Medicinal Plant Used Against Cancer: A Review

Srivastava, Rajat; Tiwari, Priya

doi:10.22270/ajprd.v10i4.1150

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…It is expected that around 21.7 million people will be diagnosed with tumors by 2030, among these 13 million being in their terminal stage of cancer (Edge et al 2010). Many lifestyle difficulties, including smoking, physical inactivity, poor diet, and low pregnancies, contribute to cancer risks, particularly in the American cancer community's developing countries (Srivastava and Tiwari. 2022).…”

Section: Figure 1 Common Causes Of Breast Cancer 2 Classification Of ...mentioning

confidence: 99%

The use of medicinal plants for combating breast cancer: A comprehensive review

Alsubhi

2023

J Exp Bio & Ag Sci

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Breast carcinoma is a common illness among females. Various therapies, including hormone therapy, surgery, radiotherapy, chemotherapy, and targeted treatment, have been available to treat existing breast cancer. These therapies can potentially halt the development and spread of cancer, especially if the disease is at an early stage, but all these treatments have various adverse effects on human health. Cancer cells proliferate more rapidly than most normal cells, so chemotherapy is the most suitable treatment. Certain medications can cease dividing cells by destroying the cell's control center region. Other drugs can inhibit the chemical processes essential for cell division. On the contrary, because cancer is frequently identified at a late phase, treating the disease is extraordinarily challenging. Therefore, it is advisable to avoid this fatal condition from occurring. Multiple studies have revealed a continuous inverse connection between cancer and natural materials, such as plant extracts, their fractions, and active principles. These bioactive phytochemicals' have synergistic or cumulative effects in the treatment of cancer disease. This review article examined the effect of various extracts/fractions/active principles obtained from diverse plant origins against breast cancer disease. Information regarding the most commonly used plants, including Alpina galaga, Urtica dioica, Annona muricata, Rosmarinus officinalis, Ficus carica, Nigella sativa, Murraya koenigii, and Urtica dioica have been presented in this study. Owing to the information in this study, these plants exhibited anticancer activities in preclinical MCF-7 carcinoma models by decreasing cell proliferation, inducing programmed cell death, and triggering cell-cycle arrest. The information generated from this review will significantly contribute to developing knowledge of the scientific and medical communities in developing innovative breast cancer treatments.

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Section: Figure 1 Common Causes Of Breast Cancer 2 Classification Of ...mentioning

confidence: 99%

The use of medicinal plants for combating breast cancer: A comprehensive review

Alsubhi

2023

J Exp Bio & Ag Sci

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“…Because natural compounds may affect apoptotic pathways that are typically inhibited in human malignancies, they may provide new opportunities for cancer therapy development. Natural compounds have garnered signi cant interest since they safely and e caciously overcome tumor cells' apoptosis resistance, given the success rate and issues of currently available synthetic medicines for PC [32].…”

Section: Introductionmentioning

confidence: 99%

Medicago sativa Extracts Enhance the Anticancer Efficacy of GEM in PANC-1 Cells through Apoptosis Induction and BAX/BCL-2/CASP3 Expression Modulation

Jamshidi,

Zaman

et al. 2024

Preprint

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Introduction Pancreatic cancer (PC) has a poor prognosis and limited response to therapies. Combinatorial approaches, such as natural product-based therapies, can enhance anticancer efficacy while minimizing side effects. This study evaluated M. sativa’s anticancer properties and its potential as adjunctive therapy with GEM to sensitize PANC-1 cells to chemotherapy. Methods The antioxidant activity (AA) and total phenolic content (TPC) of M. sativa extracts (MeOH, EtOAc, and water) were assessed using the DPPH radical scavenging assay. Cytotoxic effects on PANC1 and HUVEC cells were also evaluated by utilizing the MTT assay. Then, apoptosis detection was performed by Annexin V/PI-flow cytometry (FC). Besides, the DNA fragmentation analysis was conducted utilizing agarose gel electrophoresis (AGE). BCL-2, BAX, and CASP3 expression levels in PANC-1 cells using western blot analysis and qRT-PCR. Results Herein, DPPH IC50 values for M. sativa extracts (water, MeOH, EtOH) were 76.21, 110.32, and 65.39 µg/ml, respectively. The water extract of M. sativa exhibited the highest TPC (4612.15 ± 119.4 mgGAE/g). The cytotoxicity IC50 values for EtOH M. sativa extract, GEM, and combined GEM with EtOH M. sativa on PANC1 cells were 68.74, 43.53, and 41.22 µg/ml M. sativa + 25 µg/ml GEM, respectively, with no toxicity observed in HUVEC cells. FC analysis revealed that Combining GEM and EtOH M. sativa yielded the highest apoptosis rate (25.6%). Expression changes in BCL-2, BAX, and CASP3, as well as morphological alterations and DNA fragmentation, indicated apoptotic cell death. Conclusion Our findings suggested that combining M.sativa EtOH extracts with GEM may represent a promising strategy for treating PC.

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“…On the other hand, other compounds including alkaloids are rarely existed and more specific to some plant genera and species ( Yang and Stöckigt, 2010 ; Choi et al., 2022 ; Zhao et al., 2022 ). Alkaloids are the important part of the defense mechanisms in various plant species and are getting attention worldwide due to their potential to be used in cancer treatment and other therapeutic purposes ( Srivastava and Tiwari, 2022 ). These low molecular weight organic compounds contain alkyl substituted peptide rings; therefore, they can form chemical interactions with many other molecules.…”

Section: Introductionmentioning

confidence: 99%

Production of secondary metabolites using tissue culture-based biotechnological applications

et al. 2023

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Plants are the sources of many bioactive secondary metabolites which are present in plant organs including leaves, stems, roots, and flowers. Although they provide advantages to the plants in many cases, they are not necessary for metabolisms related to growth, development, and reproduction. They are specific to plant species and are precursor substances, which can be modified for generations of various compounds in different plant species. Secondary metabolites are used in many industries, including dye, food processing and cosmetic industries, and in agricultural control as well as being used as pharmaceutical raw materials by humans. For this reason, the demand is high; therefore, they are needed to be obtained in large volumes and the large productions can be achieved using biotechnological methods in addition to production, being done with classical methods. For this, plant biotechnology can be put in action through using different methods. The most important of these methods include tissue culture and gene transfer. The genetically modified plants are agriculturally more productive and are commercially more effective and are valuable tools for industrial and medical purposes as well as being the sources of many secondary metabolites of therapeutic importance. With plant tissue culture applications, which are also the first step in obtaining transgenic plants with having desirable characteristics, it is possible to produce specific secondary metabolites in large-scale through using whole plants or using specific tissues of these plants in laboratory conditions. Currently, many studies are going on this subject, and some of them receiving attention are found to be taken place in plant biotechnology and having promising applications. In this work, particularly benefits of secondary metabolites, and their productions through tissue culture-based biotechnological applications are discussed using literature with presence of current studies.

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Medicinal Plant Used Against Cancer: A Review

Cited by 6 publications

References 44 publications

The use of medicinal plants for combating breast cancer: A comprehensive review

The use of medicinal plants for combating breast cancer: A comprehensive review

Medicago sativa Extracts Enhance the Anticancer Efficacy of GEM in PANC-1 Cells through Apoptosis Induction and BAX/BCL-2/CASP3 Expression Modulation

Production of secondary metabolites using tissue culture-based biotechnological applications

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