plants among the selected species. The majority of plants reviewed have not been sufficiently studied; six species were classified as being highly understudied and three more as being understudied: C. buchananii, F. saussureana, L. calostachys, M. lycopodioides, M. kandtiana, and S. calycinum subsp. angustifolium and A. coriaria, P. hadiensis, and S. aculeastrum, respectively. The newly introduced DoPs are a useful tool for the selection of traditionally used species for future laboratory studies, especially for pharmacological bioassays, isolation procedures, and drug discovery strategies.

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“…People usually choose the herbal products instead of medical drugs [46]. The use of medical plant species in the treatment of children diseases is a part of traditional knowledge that is handed down by hearsay advices [20].…”

Section: Discussionmentioning

confidence: 99%

“…It is predicted that this rate will be greater for the COVID-19 pandemic process. WHO has been reported nearly ~80% of the world's population uses and trust herbal products for treatment [17][18][19][20].…”

Section: Prevalence Of Herbal Medicinal Product Usementioning

confidence: 99%

Safety of Herbal Medicines in Children

Polat¹,

Gürol²

2021

Alternative Medicine - Update

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Herbal medicine is used by individuals of all ages, including children. Herbal medicine includes herbs, herbal materials and preparations, and finished herbal products. Herbal medicine or herbal products’ use for all ages have increased in recent years. Based on the data of the World Health Organization, almost 80% of the population in developing countries trust herbal medicines to meet their health needs. Herbal medicines use unconsciously as though these products are harmless. The use of herbal products in children is a concern because little information is available concerning the benefits and risks of these products in the pediatric population. This creates a serious problem in the treatment of children, and reveals a serious and under-recognized hazard in clinical care. The safety of most herbal medicinal products is absent since lack of suitable quality controls and not available of appropriate patient information. Owing to the possibility of serious health complications arising from the use of herbal products, it is mandatory to understand their use in the general population in order for appropriate measures to be put into place.

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Medicinal plant species used in the treatment of skin diseases in Katabi Subcounty, Wakiso District, Uganda

Cited by 17 publications

References 22 publications

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice

A Bibliographic Assessment Using the Degrees of Publication Method: Medicinal Plants from the Rural Greater Mpigi Region (Uganda)

Safety of Herbal Medicines in Children

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